Interpersonal Psychotherapy for Depression
Recruiting in Palo Alto (17 mi)
Age: Any Age
Sex: Any
Travel: May Be Covered
Time Reimbursement: Varies
Trial Phase: Academic
Recruiting
Sponsor: Children's National Research Institute
Disqualifiers: Bipolar, Schizophrenia, Substance abuse, others
No Placebo Group
Approved in 2 Jurisdictions
Trial Summary
What is the purpose of this trial?The goal of this clinical trial is to test the effectiveness and implementation of delivering Enhanced Brief Interpersonal Psychotherapy (IPT-B), an evidence-based maternal depression treatment, to mothers of children aged 4-11 years in an urban pediatric asthma clinic. Researchers will compare Enhanced IPT-B and supplemented usual care (brief care coordination). The main questions the trial aims to answer are:
1. Does Enhanced IPT-B decrease maternal depressive symptoms?
2. Does Enhanced IPT-B improve child asthma management and health outcomes (exacerbations, symptoms, control)?
3. What are the preliminary implementation outcomes of delivering Enhanced IPT-B in an urban pediatric asthma clinic?
Do I have to stop taking my current medications for this trial?
The trial information does not specify whether you need to stop taking your current medications. It is best to discuss this with the trial coordinators.
What data supports the effectiveness of the treatment Enhanced Brief Interpersonal Psychotherapy for Depression?
Research shows that Brief Interpersonal Psychotherapy (IPT-B), a shorter version of Interpersonal Psychotherapy (IPT), is effective for treating depression, offering quick relief and using fewer resources. Studies, including randomized controlled trials, support its benefits, making it a practical option for those unable to attend longer therapy sessions.
12345Is Interpersonal Psychotherapy (IPT) safe for humans?
Interpersonal Psychotherapy (IPT) is a well-researched treatment for depression and is generally considered safe for humans, with no specific safety concerns highlighted in the available studies.
13467How is Enhanced Brief Interpersonal Psychotherapy (Enhanced IPT-B) different from other treatments for depression?
Enhanced Brief Interpersonal Psychotherapy (Enhanced IPT-B) is unique because it offers the benefits of traditional Interpersonal Psychotherapy (IPT) in just eight sessions, making it a quicker option for those who may not be able to commit to longer therapy. It focuses on improving interpersonal relationships to alleviate depression, addressing issues like grief, role transitions, and interpersonal conflicts.
34589Eligibility Criteria
This trial is for mothers with depression who have children aged 4-11 years with asthma, treated at an urban pediatric asthma clinic. Participants should not be currently receiving structured psychotherapy and must be able to attend multiple therapy sessions.Inclusion Criteria
Maternal: PHQ-9 ≥ 10 during standardized screening at the child with asthma's clinic visit
Maternal: Black (self-identified)
I am 18 years old or older.
+6 more
Exclusion Criteria
Maternal: Schizophrenia
Maternal: Current substance abuse/dependence
Maternal: Acutely suicidal (high risk on the C-SSRS at child's asthma clinic visit)
+4 more
Trial Timeline
Screening
Participants are screened for eligibility to participate in the trial
2-4 weeks
1 visit (in-person)
Treatment
Mothers receive Enhanced IPT-B, consisting of a pre-treatment session and eight weekly psychotherapy sessions
8-12 weeks
9 visits (in-person)
Follow-up
Participants are monitored for maternal mental health and child asthma management outcomes
6 months
2 visits (in-person) at 3 and 6 months post-baseline
Participant Groups
The study tests Enhanced Brief Interpersonal Psychotherapy (IPT-B) against supplemented usual care in reducing maternal depression and improving child asthma management. It will assess the effectiveness of IPT-B delivered in a real-world clinical setting.
2Treatment groups
Experimental Treatment
Active Control
Group I: Enhanced IPT-BExperimental Treatment1 Intervention
Enhanced Brief Interpersonal Psychotherapy
Group II: Supplemented Usual CareActive Control1 Intervention
Short-term care coordination
Enhanced Brief Interpersonal Psychotherapy is already approved in United States, European Union for the following indications:
🇺🇸 Approved in United States as Interpersonal Psychotherapy for:
- Major Depressive Disorder
- Postpartum Depression
🇪🇺 Approved in European Union as Interpersonal Psychotherapy for:
- Major Depressive Disorder
- Postpartum Depression
Find a Clinic Near You
Research Locations NearbySelect from list below to view details:
Children's National HospitalWashington, United States
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Who Is Running the Clinical Trial?
Children's National Research InstituteLead Sponsor
National Institute on Minority Health and Health Disparities (NIMHD)Collaborator
References
Failures in interpersonal psychotherapy (IPT): factors related to treatment resistances. [2021]Interpersonal psychotherapy (IPT) is an effective treatment for depression across the lifespan and across cultures. However, even when delivered with fidelity, some patients drop out and others do not improve sufficiently. Attention to IPT treatment attrition, dropout, nonresponse, or failure can elucidate its limitations and the opportunities to improve its effectiveness. Studies of factors known to moderate and negatively predict IPT depression treatment response are reviewed along with recommended modifications to improve outcomes. Although the risk of treatment failure always exists, it is possible to enhance treatment effectiveness by attending to the therapeutic alliance, strategically addressing depression, and adapting IPT to patient characteristics. These include adding pharmacotherapy, extending the course of treatment, and targeting specific symptoms or interpersonal vulnerabilities. Case examples illustrate several of these points.
Interpersonal psychotherapy for chronic depression. [2022]Interpersonal psychotherapy (IPT) is a time-limited, manualized, life-event-based treatment of demonstrated efficacy for acute major depression. This article describes its adaptation and application to chronic forms of unipolar depression. The interpersonal difficulties of chronically depressed patients present a potentially good fit for a therapy that builds interpersonal functioning, but the chronicity of illness and paucity of life events of dysthymic patients complicate the use of IPT. Recent outcome research is reviewed. A case example illustrates the clinical approach and potential benefits. Based on a limited number of studies, the benefits of acute IPT for chronic depression appear non-specific and modest.
Implementing interpersonal psychotherapy in a psychiatry residency training program. [2006]Interpersonal psychotherapy (IPT) for depression is a brief, well researched treatment for acute major depression. This article describes the implementation of IPT as an evidence-based treatment for depression in a psychiatry residency program.
Brief Interpersonal Psychotherapy (IPT-B): Overview and Review of Evidence. [2019]Brief Interpersonal Psychotherapy (IPT-B) is an eight-session adaption of Interpersonal Psychotherapy (IPT), an evidence-based psychotherapy for depression. The rationale for developing a briefer form of IPT rests on the paucity of empirical evidence linking increased therapy "dose" to enhanced therapeutic effects. The goal of IPT-B is to allow individuals who are unlikely to attend 16 sessions of psychotherapy-because of external or internal constraints-to receive the full benefits of IPT in fewer sessions. We provide an overview of IPT-B and describe the modifications made to standard IPT to adjust for the truncated time course. We then review the empirical evidence supporting this briefer model of IPT, including four open studies, one matched case-control study, and three randomized controlled trials. We conclude that IPT-B offers the dual advantages of rapid relief from suffering and decreased resource utilization.
Comparative outcomes among the problem areas of interpersonal psychotherapy for depression. [2021]Although interpersonal psychotherapy (IPT) is an efficacious treatment for acute depression, the relative efficacy of treatment in each of the four IPT problem areas (grief, role transitions, role disputes, interpersonal deficits) has received little attention. We evaluated the specificity of IPT by comparing treatment success among patients whose psychotherapy focused on each problem area. Moreover, we sought to understand how the patient characteristics and interpersonal problems most closely linked to the onset of a patient's current depression contributed to IPT success.
Developments in interpersonal psychotherapy. [2017]Interpersonal psychotherapy (IPT), a time-limited psychotherapy, was developed in the 1970s as a treatment for outpatient adults with major depression. It since has grown in its range of research applications and in its clinical accessibility.
National dissemination of interpersonal psychotherapy for depression in veterans: therapist and patient-level outcomes. [2018]To evaluate the effects of training in and delivery of interpersonal psychotherapy (IPT) for depression throughout the U.S. Department of Veterans Affairs health care system on therapists' competency and patients' clinical outcomes.
[Interpersonal psychotherapy (IPT) of depression: an overview of the psychiatric historical background and clinical practice of IPT]. [2006]Among the forms of short-term psychotherapies for the treatment of depression, IPT (16 - 20 sessions) by Klerman u. Mitarb. is meanwhile one of the most well known and clinically practiced approaches. IPT has also been carefully controlled in a variety of studies proving efficacy. Interpersonal psychotherapy is based on the ideas of the interpersonal school of psychiatry. The hypothesis is that psychiatric illnesses and here depression develop in an interpersonal context. Life problems may contribute to onset and potentially chronicity of (current) depression and vice versa. By enhancing interpersonal functioning of the depressed patient IPT initiates the reduction of depressive symptomatology and helps solving of current life problems as dual goal of therapy.
[Current status of interpersonal psychotherapy]. [2019]An overview of the state of the art in Interpersonal Psychotherapy (IPT) of depression is given. Since IPT is a standardized, efficient, and economical therapy form, it is anticipated that IPT will gain increasing importance in Germany in the field of psychiatry/psychotherapy. It can be learned by experienced psychotherapists, regardless of their psychotherapeutic orientation, in a standardized training program in a relatively short time. IPT is a short-term psychotherapy designed specifically for the treatment of depression which was developed by Klerman and Weissman at the end of the sixties. It is based on the observation that depressive disorders usually occur in a psychosocial and interpersonal context. The focus of this psychotherapeutic procedure is therefore on dealing with the patients' psychosocial and interpersonal conflicts. The present article describes the use of IPT as well as its theoretical and empirical background. In addition the educational program in IPT is described and a comparison with other psychotherapies is given. Finally the article summarizes efficacy studies and derivative forms of IPT.