Watermelon for High Blood Pressure

(WMBP Trial)

Recruiting in Palo Alto (17 mi)

Overseen by Indika Edirisinghe, Ph.D.

Age: 18+

Sex: Any

Travel: May Be Covered

Time Reimbursement: Varies

Trial Phase: Academic

Waitlist Available

Sponsor: Clinical Nutrition Research Center, Illinois Institute of Technology

Trial Summary

What is the purpose of this trial?

1. Primary outcome: To evaluate the dose response effects of watermelon flesh in regulating Blood Pressure (BP) in individuals with pre-hypertension. 2. Secondary outcomes: To study the dose-response effects of watermelon flesh intake on cardio-metabolic risk factors including plasma metabolic markers, lipid profile and nitrate/nitrite levels in individuals with pre-hypertension.

Eligibility Criteria

This trial is for healthy overweight/obese adults aged 25-65 with slightly elevated blood pressure but no history of serious health issues. Participants should be nonsmokers, not on a vegetarian diet, and have stable weight without plans to lose more. They shouldn't consume certain supplements or medications that affect blood pressure or metabolism.

Inclusion Criteria

My fasting blood sugar is between 100 and 125 mg/dL, indicating prediabetes.

Your blood pressure is between 120-160 over 80-100 at the screening visit.

I have no history of major organ or metabolic diseases.

Exclusion Criteria

Your blood pressure is not well controlled and is too high.

You have given blood in the last 3 months.

You drink a lot of coffee or tea, more than 5 cups per day.

Participant Groups

The study tests how different amounts of watermelon flesh impact blood pressure in people with pre-hypertension. It also looks at the effects on heart-related risk factors like cholesterol and metabolic markers. Participants will receive one of two doses of watermelon flesh or a control treatment.

Group I: Watermelon flesh Dose 1 Active Control 1 Intervention

1 cup watermelon flesh, \~152 g

Group II: Watermelon flesh Dose 2 Active Control 1 Intervention

2 cups watermelon flesh, \~304 g

Group III: Control Placebo Group 1 Intervention

Calorie-matched control beverage

Find a Clinic Near You

Research Locations Nearby Select from list below to view details:

Clinical Nutrition Research Center Chicago, IL

Who Is Running the Clinical Trial?

Clinical Nutrition Research Center, Illinois Institute of Technology Lead Sponsor

National Watermelon Promotion Board Collaborator

References