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Advanced MRI for Brain Tumors

N/A

Recruiting

Led By Robert Young, MD

Research Sponsored by Memorial Sloan Kettering Cancer Center

Eligibility Criteria Checklist

Specific guidelines that determine who can or cannot participate in a clinical trial

Must have

Age ≥ 18 years old

Suspected or Histopathologically proven diagnosis of high grade or low glioma or tumor is suspected to harbor an isocitrate dehydrogenase (IDH) mutation

Must not have

Any contraindication to gadolinium intravenous contrast as per standard Department of Radiology contrast guidelines

Unable to cooperate for MRI and/or radiation therapy planning

Timeline

Screening 3 weeks

Treatment Varies

Follow Up up to 5 years

Awards & highlights

No Placebo-Only Group

Summary

This trial is testing whether a new brain imaging technique is safe and effective in people with brain tumors.

Who is the study for?

This trial is for adults over 18 with suspected or confirmed high or low grade gliomas, which are types of brain tumors. They should be candidates for radiation therapy and able to consent to the study. It's not suitable for those allergic to MRI contrast agents, have contraindications to MRI like pacemakers, are pregnant/nursing, can't undergo an MRI due to extreme claustrophobia, or cannot cooperate during the procedure.

What is being tested?

The study is testing whether advanced MR imaging techniques can more accurately identify high-risk areas in malignant gliomas that might recur after treatment. The goal is also to see if these imaging methods can help design better radiation treatment plans and monitor changes in brain tumors.

What are the potential side effects?

Since this trial involves advanced MR imaging rather than drugs, side effects may include discomfort from lying still during the scan and anxiety or claustrophobia inside the scanner. There's a small risk of an allergic reaction to the gadolinium-based contrast agent used.

Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below

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I am 18 years old or older.

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My brain tumor is suspected to be serious or has a specific genetic change.

Exclusion Criteria

You may be eligible for the trial if you check “No” for criteria below:

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I am not allergic or have any issues with MRI contrast dye.

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I cannot undergo MRI or radiation therapy planning.

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I am currently pregnant or breastfeeding.

Timeline

Screening ~ 3 weeks3 visits

Treatment ~ Varies

Follow Up ~ up to 5 years

Screening ~ 3 weeks

Treatment ~ Varies

Follow Up ~up to 5 years

This trial's timeline: 3 weeks for screening, Varies for treatment, and up to 5 years for reporting.

Treatment Details

Awards & Highlights

No Placebo-Only Group

All patients enrolled in this study will receive some form of active treatment.

Trial Design

1Treatment groups

Experimental Treatment

Group I: MRIExperimental Treatment1 Intervention

The advanced MRI studies will be obtained at the time of the routinely scheduled preoperative planning MRI and/or the routinely scheduled pre-RT planning MRI at approximately 3±2 weeks after surgery. The routine sequences obtained for the planning MRI are standard of care. The advanced MRI sequences may or may not be additional as some have already been adopted into the standard of care imaging at MSKCC.

0 / 5Eligibility criteria met