Exercise for Type 2 Diabetes
(DYNAMMO-T2DEX Trial)

Recruiting in Palo Alto (17 mi)

Overseen byJohn Kirwan, PhD

Age: 18 - 65

Sex: Any

Travel: May Be Covered

Time Reimbursement: Varies

Trial Phase: Academic

Waitlist Available

Sponsor: Pennington Biomedical Research Center

No Placebo Group

Approved in 1 Jurisdiction

Trial Summary

What is the purpose of this trial?

Insulin promotes the clearance of sugars from the blood into skeletal muscle and fat cells for use as energy; it also promotes storage of excess nutrients as fat. Type 2 diabetes occurs when the cells of the body become resistant to the effects of insulin, and this causes high blood sugar and contributes to a build-up of fat in muscle, pancreas, liver, and the heart. Understanding how insulin resistance occurs will pave the way for new therapies aimed at preventing and treating type 2 diabetes. Mitochondria are cellular structures that are responsible for turning nutrients from food, into the energy that our cells run on. As a result, mitochondria are known as "the powerhouse of the cell." Mitochondria are dynamic organelles that can move within a cell to the areas where they are needed, and can fuse together to form large, string-like, tubular networks or divide into small spherical structures. The name of this process is "mitochondrial dynamics" and the process keeps the cells healthy. However, when more food is consumed compared to the amount of energy burned, mitochondria may become overloaded and dysfunctional resulting in a leak of partially metabolized nutrients that can interfere with the ability of insulin to communicate within the cell. This may be a way for the cells to prevent further uptake of nutrients until the current supply has been exhausted. However, long term overload of the mitochondria may cause blood sugar levels to rise and lead to the development of type 2 diabetes. This study will provide information about the relationship between mitochondrial dynamics, insulin resistance and type 2 diabetes.

Research Team

John Kirwan, PhD

Principal Investigator

Pennington Biomedical Research Center

Eligibility Criteria

This trial is for adults with Type 2 Diabetes who have a Body Mass Index (BMI) between 25 and 40 kg/m², an HbA1C level below 8.5%, and lead a sedentary lifestyle. It's not open to those currently on diabetes medication or smokers.

Inclusion Criteria

I lead a mostly inactive lifestyle.

Body Mass Index (BMI) between 25 and 50 kg/m2

HbA1C < 10%

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Exclusion Criteria

I have type 1 diabetes or need insulin therapy.

BMI >50 kg/m2

Smoking

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Treatment Details

Interventions

Exercise (Behavioural Intervention)

Trial OverviewThe study investigates how exercise affects the mitochondria in muscle cells of people with Type 2 Diabetes, which could influence insulin resistance and blood sugar levels, potentially leading to new treatments.

Participant Groups

2Treatment groups

Experimental Treatment

Active Control

Group I: exerciseExperimental Treatment1 Intervention

12 week exercise program, 5 days/week, 60 min/day

Group II: standard of careActive Control1 Intervention

12 week standard of care recommendations