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Behavioural Intervention

Exercise and Cognitive Training for Mild Cognitive Impairment

N/A

Recruiting

Research Sponsored by University of Maryland, Baltimore

Eligibility Criteria Checklist

Specific guidelines that determine who can or cannot participate in a clinical trial

Must have

Be older than 18 years old

Timeline

Screening 3 weeks

Treatment Varies

Follow Up at baseline and within one week after the corresponding training program.

Awards & highlights

No Placebo-Only Group

Summary

This trial explores if combining brain & exercise training can improve brain health & cognition, in those with mild impairment & healthy seniors. Goal: find ways to prevent or treat dementia by 2025. #alzheimers

Who is the study for?

This trial is for adults aged 50-80 with mild cognitive impairment (MCI), who are sedentary, fluent in English, and can use an iPad or computer. They must be able to live independently despite cognitive deficits. Those with a BMI over 40, severe medical conditions, or inability to undergo MRI due to metal implants or claustrophobia cannot participate.

What is being tested?

The study tests if brain function improves after a combined 12-week program of brain training and aerobic exercise in people with MCI. It explores potential treatments for dementia by assessing changes in the brain and cognition through this dual intervention approach.

What are the potential side effects?

Potential side effects from participating may include typical exercise-related risks such as muscle soreness or strain. Cognitive training is generally low-risk but could potentially cause some frustration or mental fatigue.

Timeline

Screening ~ 3 weeks3 visits

Treatment ~ Varies

Follow Up ~ at baseline and within one week after the corresponding training program.

Screening ~ 3 weeks

Treatment ~ Varies

Follow Up ~at baseline and within one week after the corresponding training program.

This trial's timeline: 3 weeks for screening, Varies for treatment, and at baseline and within one week after the corresponding training program. for reporting.

Treatment Details

Study Objectives

Study objectives can provide a clearer picture of what you can expect from a treatment.

Primary study objectives

Changes in Blood Bioenergetic Markers

Changes in Brain Activation on functional MRI

Changes in Brain blood flow from Arterial spin labeling magnetic resonance imaging (ASL-MRI) in milliliters/100 g/minutes

+5 more

Secondary study objectives

VO2peak

Awards & Highlights

No Placebo-Only Group

All patients enrolled in this study will receive some form of active treatment.

Trial Design

3Treatment groups

Experimental Treatment

Group I: Combined Cognitive and Aerobic ExerciseExperimental Treatment1 Intervention

Combined progressive aerobic exercise 3x/week for 12 weeks and adaptive cognitive training on Cogmed 5x/week for a total of 25 sessions in 5-8 weeks simultaneously.

Group II: Cognitive TrainingExperimental Treatment1 Intervention

Adaptive cognitive training on Cogmed 5x/week for a total of 25 sessions in 5-8 weeks.

Group III: Aerobic ExerciseExperimental Treatment1 Intervention

Progressive aerobic exercise 3x/week for 12 weeks.

Treatment

First Studied

Drug Approval Stage

How many patients have taken this drug

Combined

2023

Completed Phase 3

~1130