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Exercise Intensity for Myasthenia Gravis (MG-Ex Trial)

N/A
Recruiting
Research Sponsored by HealthPartners Institute
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Age 18-80
Diagnosis of generalized MG
Must not have
Significant cognitive impairment of any etiology that would impact study participation
History of heart failure, chronic lung disease, angina or any other condition that causes unreasonable shortness of breath on exertion
Timeline
Screening 3 weeks
Treatment Varies
Follow Up 12 weeks
Awards & highlights

Summary

"This trial aims to compare the effects of light and moderate intensity exercise on health outcomes in individuals with neurological disorders or injuries. Participants will join a specialized exercise program and attend group sessions three times a week for

Who is the study for?
This trial is for individuals with Myasthenia Gravis, a condition causing muscle weakness. It's designed to test whether different exercise intensities affect their health outcomes. Participants will join the NeuroWell program and must be able to exercise three times a week for 12 weeks.
What is being tested?
The study compares light vs. moderate intensity exercises in managing Myasthenia Gravis symptoms. A total of 20 participants will be randomly assigned to one of two groups, exercising under supervision by Certified Exercise Physiologists at the Neuroscience Center.
What are the potential side effects?
Since this trial involves physical exercise, potential side effects may include muscle soreness, fatigue, or exacerbation of symptoms related to Myasthenia Gravis depending on individual tolerance and response to activity.

Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below
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I am between 18 and 80 years old.
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I have been diagnosed with generalized myasthenia gravis.

Exclusion Criteria

You may be eligible for the trial if you check “No” for criteria below:
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I do not have any cognitive issues that would affect my participation in the study.
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I have a condition like heart failure or lung disease that makes me unusually short of breath.
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I am not pregnant and do not plan to become pregnant during the study.

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~12 weeks
This trial's timeline: 3 weeks for screening, Varies for treatment, and 12 weeks for reporting.

Treatment Details

Study Objectives

Study objectives can provide a clearer picture of what you can expect from a treatment.
Primary study objectives
Cardiovascular Test - 6-minute walk test
Functional strength - Sit to stand test
Strength Test - 1-RM Lower Limb
+1 more
Secondary study objectives
Fatigue - Fatigue Severity Scale
MG-Activities of Daily Living (ADL)
MG-Quality of life (QOL)

Trial Design

2Treatment groups
Experimental Treatment
Group I: Moderate intensity ExerciseExperimental Treatment1 Intervention
Aerobic intensity levels: HRR 40-59%, 12-13 Borg RPE Strength intensity levels: %1RM 60-80%, OMNI RPE 5-6
Group II: Light intensity ExerciseExperimental Treatment1 Intervention
Aerobic intensity levels: Heart rate reserve (HRR) 30-39%, 9-11 Borg Rate of Perceived Exertion (RPE) Strength intensity levels: %One Repetition Max (1RM) 40-50%, OMNI RPE 1-4
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
Moderate Intensity Exercise
2019
Completed Phase 4
~150

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Who is running the clinical trial?

HealthPartners InstituteLead Sponsor
191 Previous Clinical Trials
3,721,637 Total Patients Enrolled
1 Trials studying Myasthenia Gravis
24 Patients Enrolled for Myasthenia Gravis
~13 spots leftby Jun 2025
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