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Behavioural Intervention

Transcranial Magnetic Stimulation for Mild Cognitive Impairment (TAMCI Trial)

N/A
Recruiting
Led By Prasad R. Padala, MBBS
Research Sponsored by VA Office of Research and Development
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Be older than 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up through study completion, an average of 1 year

Summary

This trial will study whether or not magnetic stimulation can help treat apathy in older Veterans with memory problems.

Who is the study for?
This trial is for older Veterans with mild memory problems who show signs of apathy. They must meet specific criteria for Mild Cognitive Impairment, have a caregiver, score at least 23 on the MMSE (a test of mental function), and if taking antidepressants, be on a stable dose for one month.
What is being tested?
The study tests whether Transcranial Magnetic Stimulation (TMS) can improve motivation, memory, and functioning in participants. It involves real or sham TMS over 20 sessions targeting the brain's frontal area. The study also examines genetic factors that may influence response to treatment.
What are the potential side effects?
While not explicitly stated here, common side effects of TMS may include headache, scalp discomfort at the site of stimulation, tingling or spasms in facial muscles.

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~through study completion, an average of 1 year
This trial's timeline: 3 weeks for screening, Varies for treatment, and through study completion, an average of 1 year for reporting.

Treatment Details

Study Objectives

Study objectives can provide a clearer picture of what you can expect from a treatment.
Primary study objectives
Change in Apathy Evaluation Scale Score
Secondary study objectives
Change in Conner's Continuous Performance Test Commission Error percentage
Change in Modified Mini Mental State Examination Score
Other study objectives
Functional Activities Questionnaire
Neuropsychiatric Inventory - Questionnaire
T-MoCA
+1 more

Trial Design

3Treatment groups
Active Control
Placebo Group
Group I: Apathy +, rTMS -Active Control1 Intervention
This arm will be followed without intervention
Group II: rTMSActive Control1 Intervention
This group will be randomized to receive rTMS treatment
Group III: ShamPlacebo Group1 Intervention
This group will be randomized to receive sham treatment

Find a Location

Who is running the clinical trial?

University of ArkansasOTHER
494 Previous Clinical Trials
150,205 Total Patients Enrolled
VA Office of Research and DevelopmentLead Sponsor
1,663 Previous Clinical Trials
3,765,650 Total Patients Enrolled
Central Arkansas Veterans Healthcare SystemFED
23 Previous Clinical Trials
342,777 Total Patients Enrolled

Media Library

Transcranial Magnetic Stimulation (Behavioural Intervention) Clinical Trial Eligibility Overview. Trial Name: NCT03590327 — N/A
Neuropsychiatric Symptoms Research Study Groups: Apathy +, rTMS -, rTMS, Sham
Neuropsychiatric Symptoms Clinical Trial 2023: Transcranial Magnetic Stimulation Highlights & Side Effects. Trial Name: NCT03590327 — N/A
Transcranial Magnetic Stimulation (Behavioural Intervention) 2023 Treatment Timeline for Medical Study. Trial Name: NCT03590327 — N/A
~18 spots leftby Nov 2025
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