PC-CT Imaging for Coronary Artery Disease

Recruiting in Palo Alto (17 mi)

+1 other location

Overseen byCynthia McCollough, PhD

Age: 18+

Sex: Any

Travel: May Be Covered

Time Reimbursement: Varies

Trial Phase: Academic

Waitlist Available

Sponsor: Mayo Clinic

No Placebo Group

Trial Summary

What is the purpose of this trial?The purpose of this research trial is to determine whether images taken using a Photon Counting Detector CT scanner (PCD-CT) after the patient has received a drug that makes the heart work harder provide clinically important information about the severity of suspected coronary artery disease compared to CT imaging performed without using the drug that causes the heart to work harder.

Eligibility Criteria

This trial is for patients who need a coronary artery cardiac CT scan and can consent to the study. They should not be pregnant, have severe kidney issues (eGFR ≤ 30), or known allergies to certain heart stress test drugs. It's not for hospitalized patients, those with serious heart rhythm problems, recent seizures, severe asthma/COPD, or a bad reaction to contrast dye before.

Inclusion Criteria

I am willing and able to sign the informed consent.

I am referred for a heart scan using CT, MRI, or nuclear medicine.

I am not pregnant or have a negative pregnancy test result.

Exclusion Criteria

You are allergic to Regadenoson, Adenosine, or Dipyridamole.

I haven't eaten or drunk anything for 3 hours before the cardiac stress test.

Pregnancy

+12 more

Participant Groups

The trial tests if using Photon Counting Detector CT (PCD-CT) scans after administering a drug that stresses the heart provides better information about suspected coronary artery disease severity compared to regular CT scans without the stress-inducing drug.

2Treatment groups

Experimental Treatment

Group I: Clinical Nuclear Medicine or MRI Cardiac Stress Test CohortExperimental Treatment1 Intervention

Subjects scheduled for a clinically indicated nuclear medicine or MRI cardiac stress test will receive a research contrast-enhanced coronary CT angiogram using photon-counting CT at rest and after administration of a cardiac stress agent

Group II: Clinical Coronary CTA CohortExperimental Treatment1 Intervention

Subjects scheduled for a clinically indicated coronary CTA will receive a research contrast-enhanced coronary CT angiogram using photon-counting CT