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Procedure

Ventral Capsulotomy for Obsessive-Compulsive Disorder

Providence, RI
Phase 3
Waitlist Available
Research Sponsored by Butler Hospital
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
* Patients who will be undergoing capsulotomy for severe OCD, as approved by the Butler Hospital Psychiatric Neurosurgery Committe
Be older than 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up 24 months
Awards & highlights
No Placebo-Only Group
Pivotal Trial

Summary

This trial will study a neurosurgery procedure to treat OCD patients who have not improved with conventional therapies. It will examine effects on brain pathways and cognitive tasks to assess its efficacy.

See full description
Who is the study for?
This trial is for a small group of patients with severe Obsessive-Compulsive Disorder (OCD) who haven't improved after trying all other treatments. They must be approved by the Butler Hospital Psychiatric Neurosurgery Committee to undergo capsulotomy, a neurosurgical procedure.Check my eligibility
What is being tested?
The study tests how making lesions in a specific brain area (anterior limb of the internal capsule) affects OCD symptoms. It uses imaging techniques and cognitive tasks to assess changes in brain structure and function after surgery.
What are the potential side effects?
While not explicitly listed, potential side effects may include changes in mood or behavior, headaches, seizures, bleeding or infection from surgery, and possible damage to nearby brain tissue.

Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below
Select...
* Patients who will be undergoing capsulotomy for severe OCD, as approved by the Butler Hospital Psychiatric Neurosurgery Committe

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~24 months
This trial's timeline: 3 weeks for screening, Varies for treatment, and 24 months for reporting.

Treatment Details

Study Objectives

Study objectives can provide a clearer picture of what you can expect from a treatment.
Primary study objectives
Yale-Brown Obsessive-Compulsive Scale (YBOCS)
Secondary study objectives
Hamilton Anxiety Rating Scale (HARS)
Hamilton Depression Rating Scale (HDRS)

Awards & Highlights

No Placebo-Only Group
All patients enrolled in this study will receive some form of active treatment.
Pivotal Trial
The final step before approval, pivotal trials feature drugs that have already shown basic safety & efficacy.

Find a Location

Closest Location:Butler Hospital· Providence, RI· 620 miles

Who is running the clinical trial?

Butler HospitalLead Sponsor
132 Previous Clinical Trials
16,610 Total Patients Enrolled
12 Trials studying Obsessive-Compulsive Disorder
397 Patients Enrolled for Obsessive-Compulsive Disorder
National Institutes of Health (NIH)NIH
2,893 Previous Clinical Trials
8,051,893 Total Patients Enrolled
4 Trials studying Obsessive-Compulsive Disorder
535 Patients Enrolled for Obsessive-Compulsive Disorder

Media Library

Ventral Capsulotomy (Procedure) Clinical Trial Eligibility Overview. Trial Name: NCT05659082 — Phase 3
Obsessive-Compulsive Disorder Research Study Groups:
Obsessive-Compulsive Disorder Clinical Trial 2023: Ventral Capsulotomy Highlights & Side Effects. Trial Name: NCT05659082 — Phase 3
Ventral Capsulotomy (Procedure) 2023 Treatment Timeline for Medical Study. Trial Name: NCT05659082 — Phase 3
~33 spots leftby Dec 2032
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