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Cardiac Screening for Hodgkin's Lymphoma Survivors

N/A

Waitlist Available

Led By Andrea K. Ng, MD

Research Sponsored by Dana-Farber Cancer Institute

Eligibility Criteria Checklist

Specific guidelines that determine who can or cannot participate in a clinical trial

Must have

Relapse-free interval of more than 1 year

Patients treated at Brigham and Women's Hospital or Dana-Farber Cancer Institute for Hodgkin's disease with mediastinal irradiation

Must not have

Relapses within 1 year

Current age less than 15 years of age

Timeline

Screening 3 weeks

Treatment Varies

Follow Up 3 years

Awards & highlights

No Placebo-Only Group

Summary

This trial is testing whether a cardiac screening program for Hodgkin's disease survivors is possible and effective. It will also look for cardiac risk factors that could be improved with lifestyle changes or medication.

Who is the study for?

This trial is for survivors of Hodgkin's disease who were treated with chest radiation at Brigham and Women's Hospital or Dana-Farber Cancer Institute, are over 15 years old, have been in remission for more than a year, and it has been five or more years since their initial treatment.

What is being tested?

The study aims to establish a heart screening program for Hodgkin's disease survivors. It involves checking the heart using echo/stress echo tests to identify potential risks and improve quality of life through lifestyle changes or medication if needed.

What are the potential side effects?

Since this trial focuses on cardiac screening rather than drug intervention, there are no direct side effects from medications. However, stress during an echo test may cause temporary discomfort or anxiety.

Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below

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I have been free from cancer for more than a year.

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I received treatment for Hodgkin's disease with chest radiation at Brigham and Women's Hospital or Dana-Farber Cancer Institute.

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I am 15 years old or older.

Exclusion Criteria

You may be eligible for the trial if you check “No” for criteria below:

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My condition worsened within a year of treatment.

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I am younger than 15 years old.

Timeline

Screening ~ 3 weeks3 visits

Treatment ~ Varies

Follow Up ~ 3 years

Screening ~ 3 weeks

Treatment ~ Varies

Follow Up ~3 years

This trial's timeline: 3 weeks for screening, Varies for treatment, and 3 years for reporting.

Treatment Details

Study Objectives

Study objectives can provide a clearer picture of what you can expect from a treatment.

Primary study objectives

To determine the feasibility of a cardiac screening program in patients who are 5 to 10 years our from initial mediastinal irradiation for Hodgkin's disease.

Secondary study objectives

To prospectively collect data on the prevalence of modifiable cardiac risk factors and the spectrum of cardiac structural abnormalities in this patient populations

to correlate cardiac structural abnormalities with level of fatigue.

to correlate cardiac structural abnormalities with quality of life

Awards & Highlights

No Placebo-Only Group

All patients enrolled in this study will receive some form of active treatment.

Trial Design

1Treatment groups

Experimental Treatment

Group I: Cardiac screeningExperimental Treatment1 Intervention

Interventions: Participants will * meet with study cardiologist * undergo cardiac risk factors screening * undergo resting and stress echocardiogram (echo and stress echo)

0 / 5Eligibility criteria met