One-Legged vs Two-Legged Cycle Training for Idiopathic Pulmonary Fibrosis
Trial Summary
What is the purpose of this trial?
Idiopathic pulmonary fibrosis (IPF) is a lung disease that limits the ability to breathe enough for a good workout. One way to improve the exercise training is to reduce the number of muscles being trained together. By training one leg at a time, the patient does not have to breathe as much allowing each leg a better workout. Our groundwork suggests it may work in patients with IPF. This study will help decide whether one-legged exercise training is better at improving a patient's exercise endurance compared to the usual way of exercising with both legs at the same time.
Will I have to stop taking my current medications?
The trial information does not specify whether you need to stop taking your current medications.
What data supports the effectiveness of one-legged cycle training as a treatment for idiopathic pulmonary fibrosis?
Research on patients with chronic obstructive pulmonary disease (COPD) shows that one-legged cycle training can lead to greater improvements in peak oxygen uptake and work capacity compared to two-legged cycling. This suggests that similar benefits might be seen in patients with idiopathic pulmonary fibrosis, as exercise training has been shown to improve quality of life and physical capacity in both conditions.12345
Is one-legged or two-legged cycle training safe for humans?
Exercise training, including one-legged and two-legged cycling, appears to be safe for people with chronic obstructive pulmonary disease (COPD), with a favorable balance of benefits over risks. Although specific safety data for idiopathic pulmonary fibrosis (IPF) is not detailed, exercise training is generally recommended for improving quality of life and physical capacity in both COPD and IPF.12456
How does one-legged cycle training differ from other treatments for idiopathic pulmonary fibrosis?
Research Team
Roger Goldstein, MD, FRCPC
Principal Investigator
West Park Healthcare Centre
Eligibility Criteria
This trial is for stable patients with confirmed idiopathic pulmonary fibrosis who are enrolled in a pulmonary rehab program. It's not suitable for those who've had a recent exacerbation, finished rehab within the last 6 months, or have other health issues that could make rehab unsafe.Inclusion Criteria
Exclusion Criteria
Trial Timeline
Screening
Participants are screened for eligibility to participate in the trial
Treatment
Participants undergo partitioned aerobic exercise training with either one-legged or two-legged cycle training for 8 weeks
Follow-up
Participants are monitored for safety and effectiveness after treatment
Treatment Details
Interventions
- 1-leg cycle training (Behavioural Intervention)
- 2-leg cycle training (Behavioural Intervention)
Find a Clinic Near You
Who Is Running the Clinical Trial?
West Park Healthcare Centre
Lead Sponsor