Trial Summary
What is the purpose of this trial?This study aims to investigate the impact of accelerated transcranial magnetic stimulation (TMS) on brain function and behavior in patients with focal cervical dystonia. Previous research demonstrated that individualized TMS improved writing behavior in focal hand dystonia after one session. In this study, we aim to expand the application on TMS on focal cervical dystonia. The current study administers four TMS sessions in a day. The research involves 9 in-person visits. The effect of TMS will be assessed using functional MRI brain scans and behavioral measurements. The risk of TMS includes seizures; the potential risk of seizures from TMS is mitigated through careful screening, adhering to safety guidelines. The study's main benefit is enhancing dystonic behavior and deepening the understanding of brain changes caused by TMS in cervical dystonia, paving the way for further advancements in clinical therapy for this condition.
Eligibility Criteria
This trial is for individuals with conditions like isolated focal hand dystonia, general dystonia, or torticollis. Participants should be able to attend 10 in-person visits and undergo MRI scans and behavior analysis. The study excludes those at risk of seizures or who don't meet the safety guidelines for TMS.Treatment Details
The study tests whether four sessions of accelerated transcranial magnetic stimulation (TMS) can improve brain function and reduce symptoms in patients with focal hand dystonia. It includes fMRI brain scans before and after treatment to observe changes.
2Treatment groups
Active Control
Placebo Group
Group I: TMS to primary somatosensory cortexActive Control1 Intervention
Participants received TMS sessions at primary somatosensory cortex
Group II: sham TMSPlacebo Group1 Intervention
Participants receive sham TMS
Find a clinic near you
Research locations nearbySelect from list below to view details:
Duke University Health SystemDurham, NC
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Who is running the clinical trial?
Duke UniversityLead Sponsor
American Academy of NeurologyCollaborator