Exercise Intervention for Age-Related Macular Degeneration

N/A

Recruiting

Led By Joe R. Nocera, PhD

Research Sponsored by VA Office of Research and Development

Eligibility Criteria Checklist

Specific guidelines that determine who can or cannot participate in a clinical trial

Must have

Be older than 65 years old

Timeline

Screening 3 weeks

Treatment Varies

Follow Up change from best corrected visual acuity at 6 months

Awards & highlights

No Placebo-Only Group

Summary

This trial aims to use exercise to help Veterans with AMD improve physical, cognitive, and visual outcomes. There are no cures or treatments, so this could benefit the aging Veteran population.

Who is the study for?

This trial is for US Veterans aged 65-89 with intermediate stage Age-Related Macular Degeneration (AMD) in at least one eye. They must be cognitively intact, free from major diseases affecting exercise ability or brain function, not have severe psychiatric disorders or substance abuse issues, and must have stable internet access.

What is being tested?

The study tests the effects of a 6-month online group spin cycling program on physical, cognitive, and visual outcomes in Veterans with AMD. It aims to see if this aerobic exercise can improve vision loss caused by AMD as well as enhance overall quality of life.

What are the potential side effects?

While specific side effects are not listed for spinning exercises, participants may experience general exercise-related discomforts such as muscle soreness or fatigue. The risk of injury could also increase due to balance issues related to age and potential vision impairment.

Timeline

Screening ~ 3 weeks3 visits

Treatment ~ Varies

Follow Up ~ change from baseline contrast sensitivity at 6 months

Screening ~ 3 weeks

Treatment ~ Varies

Follow Up ~change from baseline contrast sensitivity at 6 months

This trial's timeline: 3 weeks for screening, Varies for treatment, and change from baseline contrast sensitivity at 6 months for reporting.

Treatment Details

Study Objectives

Study objectives can provide a clearer picture of what you can expect from a treatment.

Primary study objectives

Dark adaptometry

contrast sensitivity

Secondary study objectives

Best Corrected Visual Acuity

Awards & Highlights

No Placebo-Only Group

All patients enrolled in this study will receive some form of active treatment.

Trial Design

2Treatment groups

Experimental Treatment

Active Control

Group I: SPINExperimental Treatment1 Intervention

Exercise 3 times a week on a stationary ergometer @ 50-80% of maximal heart rate reserve for 20 minutes to 45 minutes per session

Group II: Non-aerobic, stretching/balance intervention ControlActive Control1 Intervention

For this arm of the intervention, randomized participants followed the same guidelines as the SPIN group but did not partake in aerobic exercise. To equalize contact/monitoring of the groups this group met for the same total duration time as the SPIN group; however, instead of aerobic exercise, progressive whole body stretching and toning exercises

Do I qualify?Apply below to find out