SMART for Lung Cancer

Recruiting in Palo Alto (17 mi)

Saumil Gandhi | MD Anderson Cancer Center

Overseen bySaumil Gandhi, MD

Age: 18+

Sex: Any

Travel: May Be Covered

Time Reimbursement: Varies

Trial Phase: Academic

Waitlist Available

Sponsor: M.D. Anderson Cancer Center

No Placebo Group

Trial Summary

What is the purpose of this trial?

To learn if using MRI (magnetic resonance imaging) to guide radiation therapy can help to control central lung cancer. The results of the MRI-guided radiation therapy will be compared to conventional radiation therapy (guided by CT scans) during this study.

Research Team

Saumil Gandhi, MD

Principal Investigator

M.D. Anderson Cancer Center

Eligibility Criteria

This trial is for adults with central lung tumors close to critical structures who can sign consent. It's for those needing more than 10-15 radiation sessions if using CT-based therapy, and includes primary or metastatic lung cancer patients. Pregnant women, individuals unable to undergo MRI due to claustrophobia or metal implants, and those not using contraception are excluded.

Inclusion Criteria

Ability to understand and the willingness to sign a written informed consent

The tumor is located very close to important structures in the chest.

Age ≥ 18 years

See 2 more

Exclusion Criteria

You can't handle being in a tight space for an MRI scan, for example, if you have claustrophobia.

Contraindications to MR imaging (e.g. implanted metallic prostheses, defibrillators, stimulators, pacemakers, or neurotransmitters) per institutional policy on management of patients with internal and external medical devices

Women who are pregnant. Women of childbearing potential and men must agree to use adequate contraception (hormonal or barrier method of birth control, abstinence) prior to study entry. Should a woman become pregnant or suspect she is pregnant while participating in this study, she must inform her treating physician immediately.

Treatment Details

Interventions

Stereotactic MRI-guided adaptive radiotherapy-SMART (Radiation Therapy)

Trial OverviewThe study tests Stereotactic MRI-guided Adaptive Radiation Therapy (SMART) against conventional CT-guided therapy in controlling central lung cancer. The goal is to see if MRI guidance improves treatment precision and effectiveness compared to the usual method.

Participant Groups

2Treatment groups

Experimental Treatment

Group I: Stage II (Stereotactic MRI-guided adaptive radiotherapy-SMART)Experimental Treatment1 Intervention

Participants will receive treatment with the investigational MRI-guided radiation therapy.

Group II: Stage I-(Simulated Online Adaptive Planning)Experimental Treatment1 Intervention

Participants will receive treatment with the conventional CT-based radiation therapy and receive additional MRI scans.