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Speech Production Tasks for Understanding Speech Disorders

N/A

Waitlist Available

Led By Lingyun Zhao, PhD

Research Sponsored by University of California, San Francisco

Eligibility Criteria Checklist

Specific guidelines that determine who can or cannot participate in a clinical trial

Must have

Be older than 18 years old

Timeline

Screening 3 weeks

Treatment Varies

Follow Up during inpatient hospitalization, up to 14 days after surgical electrode implantation

Awards & highlights

No Placebo-Only Group

Summary

This trial seeks to understand how the brain controls the stopping of speech production, to help us understand communication disorders like stuttering & aphasia.

Who is the study for?

This trial is for individuals with medication-resistant epilepsy at UCSF who are undergoing surgical electrode implantation to locate their seizure focus. They must be willing and able to cooperate with study tasks involving speech production.

What is being tested?

The study aims to understand how the brain stops ongoing speech, which is crucial for smooth conversations and turn-taking. It will explore neural mechanisms in patients performing speech tasks during electrode monitoring.

What are the potential side effects?

Since this trial involves non-invasive speech production tasks, there are no direct side effects from interventions like drugs or surgery. However, participants may experience fatigue or stress from the tasks.

Timeline

Screening ~ 3 weeks3 visits

Treatment ~ Varies

Follow Up ~ during inpatient hospitalization, up to 14 days after surgical electrode implantation

Screening ~ 3 weeks

Treatment ~ Varies

Follow Up ~during inpatient hospitalization, up to 14 days after surgical electrode implantation

This trial's timeline: 3 weeks for screening, Varies for treatment, and during inpatient hospitalization, up to 14 days after surgical electrode implantation for reporting.

Treatment Details

Study Objectives

Study objectives can provide a clearer picture of what you can expect from a treatment.

Primary study objectives

Mean Change in Neural Activity

Secondary study objectives

Number of sites with stimulation induced speech termination

Awards & Highlights

No Placebo-Only Group

All patients enrolled in this study will receive some form of active treatment.

Trial Design

1Treatment groups

Experimental Treatment

Group I: Voice and Electrocorticography (ECoG) recording during Speech Production TasksExperimental Treatment1 Intervention

Participants produce speech following visual cues on a computer while ECoG signals for neural activity and voice was recorded during their inpatient hospitalization at the University of California, San Francisco (UCSF).

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