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GLP-1 Receptor Agonist
Strategies to Prevent Weight Regain for Obesity
N/A
Recruiting
Led By Kelseanna Hollis-Hansen, PhD, MPH
Research Sponsored by University of Texas Southwestern Medical Center
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial Must have
Be older than 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up 4-months
Summary
This trial tests if special meals or a weight management app can help adults keep off weight after stopping a weight-loss medication. The study focuses on those who have lost significant weight and stopped the medication. The meals make healthy eating easier, and the app provides support for maintaining good habits.
Who is the study for?
This trial is for adults who've lost over 10% of their body weight using GLP-1 receptor agonist medications, have stopped taking these meds within the last month, can consent to participate, and are fluent in English. It's not specified who cannot join.
What is being tested?
The study explores if usual care, medically tailored meals or a digital health program called Noom® can help maintain weight loss after stopping obesity medication (GLP-1s). The goal is to find cost-effective ways to keep the weight off long-term.
What are the potential side effects?
Since this trial tests non-medical interventions like special meals and a health app, side effects may be minimal compared to drug treatments. However, changes in diet or lifestyle adjustments could cause digestive changes or psychological impacts.
Timeline
Screening ~ 3 weeks3 visits
Treatment ~ Varies
Follow Up ~ 4-months
Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~4-months
Treatment Details
Study Objectives
Study objectives can provide a clearer picture of what you can expect from a treatment.Primary study objectives
Intervention Adherence
Intervention Satisfaction
Secondary study objectives
Diet quality
Percent weight loss maintained
Other study objectives
Incremental cost effective ratio (ICER)
Trial Design
3Treatment groups
Experimental Treatment
Placebo Group
Group I: Noom®Experimental Treatment2 Interventions
Participants will receive a paid Noom® subscription for four-months. Noom® is a subscription-based mobile application that provides food intake and exercise tracking and uses principles from psychology to motivate behavior change.
Group II: Medically tailored mealsExperimental Treatment2 Interventions
Participants will receive 10 medically tailored meals per week (40 meals per month) for four-months.
Group III: Usual carePlacebo Group1 Intervention
Participants will receive usual care from their provider.
Research Highlights
Information in this section is not a recommendation. We encourage patients to speak with their healthcare team when evaluating any treatment decision.Mechanism Of Action
Side Effect Profile
Prior Approvals
Other Research
Common treatments for obesity, such as meal replacements and behavioral treatments, work through different mechanisms to promote weight loss and maintenance. Meal replacements provide a controlled, low-calorie alternative to regular meals, helping to reduce overall caloric intake.
Behavioral treatments involve strategies like self-monitoring, goal setting, and developing coping skills to modify eating behaviors and lifestyle habits. These approaches are crucial for obesity patients as they offer structured and sustainable methods to manage weight, addressing both dietary intake and behavioral factors that contribute to obesity.
Post-operative behavioural management in bariatric surgery: a systematic review and meta-analysis of randomized controlled trials.
Post-operative behavioural management in bariatric surgery: a systematic review and meta-analysis of randomized controlled trials.
Find a Location
Who is running the clinical trial?
UT Southwestern Nutrition Obesity Research CenterUNKNOWN
University of Texas Southwestern Medical CenterLead Sponsor
1,088 Previous Clinical Trials
1,059,650 Total Patients Enrolled
24 Trials studying Obesity
5,332 Patients Enrolled for Obesity
Kelseanna Hollis-Hansen, PhD, MPHPrincipal InvestigatorUT Southwestern Medical Center
2 Previous Clinical Trials
245 Total Patients Enrolled