Music Listening for Bone Marrow Transplant
Recruiting in Palo Alto (17 mi)
Age: 18+
Sex: Any
Travel: May Be Covered
Time Reimbursement: Varies
Trial Phase: Academic
Recruiting
Sponsor: University of Colorado, Denver
Disqualifiers: Cognitive impairment, Psychosis, Hearing impairments, others
No Placebo Group
Trial Summary
What is the purpose of this trial?The goal of this trial is to develop an Independent Music Listening tool for stem cell transplant patients that have prolonged hospitalizations. The main questions it aims to answer are:
\[primary hypothesis or outcome measure 1\]? \[primary hypothesis or outcome measure 2\]?
Participants will use a self-guided music listening intervention of 1-hour daily music listening during their inpatient hsopitalization and delivered via web-based platform.
Will I have to stop taking my current medications?
The trial information does not specify whether you need to stop taking your current medications.
What data supports the effectiveness of the treatment Mindful Music Listening (MML) for bone marrow transplant patients?
Research shows that mindfulness meditation, which is part of Mindful Music Listening, can help reduce stress and improve symptoms in cancer patients undergoing stem cell transplants. Additionally, music therapy has been found to improve relaxation and reduce anxiety and pain in transplant patients, suggesting potential benefits for those undergoing bone marrow transplants.
12345Is music listening safe for people undergoing bone marrow transplants?
Music listening has been studied in various settings, including for patients undergoing bone marrow transplants, and is generally considered safe. It has been shown to improve mood and reduce stress without any reported harmful effects.
26789How is Mindful Music Listening (MML) different from other treatments for bone marrow transplant patients?
Mindful Music Listening (MML) is unique because it combines mindfulness (a mental practice of focusing on the present moment) with music listening to help improve mood and reduce stress during bone marrow transplant recovery. Unlike traditional treatments that may focus on medication or physical interventions, MML offers a non-invasive, holistic approach that can be used alongside other therapies to enhance emotional well-being.
2681011Eligibility Criteria
This trial is for patients undergoing a bone marrow transplant who will have long hospital stays. Participants should be willing to listen to music for an hour daily using a web-based platform during their inpatient stay.Inclusion Criteria
I am 18 years old or older.
Score ≥1 on the distress thermometer
Able to provide informed consent
+2 more
Exclusion Criteria
Significant and active cognitive conditions (e.g., major cognitive impairment), psychiatric conditions (e.g., active psychosis), or medical conditions (e.g., untreated significant hearing impairments) that would prevent the ability to provide informed consent or participate in the music listening intervention
Lack access to music streaming via smartphone, tablet, or computer and internet access.
Trial Timeline
Screening
Participants are screened for eligibility to participate in the trial
2-4 weeks
Treatment
Participants engage in a self-guided music listening intervention of 1-hour daily during their inpatient hospitalization
3-4 weeks
Daily music listening sessions
Follow-up
Participants are monitored for safety and effectiveness after treatment
4 weeks
Participant Groups
The study is testing Mindful Music Listening (MML), which involves self-guided, daily one-hour sessions of music listening delivered through a web-based platform, designed to support stem cell transplant patients.
2Treatment groups
Experimental Treatment
Active Control
Group I: Music InterventionExperimental Treatment1 Intervention
Group II: ControlActive Control1 Intervention
Find a Clinic Near You
Research Locations NearbySelect from list below to view details:
University of Colorado Anschutz Medical CampusAurora, CO
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Who Is Running the Clinical Trial?
University of Colorado, DenverLead Sponsor
References
Facing the challenges of hematopoietic stem cell transplantation with mindfulness meditation: a pilot study. [2022]The hematopoietic stem cell transplant (HSCT) experience is emotionally and physically stressful for cancer patients who undergo this procedure. Mindfulness-based interventions have been studied in patients with various diagnoses, including cancer, although minimal work has applied this intervention to hospitalized patients. Use of mindfulness meditation has potential to provide HSCT patients with coping skills to deal with unpleasant symptoms and an uncertain future. This exploratory study examined feasibility, physiological arousal, and psychological and physical symptoms in HSCT patients participating in a mindfulness meditation intervention that begins before and continues throughout hospitalization and involves one-on-one guided sessions and daily practice using a 17-minute meditation CD. Of the 20 participants, 78.9% completed the intervention. Statistically significant decreases in heart and respiratory rates and improvements in symptoms immediately before and after each session were found. These findings demonstrate feasibility and preliminary support of a mindfulness meditation intervention with symptomatic, hospitalized cancer patients.
A qualitative study of blood and marrow transplant patient experiences participating in art making and music listening. [2018]To explore patient experiences of engaging in art making or music listening while receiving treatment in a blood and marrow transplant clinic.
The effects of music therapy in patients with high-dose chemotherapy and stem cell support: a randomized pilot study. [2018]Patients with high dose chemotherapy (HDC) with autologous stem cell transplantation (ASCT) are highly distressed. Psycho-oncological support might be beneficial but is not routinely provided. Our aim was to investigate whether music therapy (MT) in addition to standard supportive treatment had any effect on quality of life, depression, anxiety, side effects of therapy, medication, and immunological changes during and within three months after HDC plus ASCT.
Music interventions for psychological and physical outcomes in cancer: a systematic review and meta-analysis. [2021]A systematic review and meta-analysis to examine the effect of music interventions on psychological and physical outcome measures in cancer patients.
The effect of music therapy on relaxation, anxiety, pain perception, and nausea in adult solid organ transplant patients. [2019]Organ transplant recipients characteristically experience low levels of relaxation and high levels of anxiety, pain, and nausea. Although music therapy has demonstrated effectiveness in ameliorating these types of conditions with patients in other areas of medical hospitals, no studies have evaluated the effects of music therapy on solid organ transplant patients. The purpose of this study was to assess the impact of music therapy on anxiety, relaxation, pain, and nausea levels in recovering patients on the adult transplant unit of the hospital utilizing a pre-posttest design. Participants (N = 58) received an individual 15-35 minute music therapy session consisting of live patient-preferred music and therapeutic social interaction. To remain consistent with the hospital's evaluative instruments during this pilot study, participants' self-reported levels of anxiety, relaxation, pain, and nausea, were based on separate 10-point Likert-type scales. The principal investigator observed affect and verbalizations at pre and posttest. Results indicated there were significant improvements in self-reported levels of relaxation, anxiety (both p
Effects of Making Art and Listening to Music on Symptoms Related to Blood and Marrow Transplantation. [2017]To understand the benefits of making art and listening to music and whether those activities may be beneficial for reducing symptoms associated with blood and marrow transplantation. .
Reduction of distress associated with paediatric bone marrow transplant: complementary health promotion interventions. [2022]Despite numerous medical advances in stem cell/bone marrow transplantation (BMT) for children with malignancies or other catastrophic disorders, BMT remains a prolonged and physically demanding procedure that can be associated with high levels of distress for patients and their families. This paper reviews work from our laboratory that documents the high levels of somatic distress and mood disturbance experienced by patients undergoing the procedure, and points to the need for the development of novel interventions to reduce BMT-related distress. Issues of instrumentation and methodology for outcomes assessment are highlighted. Research is reviewed to support the potential benefits of a number of techniques from the field of complementary medicine (relaxation/imagery; massage, humour therapy, expressive therapy) for reduction of transplant-related distress. Finally, we described a series of studies in which complementary health promotion techniques were assessed in pilot trials. Based on patient and parent perception of helpfulness, two complementary treatments, massage and humour therapy, emerged as the most promising approaches for use in the BMT setting and are now the focus of a randomized clinical trial.
Music therapy for patients who have undergone hematopoietic stem cell transplant. [2021]Objectives. This study examines the short- and long-term QOL benefits of a music therapy intervention for patients recovering from hematopoietic stem cell transplantation (HSCT). Methods. Ninety allogeneic HSCT patients, after transplant, were randomized to receive ISO-principle (i.e., mood matching) based music therapy (MT; n = 29), unstructured music (UM; n = 30), or usual care (UC; n = 31) for four weeks. The ISO principle posits that patients may shift their mood from one state to another by listening to music that is "equal to" the individual's initial mood state and subsequently listening to music selections that gradually shift in tempo and mood to match the patient's desired disposition. Participants in MT and UM groups developed two audio CDs to help them feel more relaxed and energized and were instructed to use the CDs to improve their mood as needed. Short-term effects on mood and long-term effects on QOL were examined. Results. MT and UM participants reported improved mood immediately after listening to CDs; the within-group effect was greater for UM participants compared to MT participants. Participant group was not associated with long-term QOL outcomes. Conclusions. Music listening improves mood acutely but was not associated with long-term benefits in this study.
Impact of a Music Intervention on Quality of Life in Breast Cancer Patients Undergoing Chemotherapy: A Randomized Clinical Trial. [2021]Background: Music can influence human behavior and may be used as a complementary therapy in health care. Objectives: To assess the effect of music interventions on symptoms, adverse events, and quality of life (QoL) of breast cancer patients undergoing chemotherapy (CT). Design: Nonblinded, randomized clinical trial. Women with breast cancer undergoing adjuvant CT were randomized into 2 groups-Group Music (GM) or Group Control (GC)-and followed during the first 3 cycles of treatment. Measurements: Sociodemographic data, WHOQOL-BREF, BDI-II, BAI, and Chemotherapy Toxicity Scale were assessed. Patients were evaluated after each session of the first 3 CT cycles. GM underwent a 30-minute musical intervention before CT. There was no intervention in the GC. Continuous data were analyzed by Student's t test, and χ2 test was used to compare qualitative variables. Results: Higher QoL scores on functional scales were observed for the GM in comparison to the GC after the first and third sessions of CT. Depression (P < .001) and anxiety scores (P < .001) and vomiting (P < .01) incidence were lower for the GM in the third session of CT. All the participants in the GM reported positive changes in life in the Subjective Impression of the Subject questionnaire, as well as improvement in fatigue and reduced stress levels. Conclusions: Improvements in QoL, anxiety, depression, and incidence of vomiting were associated with the music intervention, suggesting a positive effect of the music intervention on adverse events of cancer CT.
The effectiveness of music therapy for patients with cancer: A systematic review and meta-analysis. [2021]To assess the effectiveness of music therapy on the quality of life, anxiety, depression and pain of patients with cancer.
The Effect of Mindfulness-Based Music Therapy on Attention and Mood in Women Receiving Adjuvant Chemotherapy for Breast Cancer: A Pilot Study. [2015]To explore the efficacy of mindfulness- based music therapy (MBMT) to improve attention and decrease mood distress experienced by women with breast cancer receiving adjuvant chemotherapy.