Reflex Training for Neuropathic Pain in Spinal Cord Injury
Trial Summary
What is the purpose of this trial?
The purpose of the second part of the study is to examine the effect of reflex training in the leg to decrease neuropathic pain. For this, the researchers are recruiting 15 individuals with neuropathic pain due to spinal cord injury to participate in the reflex training procedure. The study involves approximately 50 visits with a total study duration of about 6.5 months (3 months for baseline and training phases followed by 1 month and 3 month follow-up visits).
Will I have to stop taking my current medications?
The trial requires that you keep taking your current medications without any changes for at least 3 months. If you are on anti-spasticity medication, you can continue using it as usual.
What data supports the effectiveness of the treatment Operant Conditioning of Cutaneous Reflexes for neuropathic pain in spinal cord injury?
Research on operant conditioning of spinal reflexes shows promising results in both animals and humans, indicating that this approach can help modify reflex behaviors through brain and spinal cord plasticity. This suggests potential benefits for managing neuropathic pain in spinal cord injury patients.12345
Is reflex training for neuropathic pain in spinal cord injury safe?
Research on reflex training, also known as operant conditioning of spinal reflexes, has been conducted in animals and humans, showing promising results without significant safety concerns. Studies have demonstrated that this method can safely modify reflexes in people with spinal cord injuries, suggesting it is generally safe for human use.46789
How does the Reflex Training Procedure treatment differ from other treatments for neuropathic pain in spinal cord injury?
The Reflex Training Procedure is unique because it uses operant conditioning to modify spinal reflexes, promoting plasticity (the ability to change and adapt) in the nervous system, which can improve motor function and potentially reduce pain. Unlike traditional treatments that may rely on medication, this approach focuses on retraining the body's reflex pathways to enhance recovery.18101112
Eligibility Criteria
This trial is for individuals with neuropathic pain in the lower leg due to spinal cord injury. They must be stable over a year post-injury, able to stand for at least 3 minutes, and on steady medication for 3 months. Excluded are those with motoneuron injuries, heart conditions, cognitive impairments or complete lack of sensation around the foot.Inclusion Criteria
Exclusion Criteria
Trial Timeline
Screening
Participants are screened for eligibility to participate in the trial
Baseline
Participants undergo baseline assessments including cutaneous reflex examination and sensation assessment
Conditioning
Participants complete 30 conditioning sessions to alter cutaneous reflexes and reduce neuropathic pain
Follow-up
Participants are monitored for safety and effectiveness after treatment
Treatment Details
Interventions
- Operant Conditioning of Cutaneous Reflexes (Behavioral Intervention)