Acute Intermittent Hypoxia for Multiple Sclerosis

Recruiting in Palo Alto (17 mi)

Age: 18+

Sex: Any

Travel: May Be Covered

Time Reimbursement: Varies

Trial Phase: Academic

Waitlist Available

Sponsor: Shirley Ryan AbilityLab

No Placebo Group

Trial Summary

What is the purpose of this trial?

This study seeks to explore changes in the neural pathways and arm function following a breathing intervention in the multiple sclerosis (MS) population. The breathing intervention, known as Acute Intermittent Hypoxia (AIH), involves breathing brief bouts of low levels of oxygen. Research has found AIH to be a safe and effective intervention resulting in increased ankle strength in people with MS. Here, the study examines arm and hand function before and after AIH. In order to better understand the brain and spinal cord response to AIH, the investigators will measure muscle response, and signals sent from the brain to the arm muscles before and after AIH.

Research Team

Eligibility Criteria

This trial is for individuals with Multiple Sclerosis (MS) who are interested in a breathing intervention that may improve arm and hand function. Specific eligibility criteria details were not provided, so participants should inquire further to determine if they qualify.

Inclusion Criteria

I have been free from cancer relapse for at least 6 months.

I was diagnosed with relapsing-remitting MS more than 5 years ago.

I can walk with assistance.

See 3 more

Exclusion Criteria

Modified Ashworth Scale score >3 on elbow joint

Pregnancy as confirmed by urine test

I have a condition that affects the use of my arms.

See 4 more

Treatment Details

Interventions

Acute Intermittent Hypoxia (Behavioural Intervention)

Trial OverviewThe study tests the effects of Acute Intermittent Hypoxia (AIH), which involves breathing low oxygen levels briefly, on neural pathways and arm function in MS patients. It compares AIH with a sham procedure to assess changes in muscle response and brain signals.

Participant Groups

2Treatment groups

Experimental Treatment

Group I: Sham FirstExperimental Treatment2 Interventions

Participants in the this arm will undergo 2 sessions of Sham AIH each separated by a 1-week washout period. 1 week later, participants will undergo 2 sessions of AIH also separated by a 1-week washout period.

Group II: AIH firstExperimental Treatment2 Interventions

Participants in the first arm will undergo 2 sessions of AIH each separated by a 1-week washout period. 1 week later, participants will undergo 2 sessions of Sham AIH also separated by a 1-week washout period.