CMR Imaging Techniques for Heart Disease
(Myomapping Trial)
Recruiting in Palo Alto (17 mi)
Age: 18+
Sex: Any
Travel: May Be Covered
Time Reimbursement: Varies
Trial Phase: Academic
Recruiting
Sponsor: Medical University of South Carolina
Disqualifiers: Implanted device, Acute psychiatric, Substance abuse, others
No Placebo Group
Approved in 6 Jurisdictions
Trial Summary
What is the purpose of this trial?The overall goal of this project is to evaluate the clinical potential of fast quantitative myocardial tissue characterization using recently emerged Cardiac Magnetic Resonance Imaging (CMR) techniques to aid the diagnosis, treatment, and follow up of patients with myocardial diseases, such as ischemic heart disease, cardiomyopathies, and myocarditis.
Will I have to stop taking my current medications?
The trial information does not specify whether you need to stop taking your current medications. It's best to discuss this with the trial coordinators or your doctor.
What data supports the effectiveness of the treatment Cardiac Magnetic Resonance (CMR) imaging techniques for heart disease?
CMR imaging is a powerful tool for diagnosing and monitoring heart diseases because it provides detailed images of the heart without using radiation. It is especially useful for evaluating conditions like coronary artery disease and cardiomyopathies, offering important information that other imaging methods cannot provide.
12345Is CMR imaging safe for humans?
CMR imaging is generally considered safe as it is non-invasive and does not use radiation. However, there are some safety considerations, such as the presence of metal or electronic devices in the body, and potential discomfort from claustrophobia or the need to hold your breath during the procedure.
36789How does CMR imaging differ from other treatments for heart disease?
CMR imaging is unique because it provides a noninvasive way to assess the heart's structure and function, offering detailed tissue characterization and the ability to evaluate heart disease without the need for invasive procedures. Unlike other treatments, it can provide comprehensive diagnostic and prognostic information, making it a valuable tool for monitoring heart disease over time.
1241011Eligibility Criteria
This trial is for adults aged 18-90 with suspected or diagnosed heart conditions like ischemic heart disease, hypertrophic cardiomyopathy, infiltrative cardiomyopathy, or myocarditis. They must be referred for a CMR scan and can't participate if they have metal implants, acute psychiatric disorders, substance abuse issues, allergies to MRI contrast agents, are in an unstable condition or won't follow the study rules.Inclusion Criteria
I have or might have a heart condition such as blocked arteries, thickened heart muscle, a disease causing heart tissue buildup, or inflammation of the heart muscle.
I am between 18 and 90 years old.
You must have been referred for a needed heart imaging test.
Exclusion Criteria
Subject has previously entered this study.
Subject has an allergy against MRI contrast agents.
Subject is in acute unstable condition.
+4 more
Trial Timeline
Screening
Participants are screened for eligibility to participate in the trial
2-4 weeks
Imaging
Participants undergo fast quantitative myocardial tissue characterization using Cardiac Magnetic Resonance Imaging (CMR) techniques
1 day
1 visit (in-person)
Follow-up
Participants are monitored for safety and effectiveness after imaging
4 weeks
Participant Groups
The trial is testing advanced Cardiac Magnetic Resonance Imaging (CMR) techniques to better diagnose and monitor various heart diseases. It aims to see how well these new fast quantitative imaging methods work compared to traditional ones.
1Treatment groups
Experimental Treatment
Group I: Additional 5 minute research MR scan of heart.Experimental Treatment1 Intervention
The purpose of this is to evaluate new, faster MR scans
Find a Clinic Near You
Research Locations NearbySelect from list below to view details:
Medical University of South CarolinaCharleston, SC
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Who Is Running the Clinical Trial?
Medical University of South CarolinaLead Sponsor
References
Advances in Cardiovascular MRI for Diagnostics: Applications in Coronary Artery Disease and Cardiomyopathies. [2021]BACKGROUND: Cardiac magnetic resonance (CMR) imaging has emerged as an important cardiac imaging technique for the evaluation of multiple cardiac pathologies. OBJECTIVE/METHOD: The goal of this review is to describe recent advances in techniques which have extended the potential applications of CMR. The focus will be on the clinical applications of CMR for the evaluation of coronary artery disease and heart failure/cardiomyopathies which are major causes of morbidity and mortality worldwide. CONCLUSION: CMR provides unique tissue characterization which is not available from other imaging modalities and has demonstrated important diagnostic and prognostic information in many forms of heart disease.
Cardiac MRI: technical basis. [2020]Cardiac magnetic resonance (CMR) imaging is an effective method for noninvasively imaging the heart which in the last two decades impressively enhanced spatial and temporal resolution and imaging speed, broadening its spectrum of applications in cardiovascular disease. CMR imaging techniques are designed to noninvasively assess cardiovascular morphology, ventricular function, myocardial perfusion, tissue characterization, flow quantification and coronary artery disease. These intrinsic features yield CMR suitable for diagnosis, follow-up and longitudinal monitoring after treatment of cardiovascular diseases. The aim of this paper is to review the technical basis of CMR, from cardiac imaging planes to cardiac imaging sequences.
Introduction to Cardiovascular Magnetic Resonance: Technical Principles and Clinical Applications. [2020]Cardiovascular magnetic resonance (CMR) is a set of magnetic resonance imaging (MRI) techniques designed to assess cardiovascular morphology, ventricular function, myocardial perfusion, tissue characterization, flow quantification and coronary artery disease. Since MRI is a non-invasive tool and free of radiation, it is suitable for longitudinal monitoring of treatment effect and follow-up of disease progress. Compared to MRI of other body parts, CMR faces specific challenges from cardiac and respiratory motion. Therefore, CMR requires synchronous cardiac and respiratory gating or breath-holding techniques to overcome motion artifacts. This article will review the basic principles of MRI and introduce the CMR techniques that can be optimized for enhanced clinical assessment.
The Multi-Faceted Utility of Cardiovascular Magnetic Resonance Imaging: Editorial on Special Issue "Advances in Cardiovascular Magnetic Resonance". [2023]Cardiovascular magnetic resonance (CMR) imaging has emerged as a versatile tool for evaluating and managing a variety of cardiovascular diseases [...].
Appropriate use criteria for cardiovascular MRI: SIC - SIRM position paper Part 2 (myocarditis, pericardial disease, cardiomyopathies and valvular heart disease). [2023]Cardiovascular magnetic resonance (CMR) has emerged as an accurate diagnostic technique for the evaluation of patients with cardiac disease in the majority of clinical settings, thanks to an established additional diagnostic and prognostic value. This document has been developed by a joined group of experts of the Italian Society of Cardiology (SIC) and Italian Society of Radiology (SIRM) to provide a summary about the current state of technology and clinical applications of CMR, to improve the clinical diagnostic pathways and to promote its inclusion in clinical practice. The writing committee consisted of members and experts of both societies in order to develop a more integrated approach in the field of cardiac imaging. This section 2 will cover myocarditis, pericardial disease, cardiomyopathies and valvular heart disease.
Role of cardiovascular magnetic resonance in acute and chronic ischemic heart disease. [2018]Cardiovascular magnetic resonance (CMR) is a multi-parametric, multi-planar, non-invasive imaging technique, which allows accurate determination of biventricular function and precise myocardial tissue characterization in a one-stop-shop technique, free from the use of ionizing radiations. Though CMR has been increasingly applied over the last two decades in every-day clinical practice, its widest application has been in the assessment of ischemic cardiomyopathy.
Risk factors for adverse events during cardiovascular magnetic resonance in congenital heart disease. [2013]To assess the incidence and severity of adverse events (AE) associated with cardiovascular magnetic resonance (CMR) in a large cohort of patients with congenital heart disease and to identify independent risk factors for their occurrence.
Current variables, definitions and endpoints of the European cardiovascular magnetic resonance registry. [2021]Cardiovascular magnetic resonance (CMR) is increasingly used in daily clinical practice. However, little is known about its clinical utility such as image quality, safety and impact on patient management. In addition, there is limited information about the potential of CMR to acquire prognostic information.
Cardiovascular magnetic resonance: What clinicians should know about safety and contraindications. [2021]Cardiovascular magnetic resonance (MR) is a multiparametric, non-ionizing, non-invasive imaging technique, which represents the imaging gold standard to study cardiac anatomy, function and tissue characterization. Faced with a wide range of clinical application, in this review we aim to provide a comprehensive guide for clinicians about MR safety, contraindications and image quality. Starting from the physical interactions of the static magnetic fields, gradients and radiofrequencies with the human body, we will describe the most common metal and electronic devices which are allowed (MR-safe), allowed under limited conditions (MR-conditional) or contraindicated (MR-unsafe). Moreover, some conditions potentially affecting image quality and patient comfort will be mentioned, including arrhythmias, claustrophobia, and poor breath-hold capacity. Finally, we will discuss the pharmacodynamics and pharmacokinetics of current gadolinium-based contrast agents, their contraindications and their potential acute and chronic adverse effects, as well as the safety issue concerning the use of vasodilating/inotropic agents in stress cardiac MR.
Current state of the art cardiovascular MR imaging techniques for assessment of ischemic heart disease. [2022]Cardiac magnetic resonance (CMR) imaging is increasingly being used to evaluate patients with known or suspected ischemic heart disease, because of its ability to acquire images in any orientation and the wide variety of sequences available to characterize normal and abnormal structure and function. Substantial improvements have been made in the hardware and software used to perform CMR, resulting in better and more consistent image quality. There has been a greater emphasis recently in developing and validating quantitative CMR techniques. This article reviews advances in CMR techniques for assessing cardiac function, myocardial perfusion, late gadolinium enhancement, and tissue characterization with T1 and T2 mapping sequences.
Cardiac magnetic resonance imaging: current status and future directions. [2013]Cardiac MRI (CMR) provides a comprehensive evaluation of cardiac function and anatomy, as well as myocardial tissue characterization and perfusion. New data show the potential for CMR to analyze left ventricular diastolic function, coronary plaque and myocardial oxygen levels. A growing body of animal and clinical data on molecular imaging, hybrid imaging and interventional CMR holds promise for more widespread clinical application. Technological advances in body coils, 3-T systems, imaging sequences and novel applications such as T1 mapping will expand the application and quality of CMR.