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Cognitive Intervention with Leisure Activities for Cognitive Impairment

N/A

Waitlist Available

Led By Sylvie Belleville, PhD

Research Sponsored by Centre de Recherche de l'Institut Universitaire de Geriatrie de Montreal

Eligibility Criteria Checklist

Specific guidelines that determine who can or cannot participate in a clinical trial

Must have

Have a Montreal Cognitive Assessment (MoCA) total score of 20 and above

Be older than 18 years old

Must not have

Presence of disease or injury of the central nervous system

Symptomatic stroke within the previous year

Timeline

Screening 3 weeks

Treatment Varies

Follow Up pre (within 12 weeks before intervention starts) + post-1 (within 8 weeks after the end of intervention) + post-2 (2 years from pre, +/- 3 months)

Awards & highlights

No Placebo-Only Group

Summary

This trial will test a cognitive intervention meant to increase cognitive and brain reserve in people with subjective cognitive decline.

Who is the study for?

This trial is for individuals with subjective cognitive decline who are worried about their memory, have certain scores on memory and cognition tests, can commit to the full intervention plus follow-ups, and have internet at home. Excluded are those with recent major surgery or serious illness, substance abuse issues, no study partner, insufficient English/French proficiency in Toronto/Montreal respectively, or extensive music training.

What is being tested?

The trial is testing a program that combines cognitive training sessions with engaging leisure activities like Spanish lessons or music appreciation (ENGAGE SPANISH/MUSIC) versus discovery-based learning (ENGAGE DISCOVERY). It's designed to see if these activities can boost brain function in people noticing early memory problems.

What are the potential side effects?

Since this trial involves non-medical interventions such as cognitive exercises and leisure activities rather than drugs or medical procedures, traditional side effects are not expected. However, participants may experience fatigue or frustration.

Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below

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My cognitive function score is 20 or higher.

Exclusion Criteria

You may be eligible for the trial if you check “No” for criteria below:

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I have a disease or injury affecting my brain or spinal cord.

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I have had a stroke that caused symptoms in the past year.

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I have had surgery on my brain.

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I have not had major surgery in the last 2 months.

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I have a serious health condition that could lead to death within a year.

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I have been diagnosed with major depression or anxiety.

Timeline

Screening ~ 3 weeks3 visits

Treatment ~ Varies

Follow Up ~ pre (within 12 weeks before intervention starts) + post-1 (within 8 weeks after the end of intervention) + post-2 (2 years from pre, +/- 3 months)

Screening ~ 3 weeks

Treatment ~ Varies

Follow Up ~pre (within 12 weeks before intervention starts) + post-1 (within 8 weeks after the end of intervention) + post-2 (2 years from pre, +/- 3 months)

This trial's timeline: 3 weeks for screening, Varies for treatment, and pre (within 12 weeks before intervention starts) + post-1 (within 8 weeks after the end of intervention) + post-2 (2 years from pre, +/- 3 months) for reporting.

Treatment Details

Study Objectives

Study objectives can provide a clearer picture of what you can expect from a treatment.

Primary study objectives

Changes in episodic memory (composite score)

Secondary study objectives

Changes in attention control (composite score)

Changes in brain function: Brain activation (for a subgroup of participants)

Changes in brain structure: Cortical Thickness (for a subgroup of participants)

+5 more

Other study objectives

Transfer to everyday life (performance-based): Instrumental Activities of Daily Living

Transfer to everyday life (performance-based): Memory Strategies

Transfer to everyday life (self-reported): Activities of daily living

+4 more

Awards & Highlights

No Placebo-Only Group

All patients enrolled in this study will receive some form of active treatment.

Trial Design

2Treatment groups

Experimental Treatment

Active Control

Group I: ENGAGE SPANISH/MUSICExperimental Treatment1 Intervention

Cognitive strategies to improve attention and memory skills and application in selected leisure activities (music or Spanish lessons, and videogames) over 4 months.

Group II: ENGAGE DISCOVERYActive Control1 Intervention

Educational program about brain and healthy aging complemented by learning of new information with videogames, documentaries and group discussions over 4 months.

0 / 7Eligibility criteria met