Trial Summary
What is the purpose of this trial?Investigators are conducting this study to test if temporarily and non-invasively stimulating the brain will affect the emotional response to stress in healthy participants.
Participants will perform a series of tasks while completing an MRI scan. After this, participants will be randomized to undergo transcranial magnetic stimulation (TMS) at two visits, undergoing active stimulation at one visit and undergoing 'sham' stimulation at another visit. Immediately following both stimulation sessions, participants will repeat the tasks during MRI scanning.
Eligibility Criteria
This trial is for healthy individuals interested in how brain stimulation might affect their emotional response to stress. Participants should be willing to undergo MRI scans and two sessions of transcranial magnetic stimulation (TMS), one active and one sham.Inclusion Criteria
I am between 30 and 50 years old.
Exclusion Criteria
I regularly take more than 2 non-insulin diabetes medications.
I have been taking certain medications regularly for the last 14 days.
Treatment Details
The study tests the effects of a non-invasive brain stimulation technique called continuous theta burst stimulation on managing stress and anxiety. It involves comparing active TMS with a placebo-like 'sham' version while participants complete tasks during an MRI scan.
2Treatment groups
Experimental Treatment
Group I: Sham then ActiveExperimental Treatment2 Interventions
In this arm, participants will first undergo sham theta burst stimulation (cTBS) at the first visit and then undergo active cTBS in the second visit.
Group II: Active then ShamExperimental Treatment2 Interventions
In this arm, participants will first undergo active theta burst stimulation (cTBS) at the first visit and then undergo sham cTBS in the second visit.
Find a clinic near you
Research locations nearbySelect from list below to view details:
University of Pittsburgh Medical CenterPittsburgh, PA
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Who is running the clinical trial?
University of PittsburghLead Sponsor
National Institute of Mental Health (NIMH)Collaborator