Trial Summary
What is the purpose of this trial?To learn if using MRI (magnetic resonance imaging) to guide radiation therapy can help to control central lung cancer. The results of the MRI-guided radiation therapy will be compared to conventional radiation therapy (guided by CT scans) during this study.
Eligibility Criteria
This trial is for adults with central lung tumors close to critical structures who can sign consent. It's for those needing more than 10-15 radiation sessions if using CT-based therapy, and includes primary or metastatic lung cancer patients. Pregnant women, individuals unable to undergo MRI due to claustrophobia or metal implants, and those not using contraception are excluded.Treatment Details
The study tests Stereotactic MRI-guided Adaptive Radiation Therapy (SMART) against conventional CT-guided therapy in controlling central lung cancer. The goal is to see if MRI guidance improves treatment precision and effectiveness compared to the usual method.
2Treatment groups
Experimental Treatment
Group I: Stage II (Stereotactic MRI-guided adaptive radiotherapy-SMART)Experimental Treatment1 Intervention
Participants will receive treatment with the investigational MRI-guided radiation therapy.
Group II: Stage I-(Simulated Online Adaptive Planning)Experimental Treatment1 Intervention
Participants will receive treatment with the conventional CT-based radiation therapy and receive additional MRI scans.
Find a clinic near you
Research locations nearbySelect from list below to view details:
M. D. Anderson Cancer CenterHouston, TX
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Who is running the clinical trial?
M.D. Anderson Cancer CenterLead Sponsor