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Exercise for Obesity

N/A
Recruiting
Led By Luke Olsen, PhD
Research Sponsored by Rockefeller University
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Being between the ages of 18-45
Free of metabolic or cardiovascular diseases
Must not have
Recent uncontrolled bruising
Unhealed fractures
Timeline
Screening 3 weeks
Treatment Varies
Follow Up 1 week pre-intervention, 1-hour following, 3-hours following
Awards & highlights
No Placebo-Only Group

Summary

This trial aims to understand how exercise affects the release of proteins in the body. Researchers will collect fat and blood samples before and after exercise to study the proteins released and how they interact with different tissues in

Who is the study for?
This trial is for moderately active individuals aged 18-45 who don't smoke and have no metabolic or cardiovascular diseases. Participants must pass the PARQ questionnaire, indicating they're safe to exercise, and should be exercising recreationally at least once but not more than three times a week.
What is being tested?
The study investigates how short-term exercise affects protein release into the bloodstream and their communication with fat tissue. It involves collecting blood and fat samples from participants before and after exercising to analyze proteins in blood and gene expression in fat tissue.
What are the potential side effects?
Since this trial involves moderate exercise as an intervention, typical side effects may include muscle soreness, fatigue, or minor injuries related to physical activity. No severe side effects are expected.

Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below
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I am between 18 and 45 years old.
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I do not have any heart or metabolic diseases.

Exclusion Criteria

You may be eligible for the trial if you check “No” for criteria below:
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I have been experiencing unexplained bruising.
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I have fractures that have not yet healed.
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I have had blood clots.
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I have recent damage to my muscles, bones, or joints that stops me from being active.
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I am currently taking hormone medications.
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I have had surgery on my limbs within the last year.
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I have felt chest pain when exercising.

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~1 week pre-intervention, 1-hour following, 3-hours following
This trial's timeline: 3 weeks for screening, Varies for treatment, and 1 week pre-intervention, 1-hour following, 3-hours following for reporting.

Treatment Details

Study Objectives

Study objectives can provide a clearer picture of what you can expect from a treatment.
Primary study objectives
Identification and quantification of exercise-induced proteins released into the blood through the use of proteomic analysis.
Secondary study objectives
Characterize changes in gene expression of the subcutaneous adipose tissue following exercise through the use of bulk RNA-sequencing.

Awards & Highlights

No Placebo-Only Group
All patients enrolled in this study will receive some form of active treatment.

Trial Design

1Treatment groups
Experimental Treatment
Group I: Secretome characterization and signaling to the adipose tissueExperimental Treatment1 Intervention
To identify possible exercise stimulated secreted proteins which signal to the adipose tissue, subcutaneous adipose and blood will be collected both before and at multiple timepoints following a VO2max test. Adipose will be collected from the abdominal subcutaneous region and blood will be collected from the arm. Blood will be analyzed for change in protein abundance and adipose will be analyzed for change in gene expression.

Find a Location

Who is running the clinical trial?

Hospital for Special Surgery, New YorkOTHER
250 Previous Clinical Trials
61,321 Total Patients Enrolled
1 Trials studying Obesity
300 Patients Enrolled for Obesity
Rockefeller UniversityLead Sponsor
160 Previous Clinical Trials
16,527 Total Patients Enrolled
19 Trials studying Obesity
442 Patients Enrolled for Obesity
Luke Olsen, PhDPrincipal InvestigatorThe Rockefeller University
~10 spots leftby Oct 2025
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