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Radiotherapy Response Monitoring for Head and Neck Cancers

N/A

Recruiting

Led By Gregory J Czarnota, PhD, MD

Research Sponsored by Sunnybrook Health Sciences Centre

Eligibility Criteria Checklist

Specific guidelines that determine who can or cannot participate in a clinical trial

Must have

Timeline

Screening 3 weeks

Treatment Varies

Follow Up 5 years

Awards & highlights

Summary

In this study, PA imaging will be used to examine the physiological and physical changes in lymph node involvements of head and neck cancer during radiotherapy with or without chemotherapy. Our objective in this pilot study will be to evaluate if PA parameters change within the lymph node involvements during chemoradiation therapy over time. Our hope is to use this information to correlate the changes in measured PA parameters with radiological response.

Eligible Conditions

Head and Neck Cancers

Timeline

Screening ~ 3 weeks3 visits

Treatment ~ Varies

Follow Up ~ 5 years

Screening ~ 3 weeks

Treatment ~ Varies

Follow Up ~5 years

This trial's timeline: 3 weeks for screening, Varies for treatment, and 5 years for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.

Primary outcome measures

Correlation of response to treatment between photoacoustic parameters and final radiological outcome. measures of outcome.

Secondary outcome measures

Correlation between photoacoustic parameters and five-year overall survival.

Trial Design

1Treatment groups

Experimental Treatment

Group I: Radiotherapy Response MonitoringExperimental Treatment1 Intervention

Those undergoing radiation therapy treatment to their lymph nodes upon diagnosis of head and neck cancer

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Who is running the clinical trial?

Sunnybrook Health Sciences CentreLead Sponsor

671 Previous Clinical Trials

1,564,585 Total Patients Enrolled

Gregory J Czarnota, PhD, MDPrincipal InvestigatorSunnybrook Health Sciences Centre

6 Previous Clinical Trials

1,960 Total Patients Enrolled

~8 spots leftby Sep 2025

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