Popular Trials
Dexamethasone + Simvastatin for Neurotoxicity After Lymphoma Treatment
This trial is testing whether it is safe and feasible to give patients dexamethasone and simvastatin along with axicabtagene ciloleucel (a cancer treatment). Feasibility will be measured by whether patients are able to complete most of their treatments.
Device
CARA Support for Breast Cancer Radiotherapy
This trial is testing a new carbon-fiber device called CARA that supports the breast during radiation therapy. It aims to reduce skin damage and protect healthy tissues in patients receiving whole breast radiation. CARA works by positioning the breast to minimize skin folds and unnecessary radiation exposure. Earlier studies showed that CARA can reduce radiation dose to the lung and heart, and eliminate inframammary folds, which may reduce skin toxicity.
Popular Filters
Trials for Adenocarcinoma Patients
Metabolic Imaging Agent
Metabolic Imaging for Detecting Heart Damage After Radiation in Breast Cancer Patients
This trial uses advanced imaging techniques to detect early heart damage in women with left-sided breast cancer receiving radiation therapy. By observing how the heart processes a special substance, doctors can identify early signs of damage before it becomes severe.
Radiation
Biomarker Analysis for Prostate Cancer Radiotherapy Toxicity Prediction
This trial is testing a way to predict which prostate cancer patients will experience long-term genitourinary toxicity after radiation therapy, so that patients and doctors can make more informed decisions about treatment.
Proton Beam Therapy
Proton Therapy Spot Placement for Prostate Cancer
This trial aims to study the placement of proton spots during proton therapy for prostate cancer. The researchers will be using a technique called "Spot Delete" to control the placement of spots during treatment planning. They
Trials for Breast Cancer Patients
Metabolic Imaging Agent
Metabolic Imaging for Detecting Heart Damage After Radiation in Breast Cancer Patients
This trial uses advanced imaging techniques to detect early heart damage in women with left-sided breast cancer receiving radiation therapy. By observing how the heart processes a special substance, doctors can identify early signs of damage before it becomes severe.
Azeliragon + Chemotherapy for Breast Cancer
This trial is testing azeliragon, a drug that may reduce heart and brain damage caused by chemotherapy. It targets patients receiving anthracycline chemotherapy, which can harm the heart and cause cognitive decline. Azeliragon works by blocking a pathway involved in inflammation and cell damage. It is being studied as a potential treatment to slow disease progression in patients with mild Alzheimer's Disease.
Trials With No Placebo
Monoclonal Antibodies
Transplant Method for Sickle Cell Disease
This trial uses a combination of drugs and mild radiation to help children with sickle cell disease receive treatment from a sibling. It aims to reduce side effects while maintaining high cure rates. The focus is on children who need a safer treatment option.
Behavioral Intervention
Prophylactic Swallow Intervention for Head and Neck Cancer
This trial will compare the effectiveness of PRO-ACTIVE (high and low intensity) versus RE-ACTIVE swallowing therapy among 952 patients with HNC planning to undergo RT, using duration of feeding tube dependence after RT as the primary outcome.
Proton Beam Therapy
Proton Therapy for Anal Cancer
This trial is testing if Proton Therapy can reduce radiation exposure to healthy areas around anal cancer, aiming to lessen side effects compared to standard treatments. Proton therapy is an emerging treatment for cancer that may have distinct advantages over conventional radiotherapy, particularly in minimizing radiation dose to surrounding normal tissue.
View More Related Trials
Frequently Asked Questions
Introduction to toxicity
What are the top hospitals conducting toxicity research?
When it comes to clinical trials focused on toxicity, some of the top hospitals worldwide are contributing valuable research and advancements in this field. In Rochester, Minnesota, the renowned Mayo Clinic is currently undertaking three active toxicity trials. With a commitment to patient care and medical innovation, Mayo Clinic has established itself as a leader in healthcare. Moving south to Charleston, South carolina, the Medical University of South Carolina is also actively conducting three toxicity trials. This esteemed institution is known for its expertise in various medical specialties and its dedication to improving patient outcomes.
Meanwhile, in Minneapolis at the Masonic Cancer Center of the University of Minnesota, researchers are engaged in two ongoing studies addressing toxicity concerns. The center's mission extends beyond treatment protocols into groundbreaking research aimed at better understanding toxic effects associated with different interventions. Similarly driven by a strong focus on pediatric health is The Hospital for Sick Children located in Toronto; this hospital has committed itself to two current clinical trials that specifically target potential toxicities across diverse age groups.
Last but not least on our list is the University of Texas MD Anderson Cancer Center situated in Houston—a hub for cutting-edge cancer research—where scientists are currently involved in two active clinical trials centered on toxicity assessment. With their innovative approach towards personalized medicine and multidisciplinary collaboration between experts from various fields spanning oncology and pharmacology among others—they aim to redefine how we understand treatment side effects while striving tirelessly towards improving patients' quality of life.
These leading institutions collectively reflect an unwavering commitment to exploring new frontiers when it comes to studying drug-related side effects and other forms of toxicity commonly encountered during treatments or interventions across diverse populations.
Which are the best cities for toxicity clinical trials?
When it comes to toxicity clinical trials, several cities have emerged as leaders in this field of research. Toronto, Ontario leads the way with 9 active trials focused on studying interventions like reduced margin, abatacept, and PRO-ACTIVE EAT + EXERCISE. Washington, District of Columbia follows closely behind with 6 ongoing studies examining chemotherapy regimens that include ddAC, acetaminophen/APAP, and simvastatin. Boston, Massachusetts is also a prominent city for toxicity trials with 6 active studies investigating treatments such as anakinra, atorvastatin, and accelerated photon radiation therapy (XRT) group. Other noteworthy cities include Houston, Texas and Cleveland Ohio where researchers are exploring various interventions to address toxicity concerns in patients undergoing treatment for different conditions. These cities offer individuals the opportunity to participate in cutting-edge clinical trials that aim to enhance safety profiles and minimize adverse effects associated with medical interventions.
Which are the top treatments for toxicity being explored in clinical trials?
Clinical trials are actively investigating various treatments to address toxicity in patients. Some of the top contenders include:
- Daratumumab: 6 active trials, 134 all-time breast cancer trials, first listed in 2012.
- Belantamab mafodotin: 4 active trials, 26 all-time breast cancer trials, first listed in 2018.
- Lenalidomide: Currently involved in three ongoing breast cancer studies and has participated in a remarkable total of 280 clinical trials since its debut back in 2003.
These treatments show promise and signify significant progress towards managing toxicity effectively.
What are the most recent clinical trials for toxicity?
Recent clinical trials have made significant strides in addressing the issue of toxicity. One promising study focuses on a reduced elective dose combined with concurrent capecitabine/mitomycin C, aiming to minimize toxic side effects while maintaining treatment efficacy. Another trial examines high-dose ORC-13661 as a potential solution for toxicity management. Additionally, blinatumomab has shown promise in reducing adverse effects associated with certain treatments. A chemotherapy regimen inclusive of ddAC is being explored to mitigate toxicity concerns through careful drug selection and dosage optimization. Lastly, TARA-002 presents an intriguing avenue for managing toxicity-related complications. These ongoing trials hold great promise in improving patient outcomes by minimizing treatment-associated toxicities and enhancing quality of life.
What toxicity clinical trials were recently completed?
Several recent clinical trials have focused on toxicity, aiming to shed light on potential adverse effects of various treatments. These studies provide valuable insights into the safety profiles of different therapies and play a crucial role in patient care. While specific details vary depending on each trial's design, several noteworthy investigations deserve attention for their contributions in this area. Researchers completed a significant toxicity trial involving Uproleselan in October 2021, spearheaded by Washington University School of Medicine. Additionally, AgenTus Therapeutics concluded an important study examining agenT-797 toxicity levels back in January 2021. These trials highlight the commitment to understanding and managing treatment-related toxicities for improved patient outcomes while highlighting areas that warrant further investigation and refinement.