Antidepressants for Gum Disease in Patients With Depression

Recruiting in Palo Alto (17 mi)

Age: 18+

Sex: Any

Travel: May Be Covered

Time Reimbursement: Varies

Trial Phase: Academic

Waitlist Available

Sponsor: University of Alabama at Birmingham

No Placebo Group

Trial Summary

What is the purpose of this trial?

This trial is testing if antidepressants can help reduce gum inflammation in people with both gum disease and depression. Researchers will collect various samples to study the connection between oral and body inflammation. The goal is to see if treating depression can also improve gum health.

Eligibility Criteria

This trial is for adults who are patients at the UAB Dental School with moderate to severe gum disease, as defined by specific dental measurements. It's open to those on antidepressants and those not suffering from depression but excludes non-English speakers, smokers, immunocompromised individuals, and anyone taking certain anti-inflammatory drugs or medications that could affect gum health.

Inclusion Criteria

I am 18 years old or older.

I am on depression medication and have long-term gum disease.

Able to read and understand informed consent document

Exclusion Criteria

I do not speak English.

You smoke or use tobacco products regularly, at least 10 cigarettes per day.

I need immediate dental care for a condition.

Participant Groups

The study is testing if antidepressants can lessen gum inflammation in people with periodontal disease. Participants will undergo standard periodontal surgery while their inflammatory markers are monitored to see if there's a difference between those with and without depression.

Group I: Chronic Periodontitis and Depression Medications Active Control 1 Intervention

Patients with clinically diagnosed depression taking (SSRIs, NDRIs, SNRIs, tricyclic antidepressants) and with chronic periodontitis

Group II: Chronic Periodontitis Active Control 1 Intervention

Patients without depression, not taking any antidepressants and with chronic periodontitis

Group III: Chronic Periodontitis without Depression Medications Active Control 1 Intervention

Patients with clinically diagnosed depression not taking any antidepressants (SSRIs NDRIs, SNRIs and Tricyclic antidepressants) and with chronic periodontitis

Find a Clinic Near You

Research Locations Nearby Select from list below to view details:

Unversity of Alabama at Birmingham, School of Dentistry Birmingham, AL

Who Is Running the Clinical Trial?

University of Alabama at Birmingham Lead Sponsor

References