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Nutritional Supplement for Connective Tissue Health
N/A
Recruiting
Led By Keith Baar, PhD
Research Sponsored by University of California, Davis
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial Must have
Be between 18 and 65 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up 60 minutes post-exercise
Summary
This trial tests if a natural supplement can help the body make more collagen when taken with collagen protein. It targets people who want better skin, joint, or ligament health. The supplement works by boosting collagen production in the body.
Who is the study for?
This trial is for young healthy adults aged 18-35 who are not pregnant, do not smoke, and are not on medications that could affect the study results. It's designed to see if a new nutritional supplement can help the body make more collagen after taking collagen protein.
What is being tested?
Researchers are testing a natural product supplement against a placebo to see if it enhances collagen production in the body when taken with collagen protein. Participants' blood samples will be used to treat lab-grown ligaments and measure effects.
What are the potential side effects?
Since this trial involves dietary supplements generally recognized as safe (GRAS), side effects may be minimal but could include digestive discomfort or allergic reactions depending on individual sensitivities.
Timeline
Screening ~ 3 weeks3 visits
Treatment ~ Varies
Follow Up ~ 60 minutes post-exercise
Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~60 minutes post-exercise
Treatment Details
Study Objectives
Study objectives can provide a clearer picture of what you can expect from a treatment.Primary study objectives
Collagen protein synthesis
Secondary study objectives
Collagen content of ligament constructs
Strength of ligament constructs
Trial Design
2Treatment groups
Experimental Treatment
Placebo Group
Group I: Natural Product SupplementExperimental Treatment1 Intervention
The participant will consume a dose of hydrolyzed collagen (20g) supplemented with vitamin C (100 mg), epicatechin (75 mg), vitamin E (350 iU) and stevia extract (225 mg).
Group II: PlaceboPlacebo Group1 Intervention
The participant will consume a dose of hydrolyzed collagen (20g) supplemented with vitamin C (100 mg) and sweetener.
Research Highlights
Information in this section is not a recommendation. We encourage patients to speak with their healthcare team when evaluating any treatment decision.Mechanism Of Action
Side Effect Profile
Prior Approvals
Other Research
Common treatments for connective tissue disorders often aim to enhance collagen synthesis, which is crucial for maintaining the structural integrity and function of connective tissues. For instance, natural product supplements are being studied for their potential to potentiate collagen synthesis when combined with collagen protein ingestion.
These supplements may stimulate collagen production through various pathways, including the upregulation of growth factors and modulation of enzymatic activity involved in collagen breakdown. This is significant for patients with connective tissue disorders as improved collagen synthesis can aid in tissue repair, reduce symptoms, and enhance overall tissue resilience.
Effects of Different Vitamin C-Enriched Collagen Derivatives on Collagen Synthesis.Modulation of MMP-2 and MMP-9 through connected pathways and growth factors is critical for extracellular matrix balance of intra-articular ligaments.Birefringence of collagen fibres in rat calcaneal tendons treated with acupuncture during three phases of healing.
Effects of Different Vitamin C-Enriched Collagen Derivatives on Collagen Synthesis.Modulation of MMP-2 and MMP-9 through connected pathways and growth factors is critical for extracellular matrix balance of intra-articular ligaments.Birefringence of collagen fibres in rat calcaneal tendons treated with acupuncture during three phases of healing.
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Who is running the clinical trial?
AmpHP, IncUNKNOWN
University of California, DavisLead Sponsor
946 Previous Clinical Trials
4,756,118 Total Patients Enrolled
2 Trials studying Exercise
12 Patients Enrolled for Exercise
Keith Baar, PhDPrincipal InvestigatorUniversity of California, Davis
6 Previous Clinical Trials
134 Total Patients Enrolled
1 Trials studying Exercise
12 Patients Enrolled for Exercise