What is the mechanism of action of this treatment?

Common treatments for connective tissue disorders often aim to enhance collagen synthesis, which is crucial for maintaining the structural integrity and function of connective tissues. For instance, natural product supplements are being studied for their potential to potentiate collagen synthesis when combined with collagen protein ingestion. These supplements may stimulate collagen production through various pathways, including the upregulation of growth factors and modulation of enzymatic activity involved in collagen breakdown. This is significant for patients with connective tissue disorders as improved collagen synthesis can aid in tissue repair, reduce symptoms, and enhance overall tissue resilience.

What side effects are associated with this type of intervention?

Common treatments for connective tissue issues that aim to stimulate collagen synthesis include natural product supplements, collagen peptides, and glucocorticoids. Natural product supplements and collagen peptides are generally well-tolerated, but some individuals may experience mild gastrointestinal discomfort or allergic reactions. Glucocorticoids, while effective, can have more significant side effects such as weight gain, osteoporosis, hypertension, and increased risk of infections. It is important to consult with a healthcare provider to weigh the benefits and risks of these treatments.

What prior FDA approvals exist?

FDA-approved treatments for connective tissue disorders often focus on managing symptoms and slowing disease progression. For instance, protein replacement therapy using recombinant collagen type VII has shown promise in preclinical studies for conditions like epidermolysis bullosa. Additionally, drugs like D-penicillamine have been studied for their effects on collagen synthesis in arthritic conditions. While specific natural product supplements to potentiate collagen synthesis are still under investigation, these examples highlight the ongoing efforts to develop effective treatments for connective tissue disorders.

What other types of research exist?

Promising novel alternatives for connective tissue patients in 2024 include: 1) Intra-articular sprifermin, which has shown efficacy in reducing cartilage loss and increasing cartilage gain in osteoarthritis patients. 2) Recombinant human fibroblast growth factor 18 (rhFGF18), which is being investigated for its potential to improve cartilage thickness. 3) Omega-3 fatty acid supplements, which have shown modest improvements in symptoms and ocular surface health in patients with dry eye and systemic immune diseases. These alternatives target joint health and collagen synthesis pathways, offering potential benefits for connective tissue patients.

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Nutritional Supplement for Connective Tissue Health

N/A

Recruiting

Led By Keith Baar, PhD

Research Sponsored by University of California, Davis

Eligibility Criteria Checklist

Specific guidelines that determine who can or cannot participate in a clinical trial

Must have

Be between 18 and 65 years old

Timeline

Screening 3 weeks

Treatment Varies

Follow Up 60 minutes post-exercise

Summary

This trial tests if a natural supplement can help the body make more collagen when taken with collagen protein. It targets people who want better skin, joint, or ligament health. The supplement works by boosting collagen production in the body.

Who is the study for?

This trial is for young healthy adults aged 18-35 who are not pregnant, do not smoke, and are not on medications that could affect the study results. It's designed to see if a new nutritional supplement can help the body make more collagen after taking collagen protein.

What is being tested?

Researchers are testing a natural product supplement against a placebo to see if it enhances collagen production in the body when taken with collagen protein. Participants' blood samples will be used to treat lab-grown ligaments and measure effects.

What are the potential side effects?

Since this trial involves dietary supplements generally recognized as safe (GRAS), side effects may be minimal but could include digestive discomfort or allergic reactions depending on individual sensitivities.

Timeline

Screening ~ 3 weeks3 visits

Treatment ~ Varies

Follow Up ~ 60 minutes post-exercise

Screening ~ 3 weeks

Treatment ~ Varies

Follow Up ~60 minutes post-exercise

This trial's timeline: 3 weeks for screening, Varies for treatment, and 60 minutes post-exercise for reporting.

Treatment Details

Study Objectives

Study objectives can provide a clearer picture of what you can expect from a treatment.

Primary study objectives

Collagen protein synthesis

Secondary study objectives

Collagen content of ligament constructs

Strength of ligament constructs

Trial Design

2Treatment groups

Experimental Treatment

Placebo Group

Group I: Natural Product SupplementExperimental Treatment1 Intervention

The participant will consume a dose of hydrolyzed collagen (20g) supplemented with vitamin C (100 mg), epicatechin (75 mg), vitamin E (350 iU) and stevia extract (225 mg).

Group II: PlaceboPlacebo Group1 Intervention

The participant will consume a dose of hydrolyzed collagen (20g) supplemented with vitamin C (100 mg) and sweetener.

Do I qualify?Apply below to find out

Research Highlights

Information in this section is not a recommendation. We encourage patients to speak with their healthcare team when evaluating any treatment decision.

Mechanism Of Action

Side Effect Profile

Prior Approvals

Other Research

Common treatments for connective tissue disorders often aim to enhance collagen synthesis, which is crucial for maintaining the structural integrity and function of connective tissues. For instance, natural product supplements are being studied for their potential to potentiate collagen synthesis when combined with collagen protein ingestion. These supplements may stimulate collagen production through various pathways, including the upregulation of growth factors and modulation of enzymatic activity involved in collagen breakdown. This is significant for patients with connective tissue disorders as improved collagen synthesis can aid in tissue repair, reduce symptoms, and enhance overall tissue resilience.

Effects of Different Vitamin C-Enriched Collagen Derivatives on Collagen Synthesis.Modulation of MMP-2 and MMP-9 through connected pathways and growth factors is critical for extracellular matrix balance of intra-articular ligaments.Birefringence of collagen fibres in rat calcaneal tendons treated with acupuncture during three phases of healing.