Exercise for Dystonia
Recruiting in Palo Alto (17 mi)
Age: 18+
Sex: Any
Travel: May Be Covered
Time Reimbursement: Varies
Trial Phase: Academic
Recruiting
Sponsor: University of Florida
Must be taking: BoNT injections
Disqualifiers: Significant pain, Cognitive impairment, others
No Placebo Group
Approved in 1 Jurisdiction
Trial Summary
What is the purpose of this trial?The purpose of this research study is to investigate how the brain and motor behavior changes in individuals with dystonia in response to exercise training.
Will I have to stop taking my current medications?
The trial does not specify if you need to stop taking your current medications. However, it mentions that participants should be receiving maximally tolerated doses of BoNT injections and/or oral therapy, suggesting you may continue these treatments.
What data supports the effectiveness of the treatment Progressive Resistance Training (PRT) for dystonia?
Research on Parkinson's disease, a condition with some similarities to dystonia, shows that Progressive Resistance Training (PRT) can help improve strength, balance, and movement. This suggests that PRT might also be beneficial for people with dystonia.
12345Is progressive resistance training safe for humans?
Progressive resistance training (PRT) has been studied in people with Parkinson's disease and cerebral palsy, and it is generally considered safe for these conditions. These studies suggest that PRT can be safely used as part of rehabilitation programs, although specific safety data for dystonia is not provided.
23678How is the treatment Progressive Resistance Exercise unique for dystonia?
Progressive Resistance Exercise (PRT) is unique because it focuses on gradually increasing the resistance or weight used during exercise, which can help improve muscle strength and function. This approach is different from other treatments for dystonia that may not specifically target muscle strength through resistance training.
2391011Eligibility Criteria
This trial is for individuals aged 30-85 with moderate cervical dystonia, confirmed by a specialist. They should be able to exercise but not currently in another structured program or receiving regular therapy. Participants must not have significant pain, arthritis, cognitive impairments, implanted electrical devices, active seizures, and women of childbearing age must pass pregnancy tests.Inclusion Criteria
My condition is considered moderate in severity.
My condition is considered moderate in severity.
I haven't seen much improvement despite taking the highest safe doses of BoNT injections for my neck and/or oral medications.
+6 more
Exclusion Criteria
You have major problems with your thinking and memory.
I am currently in a structured exercise program or receiving therapy.
Pregnancy tests will be carried out for each female subject of child bearing potential prior to the participation in the study and prior to each follow up visit (as indicated)
+5 more
Trial Timeline
Screening
Participants are screened for eligibility to participate in the trial
2-4 weeks
Treatment
Participants in the exercise group perform physical therapist-guided progressive resistance exercises twice a week for 6 months, while the control group continues standard pharmacological therapies.
6 months
Follow-up
Participants are monitored for safety and effectiveness after treatment, with assessments of brain effects using TMS and fMRI.
4 weeks
Participant Groups
The study is examining the effects of progressive resistance exercise compared to standard care on brain and motor behavior changes in people with dystonia. It aims to see if exercise can improve symptoms for those who haven't fully benefited from injections or oral medications.
2Treatment groups
Experimental Treatment
Active Control
Group I: Progressive resistance exercise (exercise group)Experimental Treatment1 Intervention
Subjects will receive physical therapy that will predominantly include progressive resistance exercise training program along with continuation of standard of care (exercise group)
Group II: Standard of care (non-exercise group).Active Control1 Intervention
Subjects will receive continuation of standard of care (non-exercise group).
Find a Clinic Near You
Research Locations NearbySelect from list below to view details:
University of FloridaGainesville, FL
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Who Is Running the Clinical Trial?
University of FloridaLead Sponsor
National Institute of Neurological Disorders and Stroke (NINDS)Collaborator
References
Exercise and Progressive Supranuclear Palsy: the need for explicit exercise reporting. [2020]Progressive Supranuclear Palsy (PSP) is the most frequent form of atypical Parkinsonism. Although there is preliminary evidence for the benefits of gait rehabilitation, balance training and oculomotor exercises in PSP, the quality of reporting of exercise therapies appears mixed. The current investigation aims to evaluate the comprehensiveness of reporting of exercise and physical activity interventions in the PSP literature.
Effectiveness of Progressive Resistance Training in Parkinson's Disease: A Systematic Review and Meta-Analysis. [2023]The aim of this study was to systematically explore progressive resistance training (PRT) effects in Parkinson's disease (PD).
Progressive resistance training in Parkinson's disease: a systematic review and meta-analysis. [2022]To investigate if there is evidence on effectiveness of progressive resistance training in rehabilitation of Parkinson disease.
Autogenic training shows short-term benefits in patients with early Parkinson's disease. [2019]A trial of people with early Parkinson's disease compared 32 having physiotherapy with a similar number who had an additional 15 minutes of autogenic training (AT).
Power vs strength training to improve muscular strength, power, balance and functional movement in individuals diagnosed with Parkinson's disease. [2020]Declines in strength and power are cardinal symptoms of Parkinson's disease (PD), a progressive neuromuscular disorder. Progressive resistance training (PRT) has been shown to reduce a wide variety of PD-related motor deficits; however, no study has examined differences between the two most common RT methodologies utilized in this population, high-load, low velocity strength training (ST) and low-load, high-velocity power training (PT). The primary purpose of this study was to compare the effects of ST and PT on measures of strength, power, balance and functional movement in persons with PD.
What are the optimum training parameters of progressive resistance exercise for changes in muscle function, activity and participation in people with cerebral palsy? A systematic review and meta-regression. [2023]To explore the effect of progressive resistance exercise (PRE) on impairment, activity and participation of people with cerebral palsy (CP). Also, to determine which programme parameters provide the most beneficial effects.
Progressive Resistance Training Improves Bradykinesia, Motor Symptoms and Functional Performance in Patients with Parkinson's Disease. [2022]Bradykinesia and muscle weaknesses are common symptoms of Parkinson's Disease (PD) and are associated with impaired functional performance, increased risk of falls, and reduced quality of life. Recent studies have pointed to progressive resistance training (PRT) as an effective method to control and reduce these symptoms, increasing possibilities to treat the disease. However, few studies have focused on assessing the PRT effects in the short-term. Therefore, the present study aimed to assess the short-term PRT effects on people with PD, in order to offer new parameters for a better understanding of its effects, so as an adequation and PRT use as a complementary therapy.
Neurorehabilitation with versus without resistance training after botulinum toxin treatment in children with cerebral palsy: a randomized pilot study. [2012]To compare the effects of physical rehabilitation with (PRT) and without (CON) progressive resistance training following treatment of spastic plantarflexors with botulinum toxin type A (BoNT) in children with cerebral palsy (CP).
Effects of moderate-volume, high-load lower-body resistance training on strength and function in persons with Parkinson's disease: a pilot study. [2021]Background. Resistance training research has demonstrated positive effects for persons with Parkinson's disease (PD), but the number of acute training variables that can be manipulated makes it difficult to determine the optimal resistance training program. Objective. The purpose of this investigation was to examine the effects of an 8-week resistance training intervention on strength and function in persons with PD. Methods. Eighteen men and women were randomized to training or standard care for the 8-week intervention. The training group performed 3 sets of 5-8 repetitions of the leg press, leg curl, and calf press twice weekly. Tests included leg press strength relative to body mass, timed up-and-go, six-minute walk, and Activities-specific Balance Confidence questionnaire. Results. There was a significant group-by-time effect for maximum leg press strength relative to body mass, with the training group significantly increasing their maximum relative strength (P .05). Conclusions. Moderate volume, high-load weight training is effective for increasing lower-body strength in persons with PD.
Cardiovascular, perceived exertion and affective responses during aerobic exercise performed with imposed and a self-selected intensity in patients with Parkinson's disease. [2021]Exercise with self-selected intensity (SSI) has emerged as a new strategy for exercise prescription aiming to increase exercise adherence in Parkinson's disease (PD).
Periodized Resistance Training With and Without Functional Training Improves Functional Capacity, Balance, and Strength in Parkinson's Disease. [2023]Strand, KL, Cherup, NP, Totillo, MC, Castillo, DC, Gabor, NJ, and Signorile, JF. Periodized resistance training with and without functional training improves functional capacity, balance, and strength in Parkinson's disease. J Strength Cond Res 35(6): 1611-1619, 2021-Periodized progressive resistance training (PRT) is a common method used to improve strength in persons with Parkinson's disease (PD). Many researchers advocate the addition of functional training to optimize translation to activities of daily living; however, machine-based PRT, using both force and velocity training components, may elicit similar benefits. Thirty-five persons with PD (Hoehn and Yahr I-III) were randomized into a strength, power, and hypertrophy (SPH; n = 17) or strength, power, and functional (SP + Func; n = 18) group, training 3 times weekly for 12 weeks. Both groups performed machine-based strength and power training on days 1 and 2 each week, respectively; whereas, on day 3, SPH group performed machine-based hypertrophy training and SP + Func group performed functional training. Functional performance was tested using the timed up and go, 30-second sit-to-stand (30-s STS), gallon-jug shelf-transfer, and seated medicine ball throw (SMBT) tests. Balance (Mini-BESTest), strength, motor symptoms (UPDRS-III), quality of life, and freezing of gait (FOG) were also assessed. Repeated measures analysis of variance revealed a main effect for time (p ≤ 0.05) with significant improvements for the sample in the 30-s STS (p = 0.002), SMBT (p = 0.003), Mini-BESTest (p