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Procedure

TMS Impact on Cognitive Sequencing

N/A

Recruiting

Led By John E Desmond, Ph.D.

Research Sponsored by Johns Hopkins University

Eligibility Criteria Checklist

Specific guidelines that determine who can or cannot participate in a clinical trial

Must have

Age 18-50

Be between 18 and 65 years old

Must not have

Neurological or systemic disorder which can cause dementia or cognitive dysfunction

History of definite stroke

Timeline

Screening 3 weeks

Treatment Varies

Follow Up during scan up to 1 hour

Awards & highlights

No Placebo-Only Group

Summary

This trial aims to explore how the cerebellum contributes to both motor and cognitive functions, by testing how disruption and stimulation of the cerebellum can affect the ability to predict and sequence events.

Who is the study for?

This trial is for individuals aged 18-50 who can consent, have at least an 8-year education, speak English fluently, and are right-handed. It's not for those with recent drug use, cognitive impairments due to neurological disorders, psychiatric disorders including substance abuse, stroke history, MRI contraindications or visual deficits.

What is being tested?

The study tests the effect of cerebellar stimulation on brain activity during tasks that require sequencing and those that don't. Participants will undergo Transcranial Magnetic Stimulation (TMS) while performing these tasks to see how it affects their brain function.

What are the potential side effects?

Potential side effects from TMS may include discomfort at the stimulation site, headache, lightheadedness or seizures in rare cases. Most people tolerate TMS well without serious complications.

Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below

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I am between 18 and 50 years old.

Exclusion Criteria

You may be eligible for the trial if you check “No” for criteria below:

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I have a condition that could lead to memory loss or trouble thinking.

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I have had a stroke before.

Timeline

Screening ~ 3 weeks3 visits

Treatment ~ Varies

Follow Up ~ during scan up to 1 hour

Screening ~ 3 weeks

Treatment ~ Varies

Follow Up ~during scan up to 1 hour

This trial's timeline: 3 weeks for screening, Varies for treatment, and during scan up to 1 hour for reporting.

Treatment Details

Study Objectives

Study objectives can provide a clearer picture of what you can expect from a treatment.

Primary study objectives

functional magnetic resonance imaging brain activation

Secondary study objectives

behavioral reaction time (milliseconds)

percent correct of behavioral responses

Awards & Highlights

No Placebo-Only Group

All patients enrolled in this study will receive some form of active treatment.

Trial Design

2Treatment groups

Experimental Treatment

Active Control

Group I: Cerebellar StimulationExperimental Treatment4 Interventions

TMS will be administered to the cerebellum on half the trials of a sequence-demanding task, and on half the trials of a non-sequence-demanding task. Task order will be counterbalanced.

Group II: Occipital StimulationActive Control4 Interventions

TMS will be administered to an occipital control region on half the trials of a sequence-demanding task, and on half the trials of a non-sequence-demanding task. Task order will be counterbalanced.

0 / 3Eligibility criteria met