Beet Juice Supplementation for Coronary Artery Disease
Recruiting in Palo Alto (17 mi)
Age: 18+
Sex: Any
Travel: May Be Covered
Time Reimbursement: Varies
Trial Phase: Academic
Recruiting
Sponsor: University of Florida
Must not be taking: Hormone therapy
Disqualifiers: Stroke, Hypertension, Tobacco, others
Trial Summary
What is the purpose of this trial?Older adults with coronary artery disease (CAD) have impaired vascular and inspiratory muscle function. The objective of this study is to examine the effect of beet juice supplementation on vascular and inspiratory muscle function in older adults with CAD.
Do I need to stop taking my current medications for the trial?
The trial protocol does not specify whether you need to stop taking your current medications. However, it does require that participants have stable coronary artery disease on optimal medical therapy, which suggests you may need to continue your current treatment.
What data supports the effectiveness of this treatment for coronary artery disease?
Research shows that beetroot juice, which is high in nitrates, can improve cardiovascular function by increasing nitric oxide levels in the body. This has been linked to better exercise performance and lower blood pressure, which may benefit people with coronary artery disease.
12345Is beet juice supplementation safe for humans?
Research shows that beet juice supplementation, which is rich in nitrates, is generally safe for humans. It has been used in studies with older adults and patients with COPD (a lung condition) without significant safety concerns, and it can help lower blood pressure and improve exercise performance.
12678How does beetroot juice supplementation differ from other treatments for coronary artery disease?
Beetroot juice supplementation is unique because it is rich in nitrates, which the body converts into nitric oxide, a molecule that helps improve blood flow and reduce blood pressure. This natural approach differs from standard medications by using dietary means to enhance cardiovascular health.
12579Eligibility Criteria
This trial is for adults aged 60-85 with stable coronary artery disease (CAD), confirmed by an angiogram or history of heart issues, who are on optimal medical therapy. Participants must be non-smokers, not engaged in regular aerobic exercise, and women should be postmenopausal. Those with recent heart attacks, strokes, severe lung disease, uncontrolled high blood pressure or certain infections like hepatitis B/C and HIV cannot join.Inclusion Criteria
You have a history of heart disease based on a test showing more than half narrowing in a major heart blood vessel, a previous heart attack, or a past heart surgery to improve blood flow.
You have stable coronary artery disease and are taking the right medications for it.
You are between 60 and 85 years old.
+2 more
Exclusion Criteria
Your heart's pumping ability is lower than 50%.
You have unstable chest pain.
You had a heart attack in the last 6 months.
+12 more
Trial Timeline
Screening
Participants are screened for eligibility to participate in the trial
2-4 weeks
Treatment
Participants receive beet juice supplementation to assess its effect on vascular and inspiratory muscle function
2 weeks
Follow-up
Participants are monitored for safety and effectiveness after treatment
4 weeks
Participant Groups
The study investigates the effects of beet juice supplementation on blood vessel and breathing muscle function in older adults with CAD. It compares two types of beetroot juice: one rich in nitrates and one depleted of nitrates to see which might improve these functions better.
2Treatment groups
Active Control
Placebo Group
Group I: Nitrate rich beetroot juiceActive Control1 Intervention
Group II: Nitrate depleted beetroot juicePlacebo Group1 Intervention
Find a Clinic Near You
Research Locations NearbySelect from list below to view details:
Integrative Cardiovascular Physiology Laboratory, University of FloridaGainesville, FL
Loading ...
Who Is Running the Clinical Trial?
University of FloridaLead Sponsor
References
Dietary nitrate supplementation improves exercise performance and decreases blood pressure in COPD patients. [2018]Dietary nitrate (NO3(-)) supplementation via beetroot juice has been shown to increase the exercise capacity of younger and older adults. The purpose of this study was to investigate the effects of acute NO3(-) ingestion on the submaximal constant work rate exercise capacity of COPD patients. Fifteen patients were assigned in a randomized, single-blind, crossover design to receive one of two treatments (beetroot juice then placebo or placebo then beetroot juice). Submaximal constant work rate exercise time at 75% of the patient's maximal work capacity was the primary outcome. Secondary outcomes included plasma NO3(-) and nitrite (NO2(-)) levels, blood pressure, heart rate, oxygen consumption (VO2), dynamic hyperinflation, dyspnea and leg discomfort. Relative to placebo, beetroot ingestion increased plasma NO3(-) by 938% and NO2(-) by 379%. Median (+interquartile range) exercise time was significantly longer (p = 0.031) following the ingestion of beetroot versus placebo (375.0 + 257.0 vs. 346.2 + 148.0 s, respectively). Compared with placebo, beetroot ingestion significantly reduced iso-time (p = 0.001) and end exercise (p = 0.008) diastolic blood pressures by 6.4 and 5.6 mmHg, respectively. Resting systolic blood pressure was significantly reduced (p = 0.019) by 8.2 mmHg for the beetroot versus the placebo trial. No other variables were significantly different between the beetroot and placebo trials. These results indicate that acute dietary NO3(-) supplementation can elevate plasma NO3(-) and NO2(-) concentrations, improve exercise performance, and reduce blood pressure in COPD patients.
Pharmacokinetics of Nitrate and Nitrite Following Beetroot Juice Drink Consumption. [2021]Label="BACKGROUND" NlmCategory="BACKGROUND">Nitrate (NO3 -)-rich beetroot (BR) juice supplementation has been shown to improve cardiovascular function via reduction to nitrite (NO2 -) and then to the bioactive molecule nitric oxide (NO). However, limited research exists for the role of inorganic NO2 - that is contained naturally within BR.
Cardiorespiratory function associated with dietary nitrate supplementation. [2021]The advent of medical nutrition therapy and nutritional physiology affords the opportunity to link diet to specific cardiovascular mechanisms, suggesting novel treatments for cardiovascular disease. This study tests the hypothesis that beetroot juice increases the plasma nitric oxide (NO) concentration, which is associated with improvements in cardiorespiratory function at rest and during submaximal aerobic exercise. The subjects were 12 healthy, young adult, normotensive African-American females, with a body mass of 61 ± 2 kg, body fat of 28% ± 4%, and peak oxygen consumption of 26 ± 3 mL·kg(-1)·min(-1). The subjects were studied at rest and during cycle ergometer exercise at 40%, 60%, and 80% of peak oxygen consumption. Plasma NO concentration, respiratory quotient (RQ), minute ventilation, systolic and diastolic blood pressure (SBP and DBP), heart rate, and oxygen consumption were compared between isocaloric, isovolumetric placebo control orange juice and experimental beetroot juice treatments on separate days. The beetroot juice treatment increased plasma NO concentration and decreased oxygen consumption, SBP, and the heart rate-SBP product at rest and at 40%, 60%, and 80% of peak oxygen consumption in the absence of significant effects on RQ, minute ventilation, heart rate, and DBP. These findings suggest that, in healthy subjects, beetroot juice treatments increase plasma NO concentration and decrease cardiac afterload and myocardial oxygen demand at rest and during 3 submaximal levels of aerobic exercise. Future studies should determine the cellular and molecular mechanisms responsible for the improvement in cardiorespiratory function associated with dietary nitrate supplementation and whether they translate into better cardiovascular function and exercise tolerance in individuals with a compromised cardiovascular system.
Effect of betaine supplementation on plasma nitrate/nitrite in exercise-trained men. [2021]Betaine, beetroot juice, and supplemental nitrate have recently been reported to improve certain aspects of exercise performance, which may be mechanistically linked to increased nitric oxide. The purpose of the present study was to investigate the effect of betaine supplementation on plasma nitrate/nitrite, a surrogate marker or nitric oxide, in exercise-trained men.
Effect of Vitamin C and Protein Supplementation on Plasma Nitrate and Nitrite Response following Consumption of Beetroot Juice. [2023]Beetroot juice is a food high in nitrate and is associated with cardiometabolic health benefits and enhanced exercise performance through the production of nitric oxide in the nitrate−nitrite−nitric oxide pathway. Since various food components influence this pathway, the aim of this trial was to study the effect of beetroot juice alone and in conjunction with vitamin C or protein on the acute response to plasma nitrate and nitrite levels in healthy middle- to older-aged adults. In this cross-over trial, each participant received, in a randomized order, a single dose of Beet It Sport® alone; Beet It Sport®, plus a 200 mg vitamin C supplement; and Beet It Sport® plus 15 g of whey protein. Plasma levels of nitrate and nitrite were determined prior to and at 1 and 3 h after intervention. Log plasma nitrate and nitrite was calculated to obtain data that were normally distributed, and these data were analyzed using two-way within-factors ANOVA, with time and treatment as the independent factors. There were no statistically significant differences for log plasma nitrate (p = 0.308) or log plasma nitrite (p = 0.391) values across treatments. Log plasma nitrate increased significantly from pre-consumption levels after 1 h (p
Effects of short-term dietary nitrate supplementation on blood pressure, O2 uptake kinetics, and muscle and cognitive function in older adults. [2022]Dietary nitrate (NO(3)(-)) supplementation has been shown to reduce resting blood pressure and alter the physiological response to exercise in young adults. We investigated whether these effects might also be evident in older adults. In a double-blind, randomized, crossover study, 12 healthy, older (60-70 yr) adults supplemented their diet for 3 days with either nitrate-rich concentrated beetroot juice (BR; 2 × 70 ml/day, ∼9.6 mmol/day NO(3)(-)) or a nitrate-depleted beetroot juice placebo (PL; 2 × 70 ml/day, ∼0.01 mmol/day NO(3)(-)). Before and after the intervention periods, resting blood pressure and plasma [nitrite] were measured, and subjects completed a battery of physiological and cognitive tests. Nitrate supplementation significantly increased plasma [nitrite] and reduced resting systolic (BR: 115 ± 9 vs. PL: 120 ± 6 mmHg; P
Efficacy and Variability in Plasma Nitrite Levels during Long-Term Supplementation with Nitrate Containing Beetroot Juice. [2023]Long-term consumption of beetroot juice on efficacy of converting dietary nitrate to plasma nitrate and nitrite was investigated. Adults were randomized to consume either beetroot juice with 380 mg of nitrate (BR) or a beetroot juice placebo (PL) for 12-weeks. Plasma nitrate and nitrite were measured before and 90-minutes after consuming their intervention beverage. Percent change in nitrite across the 90 min was greater in BR (273.2 ± 39.9%) vs. PL (4.9 ± 36.9%). Long-term consumption of nitrate containing beetroot juice increased fasting nitrate and nitrite plasma levels compared to baseline.
Effects of chronic dietary nitrate supplementation on the hemodynamic response to dynamic exercise. [2020]While acute treatment with beetroot juice (BRJ) containing nitrate (NO3 (-)) can lower systolic blood pressure (SBP), afterload, and myocardial O2 demand during submaximal exercise, effects of chronic supplementation with BRJ (containing a relatively low dose of NO3 (-), 400 mg) on cardiac output (CO), SBP, total peripheral resistance (TPR), and the work of the heart in response to dynamic exercise are not known. Thus, in 14 healthy males (22 ± 1 yr), we compared effects of 15 days of both BRJ and nitrate-depleted beetroot juice (NDBRJ) supplementation on plasma concentrations of NOx (NO3 (-)/NO2 (-)), SBP, diastolic blood pressure (DBP), mean arterial pressure (MAP), CO, TPR, and rate pressure product (RPP) at rest and during progressive cycling exercise. Endothelial function was also assessed via flow-mediated dilation (FMD). BRJ supplementation increased plasma NOx from 83.8 ± 13.8 to 167.6 ± 13.2 μM. Compared with NDBRJ, BRJ reduced SBP, DBP, MAP, and TPR at rest and during exercise (P
Dietary beetroot juice - effects on physical performance in COPD patients: a randomized controlled crossover trial. [2018]Label="BACKGROUND AND OBJECTIVE" NlmCategory="OBJECTIVE">Dietary beetroot juice (BR) supplementation has been shown to reduce the oxygen (O2) consumption of standardized exercise and reduce resting blood pressure (BP) in healthy individuals. However, the physiological response of BR in chronic obstructive pulmonary disease (COPD) remains controversial. The objective was to test exercise performance in COPD, supplementing with higher doses of BR for a longer duration compared to previous trials in this patient group.