IV Saline for POTS

Recruiting in Palo Alto (17 mi)

Overseen bySatish R Raj, MD MSCI

Age: 18+

Sex: Any

Travel: May Be Covered

Time Reimbursement: Varies

Trial Phase: Academic

Waitlist Available

Sponsor: Vanderbilt University Medical Center

Approved in 3 Jurisdictions

Trial Summary

What is the purpose of this trial?

The investigators will test whether an intravenous infusion of saline (salt water) will improve the exercise capacity in patients with postural tachycardia syndrome (POTS).

Eligibility Criteria

This trial is for adults aged 18-65 who have been diagnosed with Postural Tachycardia Syndrome (POTS) and can consent to participate. It's not suitable for pregnant individuals, those with conditions that cause rapid heartbeat due to other reasons like dehydration or medications, or if they are bedridden/chair-ridden.

Inclusion Criteria

I am either male or female.

Able and willing to provide informed consent

You have been diagnosed with Postural Tachycardia Syndrome (POTS).

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Exclusion Criteria

I have conditions like dehydration that cause rapid heartbeat when standing.

I am unable to get out of bed or a chair by myself.

Other factors which in the investigator's opinion would prevent the subject from completing the protocol

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Treatment Details

Interventions

Placebo (Other)
Saline (Electrolyte Solution)

Trial OverviewThe study is examining whether giving patients with POTS an IV infusion of saline can improve their ability to exercise. Participants will receive either the saline solution or a placebo during the trial.

Participant Groups

2Treatment groups

Experimental Treatment

Placebo Group

Group I: Exercise Post SalineExperimental Treatment1 Intervention

Saline infusion 1L hours before exercise test

Group II: PlaceboPlacebo Group1 Intervention

Placebo given prior to exercise test

Saline is already approved in United States, European Union, Canada for the following indications:

🇺🇸 Approved in United States as Normal Saline for: