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Molecular Analysis of Eczema and Food Allergy

N/A

Recruiting

Led By Chase Schuler, MD

Research Sponsored by University of Michigan

Eligibility Criteria Checklist

Specific guidelines that determine who can or cannot participate in a clinical trial

Must have

Be younger than 65 years old

Timeline

Screening 3 weeks

Treatment Varies

Follow Up approximately 4 hours (day 1 during the food challenge)

Awards & highlights

No Placebo-Only Group

Summary

"This trial aims to investigate the relationship between atopic dermatitis and food allergy. By collecting blood and skin samples from participants, the study seeks to understand if these conditions have common genetic or biochemical markers that

Who is the study for?

This trial is for people with food allergies to specific items like peanuts or milk, confirmed by an allergist, and those with atopic dermatitis (eczema). It also includes healthy individuals without these conditions. Excluded are those with serious health issues like active cardiovascular disease or cancer, certain medication use that affects test results, other skin conditions besides eczema, recent biologic medication changes, past oral immunotherapy for food allergies, and pregnant women.

What is being tested?

The study aims to find if there's a link between atopic dermatitis (eczema) and food allergy by collecting blood and skin samples from participants. Some may undergo a food challenge where they eat small amounts of the suspected allergen under medical supervision while their biological responses are recorded.

What are the potential side effects?

Potential side effects mainly stem from the Oral Food Challenge which can trigger allergic reactions ranging from mild symptoms like itching or hives to more severe ones such as difficulty breathing or anaphylaxis. Skin biopsies might cause pain, infection risk at the biopsy site.

Timeline

Screening ~ 3 weeks3 visits

Treatment ~ Varies

Follow Up ~ approximately 4 hours (day 1 during the food challenge)

Screening ~ 3 weeks

Treatment ~ Varies

Follow Up ~approximately 4 hours (day 1 during the food challenge)

This trial's timeline: 3 weeks for screening, Varies for treatment, and approximately 4 hours (day 1 during the food challenge) for reporting.

Treatment Details

Study Objectives

Study objectives can provide a clearer picture of what you can expect from a treatment.

Primary study objectives

Anaphylaxis occurrence rates in each group

Secondary study objectives

Anaphylaxis likelihood in each group based on the Brighton score

Anaphylaxis severity in each group

Reaction rates in each group

Awards & Highlights

No Placebo-Only Group

All patients enrolled in this study will receive some form of active treatment.