Advanced MRI for Brain Tumors

Recruiting in Palo Alto (17 mi)

Overseen by Robert Young, MD

Age: 18+

Sex: Any

Travel: May Be Covered

Time Reimbursement: Varies

Trial Phase: Academic

Recruiting

Sponsor: Memorial Sloan Kettering Cancer Center

Disqualifiers: Claustrophobia, Allergic to Gd-DTPA, Pregnant, others

No Placebo Group

Approved in 1 Jurisdiction

Trial Summary

What is the purpose of this trial?

The researchers think that the use of advanced MR imaging may help people with this disease, because it may better predict areas within a malignant glioma (brain tumor) that are at a high risk of recurring. WeThe reserchers are doing this study to see whether this advanced imaging is a safe treatment that causes few or mild side effects in people with brain tumors.

Will I have to stop taking my current medications?

The trial information does not specify whether you need to stop taking your current medications.

What data supports the effectiveness of the treatment MRI and advanced MRI sequences for brain tumors?

Advanced MRI sequences provide more detailed information about brain tumors, such as their size, shape, and how they affect surrounding brain tissue. This helps doctors better plan surgeries and treatments, potentially improving patient outcomes by reducing surgical risks and accurately assessing the tumor's response to therapy. ^{1 2 3 4 5}

Is advanced MRI safe for use in humans?

The research does not provide specific safety data for advanced MRI, but MRI is a widely used imaging technique in clinical settings, generally considered safe for humans when standard safety guidelines are followed. ^{1 6 7 8 9}

How does advanced MRI differ from other treatments for brain tumors?

Advanced MRI is unique because it uses specialized imaging techniques to provide detailed information about brain tumors, such as their cellular structure, blood supply, and metabolism, which helps in better diagnosis, treatment planning, and monitoring compared to standard MRI. ^{1 2 10 11 12}

Research Team

Robert Young, MD

Principal Investigator

Memorial Sloan Kettering Cancer Center

Eligibility Criteria

This trial is for adults over 18 with suspected or confirmed high or low grade gliomas, which are types of brain tumors. They should be candidates for radiation therapy and able to consent to the study. It's not suitable for those allergic to MRI contrast agents, have contraindications to MRI like pacemakers, are pregnant/nursing, can't undergo an MRI due to extreme claustrophobia, or cannot cooperate during the procedure.

Inclusion Criteria

I am 18 years old or older.

My brain tumor is suspected to be serious or has a specific genetic change.

Patient and/or guardian is able to provide written informed consent prior to study registration

Exclusion Criteria

I am not allergic or have any issues with MRI contrast dye.

I cannot undergo MRI or radiation therapy planning.

Extreme claustrophobia that precludes MRI scan

Trial Timeline

Screening

Participants are screened for eligibility to participate in the trial

2-4 weeks

Preoperative Planning MRI

Advanced MRI studies are obtained at the time of the routinely scheduled preoperative planning MRI

1 week

1 visit (in-person)

Pre-RT Planning MRI

Advanced MRI studies are obtained at the time of the routinely scheduled pre-RT planning MRI approximately 3±2 weeks after surgery

3 weeks

1 visit (in-person)

Follow-up

Participants are monitored for safety and effectiveness after treatment

4 weeks

Treatment Details

Interventions

• MRI and advanced MRI sequences (Radiation)

Trial Overview The study is testing whether advanced MR imaging techniques can more accurately identify high-risk areas in malignant gliomas that might recur after treatment. The goal is also to see if these imaging methods can help design better radiation treatment plans and monitor changes in brain tumors.

Participant Groups

Group I: MRI Experimental Treatment 1 Intervention

The advanced MRI studies will be obtained at the time of the routinely scheduled preoperative planning MRI and/or the routinely scheduled pre-RT planning MRI at approximately 3±2 weeks after surgery. The routine sequences obtained for the planning MRI are standard of care. The advanced MRI sequences may or may not be additional as some have already been adopted into the standard of care imaging at MSKCC.

Find a Clinic Near You

Research Locations Nearby Select from list below to view details:

Memorial Sloan Kettering Cancer Center New York, NY

Who Is Running the Clinical Trial?

Memorial Sloan Kettering Cancer Center

Lead Sponsor

Trials

1998

Patients Recruited

602,000+

Findings from Research

NCBI (Pubmed)

pubmed.ncbi.nlm.nih.gov

Advanced MR Imaging in Neuro-oncology. Radbruch, A., Bendszus, M.[2018]

NCBI (Pubmed)

pubmed.ncbi.nlm.nih.gov

The role of advanced MR imaging in understanding brain tumour pathology. Price, SJ.[2007]

NCBI (Pubmed)

pubmed.ncbi.nlm.nih.gov

Modern preoperative imaging and functional mapping in patients with intracranial glioma. Sollmann, N., Zhang, H., Kloth, C., et al.[2023]

NCBI (Pubmed)

pubmed.ncbi.nlm.nih.gov

[Multimodal magnetic resonance imaging of brain tumors]. Guillevin, R., Menuel, C., Vallée, JN.[2011]

NCBI (Pubmed)

pubmed.ncbi.nlm.nih.gov

Conventional and advanced magnetic resonance imaging in patients with high-grade glioma. Pope, WB., Brandal, G.[2018]

NCBI (Pubmed)

pubmed.ncbi.nlm.nih.gov

Tailored magnetic resonance fingerprinting of post-operative pediatric brain tumor patients. Poojar, P., Qian, E., Jin, Z., et al.[2023]

NCBI (Pubmed)

pubmed.ncbi.nlm.nih.gov

Ultra-high-field sodium MRI as biomarker for tumor extent, grade and IDH mutation status in glioma patients. Regnery, S., Behl, NGR., Platt, T., et al.[2021]

NCBI (Pubmed)

pubmed.ncbi.nlm.nih.gov

GliMR: Cross-Border Collaborations to Promote Advanced MRI Biomarkers for Glioma. Clement, P., Booth, T., Borovečki, F., et al.[2022]

NCBI (Pubmed)

pubmed.ncbi.nlm.nih.gov

Patient‑derived orthotopic xenograft glioma models fail to replicate the magnetic resonance imaging features of the original patient tumor. Xue, W., Ton, H., Zhang, J., et al.[2021]

NCBI (Pubmed)

pubmed.ncbi.nlm.nih.gov

Advanced magnetic resonance imaging in glioblastoma: a review. Shukla, G., Alexander, GS., Bakas, S., et al.[2018]

NCBI (Pubmed)

pubmed.ncbi.nlm.nih.gov

Advanced MRI of adult brain tumors. Young, GS.[2022]

NCBI (Pubmed)

pubmed.ncbi.nlm.nih.gov

Novel Magnetic Resonance Imaging Techniques in Brain Tumors. Nechifor, RE., Harris, RJ., Ellingson, BM.[2015]

References

1. Germany pubmed.ncbi.nlm.nih.gov

Advanced MR Imaging in Neuro-oncology. [2018]

2. England pubmed.ncbi.nlm.nih.gov

The role of advanced MR imaging in understanding brain tumour pathology. [2007]

3. Germany pubmed.ncbi.nlm.nih.gov

Modern preoperative imaging and functional mapping in patients with intracranial glioma. [2023]

4. France pubmed.ncbi.nlm.nih.gov

[Multimodal magnetic resonance imaging of brain tumors]. [2011]

5. Italy pubmed.ncbi.nlm.nih.gov

Conventional and advanced magnetic resonance imaging in patients with high-grade glioma. [2018]

6. United States pubmed.ncbi.nlm.nih.gov

Tailored magnetic resonance fingerprinting of post-operative pediatric brain tumor patients. [2023]

7. Netherlands pubmed.ncbi.nlm.nih.gov

Ultra-high-field sodium MRI as biomarker for tumor extent, grade and IDH mutation status in glioma patients. [2021]

8. China pubmed.ncbi.nlm.nih.gov

GliMR: Cross-Border Collaborations to Promote Advanced MRI Biomarkers for Glioma. [2022]

9. Greece pubmed.ncbi.nlm.nih.gov

Patient‑derived orthotopic xenograft glioma models fail to replicate the magnetic resonance imaging features of the original patient tumor. [2021]

10. China pubmed.ncbi.nlm.nih.gov

Advanced magnetic resonance imaging in glioblastoma: a review. [2018]

11. United States pubmed.ncbi.nlm.nih.gov

Advanced MRI of adult brain tumors. [2022]

12. United States pubmed.ncbi.nlm.nih.gov

Novel Magnetic Resonance Imaging Techniques in Brain Tumors. [2015]