Light Therapy for Depression

Recruiting in Palo Alto (17 mi)

Overseen byAndrew Elliott, MD

Age: < 65

Sex: Any

Travel: May Be Covered

Time Reimbursement: Varies

Trial Phase: Academic

Waitlist Available

Sponsor: St. Jude Children's Research Hospital

No Placebo Group

Trial Summary

What is the purpose of this trial?

The participants are being asked to be in this clinical trial, a type of research study, because the participants are going to have a hematopoietic stem cell transplant (HSCT) in the near future. Participants that get HSCT's often get depression and/or suffer from depressive symptoms, tiredness, and sleep disturbances. Primary Objective To evaluate the efficacy of BL therapy for the treatment of depression in children and adolescents undergoing hematopoietic stem cell transplant. Secondary Objectives * To evaluate the temporal effect and magnitude of BL vs. DL therapy on depression in pediatric patients undergoing HSCT. * To evaluate the efficacy of BL therapy for the treatment of fatigue in children and adolescents undergoing hematopoietic stem cell transplant. * To evaluate the response of BL therapy versus DL on sleep quality. Exploratory Objectives * To compare incidence of positive delirium screenings between those receiving BL therapy versus DL * To evaluate participant and caregiver perceptions of the acceptability, ease of use, and risks/benefits of the use of Light Therapy Glasses during HSCT utilizing qualitative interviews.

Research Team

Andrew Elliott, MD

Principal Investigator

St. Jude Children's Research Hospital

Eligibility Criteria

This trial is for children and adolescents who are about to receive a hematopoietic stem cell transplant (HSCT) and may experience depression, fatigue, or sleep issues. Specific eligibility criteria details were not provided.

Inclusion Criteria

I or my primary caregiver can read and write in English or Spanish.

I speak English.

I am scheduled for a stem cell transplant from a donor in the next 7 to 10 days.

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Exclusion Criteria

I speak English and can participate in an interview.

I am taking medication that increases my skin's sensitivity to light.

Inability or unwillingness of research participant or legal guardian/representative to give written informed consent

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Treatment Details

Interventions

Light Therapy (Behavioural Intervention)

Trial OverviewThe study tests the effectiveness of Light Therapy using an Ayo wearable device to treat depression in pediatric patients undergoing HSCT. It compares Bright Light (BL) therapy with Dim Light (DL), also looking at effects on fatigue and sleep quality.

Participant Groups

2Treatment groups

Active Control

Group I: Group 1-A bright blue-spectrum white light (BLActive Control1 Intervention

Participants will receive therapy with bright blue-spectrum white light (BL) for up to thirty minutes each day for 28 days during their HSCT related hospital admission

Group II: Group 2- A dim blue-spectrum white light control (DLActive Control1 Intervention

Participants will receive therapy with dim blue-spectrum white light control (DL) for up to thirty minutes each day for 28 days during their HSCT related hospital admission