Trial Summary
What is the purpose of this trial?Idiopathic pulmonary fibrosis (IPF) is a lung disease that limits the ability to breathe enough for a good workout. One way to improve the exercise training is to reduce the number of muscles being trained together. By training one leg at a time, the patient does not have to breathe as much allowing each leg a better workout. Our groundwork suggests it may work in patients with IPF. This study will help decide whether one-legged exercise training is better at improving a patient's exercise endurance compared to the usual way of exercising with both legs at the same time.
Do I need to stop taking my current medications for this trial?The trial protocol does not specify whether you need to stop taking your current medications.
Is one-leg cycle training a promising treatment for idiopathic pulmonary fibrosis?Yes, one-leg cycle training is promising because it can improve oxygen uptake and physical capacity, which are important for people with lung conditions like idiopathic pulmonary fibrosis.12357
What safety data exists for one-legged and two-legged cycle training in idiopathic pulmonary fibrosis?The available research primarily focuses on chronic obstructive pulmonary disease (COPD), but it provides insights into the safety and benefits of one-legged and two-legged cycle training. Studies indicate that one-legged cycle training can lead to greater improvements in peak oxygen uptake compared to two-legged training, with no significant adverse effects reported. General exercise training, including limb exercises, is associated with sustained improvements in quality of life and reduced hospitalization risk in COPD patients. Although specific safety data for idiopathic pulmonary fibrosis (IPF) is limited, exercise training, including aerobic and muscle strengthening, is recommended for improving quality of life and physical capacity in stable IPF patients. The harm-benefit balance of exercise training appears favorable based on available data.12567
What data supports the idea that One-Legged vs Two-Legged Cycle Training for Idiopathic Pulmonary Fibrosis is an effective treatment?The available research shows that one-legged cycle training can lead to better improvements in physical capacity compared to two-legged cycle training, especially in conditions like chronic obstructive pulmonary disease (COPD). For example, one study found that one-legged training increased the ability to use oxygen and work rate more than two-legged training. Although the studies focus on COPD, they suggest that similar benefits might be seen in idiopathic pulmonary fibrosis (IPF) since both conditions affect the lungs and breathing. Additionally, exercise training in general, including cycling, is recommended for improving quality of life and physical capacity in people with IPF.12457
Eligibility Criteria
This trial is for stable patients with confirmed idiopathic pulmonary fibrosis who are enrolled in a pulmonary rehab program. It's not suitable for those who've had a recent exacerbation, finished rehab within the last 6 months, or have other health issues that could make rehab unsafe.Inclusion Criteria
I have been diagnosed with idiopathic pulmonary fibrosis.
Treatment Details
The study tests if exercising one leg at a time can improve endurance more than the usual two-leg cycling for people with IPF. The idea is to reduce breathing demand during exercise by working fewer muscles simultaneously.
2Treatment groups
Experimental Treatment
Active Control
Group I: intervention -1-leg cycle trainingExperimental Treatment1 Intervention
Primary aerobic training component one-legged, partitioned, cycle training. A progressive approach to combined intensity and duration will be taken. A cycle starting with intermittent high intensity one-legged exercise progressing to continuous duration of the target duration of 15 min for each leg and then restarting the cycle at a higher intensity.
Group II: usual care - 2-leg cycle trainingActive Control1 Intervention
Primary aerobic training component conventional two-legged cycle training. A progressive approach to combined intensity and duration will be taken. A cycle starting with intermittent high intensity exercise progressing to continuous duration of 30 min and then restarting the cycle at a higher intensity.
Find a clinic near you
Research locations nearbySelect from list below to view details:
West Park Healthcare CentreToronto, Canada
Loading ...
Who is running the clinical trial?
West Park Healthcare CentreLead Sponsor
References
Effects of one-legged exercise training of patients with COPD. [2008]Most patients with severe COPD are limited by dyspnea and are obliged to exercise at low intensity. Even those undergoing training do not usually have increased peak oxygen uptake (Vo2). One-legged exercise, at half the load of two-legged exercise, places the same metabolic demands on the targeted muscles but reduces the ventilatory load, enabling patients to increase work capacity. The purpose of this study was to determine whether one-legged exercise training would improve aerobic capacity compared with two-legged training in stable patients with COPD.
Aerobic high intensity one and two legs interval cycling in chronic obstructive pulmonary disease: the sum of the parts is greater than the whole. [2021]The purpose of this study was to investigate whether individual leg cycling could produce higher whole body peak oxygen uptake (VO(2peak)) than two legs cycling during aerobic high intensity interval training in chronic obstructive pulmonary disease (COPD) patients. Nineteen patients trained in 24 supervised cycling sessions either by one leg training (OLT) (n = 12) or by two legs training (TLT) (n = 7) at 4 x 4 min intervals at 85-95% of peak heart rate. Whole body VO(2peak) and peak work rate increased significantly by 12 and 23% in the OLT, and by 6 and 12% in the TLT from pre- to post-training, respectively, and were significantly greater in the OLT than the TLT (P
Aerobic high intensity one-legged interval cycling improves peak oxygen uptake in chronic obstructive pulmonary disease patients; no additional effect from hyperoxia. [2009]The aim of the present study was to investigate whether hyperoxic aerobic high intensity one-legged interval cycling improves peak oxygen uptake (V O (2peak)) compared to normoxic training in patients with severe chronic obstructive pulmonary disease, and to evaluate the acute effect of hyperoxia during one- and two-legged peak exercise testing. Twelve COPD patients were recruited to perform 3 training sessions per week for 8 weeks in hyperoxia (n=7) or normoxia (n=5). Each leg was trained 4x4 min at 85-95% of the one-legged peak heart rate. One-legged V O (2peak) increased in the hyperoxia and normoxia training groups by 24 and 15% (16.1(13.2)-20.0(11.3) and 17.4(15.1)-20.0(6.7) mL.kg (-1).min (-1)) respectively. The corresponding increases in V O (2peak) during two-legged testing were 14% in both groups (20.1(11.5)-22.9(10.6) and 18.8(8.5)-21.4(7.3) mL.kg (-1).min (-1)). There were no differences between groups from pre- to post-training. Nor were there any differences between acute hyperoxia and normoxia at the pre- or post-peak exercise test. One-legged aerobic high intensity interval cycling significantly increases V O (2peak) in COPD patients. However, breathing supplemental oxygen during training or testing does not appear to improve V O (2peak) above the level attained by breathing ambient air.
Assessing the effect of high-repetitive single limb exercises (HRSLE) on exercise capacity and quality of life in patients with chronic obstructive pulmonary disease (COPD): study protocol for randomized controlled trial. [2022]Single-limb knee extension exercises have been found to be effective at improving lower extremity exercise capacity in patients with chronic obstructive pulmonary disease (COPD). Since the positive local physiological effects of exercise training only occur in the engaged muscle(s), should upper extremity muscles also be included to determine the effect of single limb exercises in COPD patients.
One-Legged Cycle Training for Chronic Obstructive Pulmonary Disease. A Pragmatic Study of Implementation to Pulmonary Rehabilitation. [2015]In patients with chronic obstructive pulmonary disease (COPD), partitioned exercise training using one-legged cycling leads to greater improvements in peak oxygen uptake than conventional two-legged cycling.
COPD: benefits of exercise training. [2016]In patients with stable, moderate or severe chronic obstructive pulmonary disease (COPD), general exercise training, including limb exercises, provides sustained improvement in various quality of life domains, compared with care without pulmonary rehabilitation. After a COPD exacerbation, exercise training appears to reduce the risk of hospitalisation in the following months by at least half. Few studies have evaluated the adverse effects of exercise training in COPD, but based on the data available in 2015, its harm-benefit balance appears favourable.
[Exercise training can improve dyspnea among persons with COPD and IPF]. [2022]This article presents updated data regarding exercise training among persons with chronic obstructive pulmonary disease (COPD) and idiopathic pulmonary fibrosis (IPF). Persons with stable COPD and IPF can improve quality of life, physical capacity and dyspnea after a period of exercise training. Persons with COPD exacerbation can improve quality of life and physical capacity, and decrease hospital re-admissions, if they start physical activity directly after the exacerbation. Persons with stable COPD and IPF should be recommended aerobic and muscle strengthening training. For those with balance impairments balance training is also recommended. Persons with COPD exacerbation should be recommended activities of daily living (ADL) followed by muscle strengthening training and then aerobic training in the early recovery phase. Diagnosis-specific advice includes individually tailored exercise training, physical activity recommendations, breathing techniques, and that oxygen saturation during exercise should be ≥88 percent in COPD and ≥85 percent in IPF.