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Vitamin
Vitamin C for Musculoskeletal Pain
N/A
Recruiting
Led By Raoul Daoust, MD MSc
Research Sponsored by Hopital du Sacre-Coeur de Montreal
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial Must have
Discharged with an opioid prescription
Be older than 18 years old
Must not have
Active cancer
Treated with cyclosporin or coumadin
Timeline
Screening 3 weeks
Treatment Varies
Follow Up 3 months
Summary
This trial aims to study whether taking vitamin C can reduce the amount of opioid pills needed for pain relief in patients discharged from the emergency department with acute musculoskeletal pain. The study will compare the use
Who is the study for?
This trial is for adults over 18 who visited the emergency department (ED) with musculoskeletal pain that's been there for less than two weeks. They must have left the ED with a prescription for opioids and be able to speak French or English.
What is being tested?
The study tests if taking vitamin C reduces opioid use after an ED visit for acute musculoskeletal pain. Participants will either receive 1000 mg of vitamin C twice daily or a placebo, over two weeks, and track their opioid intake and pain levels.
What are the potential side effects?
Vitamin C is generally considered safe but can sometimes cause digestive issues like heartburn, stomach cramps, nausea, or diarrhea at high doses.
Eligibility Criteria
Inclusion Criteria
You may be eligible if you check “Yes” for the criteria belowSelect...
I was prescribed opioids when I was discharged.
Exclusion Criteria
You may be eligible for the trial if you check “No” for criteria below:Select...
My cancer is currently active.
Select...
I have been treated with cyclosporin or coumadin.
Select...
I am allergic or sensitive to milk or morphine.
Timeline
Screening ~ 3 weeks3 visits
Treatment ~ Varies
Follow Up ~ 3 months
Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~3 months
Treatment Details
Study Objectives
Study objectives can provide a clearer picture of what you can expect from a treatment.Primary study objectives
Contraceptives, Oral
Secondary study objectives
Average pain relief
Limb structure
Incidence of chronic pain (including complex regional pain syndrome (CRPS)) globally and for each type of MSK pain
+4 moreSide effects data
From 2020 Phase 2 trial • 34 Patients • NCT0190515021%
Nausea
14%
Fatigue
14%
Depression
14%
Diarrhea
14%
Pain
14%
Anxiety
7%
Anemia
7%
Ascites
7%
Insomnia
100%
80%
60%
40%
20%
0%
Study treatment Arm
G-FLIP Alone for 4 Weeks, Then G-FLIP+VitaminC. When DP Occurred, Then G-FLIP-DM+VitaminC
G-FLIP+VitaminC. When DP Occurred, Then G-FLIP-DM+Vitamin C.
Trial Design
2Treatment groups
Experimental Treatment
Placebo Group
Group I: Vitamin CExperimental Treatment1 Intervention
1 000 mg vitamin C taken orally twice a day
Group II: PlaceboPlacebo Group1 Intervention
Matching placebo
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
Vitamin C
2017
Completed Phase 4
~18470
Find a Location
Who is running the clinical trial?
Hopital de l'Enfant-JesusOTHER
16 Previous Clinical Trials
5,358 Total Patients Enrolled
1 Trials studying Acute Pain
2,240 Patients Enrolled for Acute Pain
Hopital du Sacre-Coeur de MontrealLead Sponsor
51 Previous Clinical Trials
11,684 Total Patients Enrolled
2 Trials studying Acute Pain
3,001 Patients Enrolled for Acute Pain
Raoul Daoust, MD MScPrincipal InvestigatorUniversité de Montréal
3 Previous Clinical Trials
3,547 Total Patients Enrolled
2 Trials studying Acute Pain
3,001 Patients Enrolled for Acute Pain