Resilience-Based Intervention for HIV/AIDS Stigma

N/A

Waitlist Available

Led By Xiaoming Li, PhD

Research Sponsored by University of South Carolina

Eligibility Criteria Checklist

Specific guidelines that determine who can or cannot participate in a clinical trial

Must have

Be older than 18 years old

Timeline

Screening 3 weeks

Treatment Varies

Follow Up 7 waves over 36 months

Awards & highlights

No Placebo-Only Group

Summary

This trial will test a resilience-based intervention to reduce HIV-related stigma in Guangxi, China. The primary outcome is viral suppression among people living with HIV (PLWH), and the intermediate outcomes include resilience resources at the levels of individuals, the PLWH's real or surrogate family members, and healthcare facilities, as well as chronic stress response and adherence to treatment and care.

Who is the study for?

The 'Rise-up' trial is for adults over 18 with HIV or AIDS, a detectable viral load, and willing to involve a family member. They must be able to provide hair samples, allow medical chart access, and not plan on relocating soon. Those mentally or physically unable to participate or involved in other studies are excluded.

What is being tested?

This study tests a resilience-based intervention aimed at reducing HIV-related stigma among patients, their families, and healthcare providers in China. It uses a stepped-wedge design to measure outcomes like viral suppression and treatment adherence.

What are the potential side effects?

Since this trial focuses on psychosocial interventions rather than medications, traditional side effects are not applicable. However, participants may experience emotional discomfort when discussing sensitive topics related to HIV/AIDS stigma.

Timeline

Screening ~ 3 weeks3 visits

Treatment ~ Varies

Follow Up ~ 7 waves over 36 months

Screening ~ 3 weeks

Treatment ~ Varies

Follow Up ~7 waves over 36 months

This trial's timeline: 3 weeks for screening, Varies for treatment, and 7 waves over 36 months for reporting.

Treatment Details

Study Objectives

Study objectives can provide a clearer picture of what you can expect from a treatment.

Primary study objectives

PLWH: change of CD4 counts at 36 months follow up

PLWH: change of viral load at 36 months follow up

Secondary study objectives

Family: change of intersecting stigma measures at 36 months follow up

Family: change of mental health measures at 36 months follow up

Family: change of quality of life measures at 36 months follow up

+19 more

Awards & Highlights

No Placebo-Only Group

All patients enrolled in this study will receive some form of active treatment.

Trial Design

3Treatment groups

Experimental Treatment

Group I: PLWH intervention sessionsExperimental Treatment1 Intervention

The PLWH in this arm will receive five 2-hour intervention sessions delivered over five weeks (one session per week) in the clinics. Two trained facilitators will deliver the materials through interactive trainings that include multimedia presentations, group discussions, role-play, personal testimonies, and/or games. The same two facilitators will deliver all five sessions within a clinic to increase group cohesion and rapport with PLWH. The goal of this intervention is to assist PLWH in identifying and developing internal and external resilience resources to aid in coping HIV stigma.

Group II: Health care provider interventionExperimental Treatment1 Intervention

The HCP intervention curriculum consists of four 1.5-hour sessions (e.g., one per week) that will be delivered in small groups in the clinic setting by trained facilitators (e.g., health educators from Guangxi CDC). The delivery schedule and format will be flexible and individually tailored (e.g., four sessions can be given one per week or consolidated into two longer sessions). The goal of this intervention is to reduce the institutional stigmatizing attitudes and practices toward PLWH and other social identities, such as MSM, sex workers, and drug users, and improving the provider-patient relationships.

Group III: Family member interventionExperimental Treatment1 Intervention

The intervention sessions for family members will be similar to PLWH sessions in terms of format and content and will be led by trained facilitators. Family member intervention sessions will emphasize supporting PLWH to cope with HIV-related stigma and to improve their clinical outcomes. The goal of this intervention is to provide social support for PLWH's resilience building as well as foster resilience at the family level.

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