Motion-Corrected Cone-Beam CT for Lung Cancer

Recruiting in Palo Alto (17 mi)

+3 other locations

Overseen byZhang Peng, PhD

Age: 18+

Sex: Any

Travel: May Be Covered

Time Reimbursement: Varies

Trial Phase: Academic

Waitlist Available

Sponsor: Memorial Sloan Kettering Cancer Center

No Placebo Group

Trial Summary

What is the purpose of this trial?

The first purpose of this study is to test a new computer program that reduces the blurring in the cone-beam CT scan and helps the doctor to better locate the tumor. The investigators want to find out what effects, good and/or bad, that this has on the patient and the way we treat the cancer in the lungs. The second purpose of this study is to test how well this computer program tracks markers in the images, compared to using radio signals to follow the markers.

Eligibility Criteria

This trial is for adults over 18 with confirmed lung malignancies suitable for radiation therapy, who are planning to undergo such treatment. They must have a visible part of the tumor on CT scans and be in relatively good health (Karnofsky Performance Status ≥ 60%). They should be able to have small markers placed in their lungs via bronchoscopy.

Inclusion Criteria

I can care for myself but may need occasional help.

I am 18 years old or older.

I can have a procedure to place tracking devices in my lungs, as shown by a recent CT scan.

See 3 more

Exclusion Criteria

I cannot safely have a bronchoscopy according to hospital rules.

I currently have a serious infection.

I cannot safely undergo anesthesia or sedation.

See 9 more

Treatment Details

Interventions

Bronchoscopic Implantation (Procedure)
Cone-Beam CT-Guided (Device)
Stereotactic Body Radiation Treatments (Radiation Therapy)

Trial OverviewThe study is testing a new computer program that aims to reduce blurring on cone-beam CT scans used during lung cancer treatments. It will compare how well this program locates tumors against another method using radio signals to track implanted markers during stereotactic body radiation treatments.

Participant Groups

1Treatment groups

Experimental Treatment

Group I: Patients with lung cancerExperimental Treatment3 Interventions

Physician evaluation of patient setup accuracy will be performed using all available images and adjustments will be made as per standard practice. In addition, a respiration motion-corrected CBCT (daily for SBRT, weekly for standard fractionation) will be used to confirm the accuracy of Calypso-based setup. Patients will return for follow up at 3,6, 9, 12, 15, 18, 21 and 24 months (+/- 4 weeks) following completion of radiation therapy. The following assessments will be performed at these visits: history and physical exam, diagnostic CT chest, and toxicity assessment.