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Exercise and Bracing for Muscle Atrophy (HYPAT Trial)

N/A

Waitlist Available

Research Sponsored by McMaster University

Eligibility Criteria Checklist

Specific guidelines that determine who can or cannot participate in a clinical trial

Must have

Healthy males, between the ages of 18 and 30 y

Be between 18 and 65 years old

Must not have

A (family) history of thrombosis

A history of neuromuscular disorders or muscle/bone wasting diseases

Timeline

Screening 3 weeks

Treatment Varies

Follow Up baseline, day 5, day 9 and day 14 (post)

Awards & highlights

No Placebo-Only Group

Summary

This trial looks at the effect of immobilization and resistance exercise on muscle mass and strength.

Who is the study for?

Healthy males aged 18-30 with a BMI of 18.5 to 30 can join this study. They must be able to consent and not have muscle or bone diseases, serious illnesses, uncontrolled hypertension, diabetes, or take meds affecting protein metabolism. Non-smokers who don't drink excessively or exercise more than twice a week are eligible.

What is being tested?

The trial is testing the effects of knee bracing and unilateral resistance exercise training on muscle size changes due to loading (exercise) and unloading (immobilization). It aims to understand individual molecular responses over an acute period using advanced proteomics techniques.

What are the potential side effects?

Potential side effects may include discomfort from wearing the knee brace and typical exercise-related issues such as muscle soreness or strain from resistance training.

Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below

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I am a healthy male aged between 18 and 30.

Exclusion Criteria

You may be eligible for the trial if you check “No” for criteria below:

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I or someone in my family has had blood clots.

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I have a history of muscle or nerve disorders.

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I have a history of bleeding disorders or I am on blood thinning medication.

Timeline

Screening ~ 3 weeks3 visits

Treatment ~ Varies

Follow Up ~ baseline, day 5, day 9 and day 14 (post)

Screening ~ 3 weeks

Treatment ~ Varies

Follow Up ~baseline, day 5, day 9 and day 14 (post)

This trial's timeline: 3 weeks for screening, Varies for treatment, and baseline, day 5, day 9 and day 14 (post) for reporting.

Treatment Details

Study Objectives

Study objectives can provide a clearer picture of what you can expect from a treatment.

Primary study objectives

Change in Dynamic Proteomics

Change in Integrated Rates of Muscle Protein Synthesis

Secondary study objectives

Change in Lean Mass Using Dual X-Ray Absorptiometry

Change in Muscle Cross-Sectional Area using Ultrasonography

Change in Muscle Strength using an Isokinetic Dynamometer

Awards & Highlights

No Placebo-Only Group

All patients enrolled in this study will receive some form of active treatment.

Trial Design

2Treatment groups

Experimental Treatment

Group I: Unilateral Resistance ExerciseExperimental Treatment1 Intervention

One leg will undergo 4 sessions of unilateral resistance exercise, over the course of 8 days. Specifically, participants will be asked to perform leg press and leg extension.

Group II: Unilateral ImmobilizationExperimental Treatment1 Intervention

One leg will undergo 14 days of single-leg immobilization, by means of a removable knee brace.

0 / 4Eligibility criteria met