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Corticosteroid

GAE with Embosphere Microspheres for Knee Osteoarthritis (MOTION Trial)

N/A
Recruiting
Led By Sandeep Bagla, MD
Research Sponsored by Merit Medical Systems, Inc.
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Be older than 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up baseline, 3, 6, 12 and 24 months
Awards & highlights
No Placebo-Only Group

Summary

This trial will study if a new procedure (GAE) is better than a steroid injection to treat knee osteoarthritis symptoms over 2 years.

Who is the study for?
This trial is for adults over 21 with knee osteoarthritis who still have pain (score of ≥4 out of 10) despite trying other treatments for at least 3 months. It's not suitable for those planning major surgeries within a month, with advanced artery disease, previous knee replacement on the affected knee, or arthritis due to rheumatoid or infection.
What is being tested?
The study compares two treatments for knee osteoarthritis: genicular artery embolization (GAE) using Embosphere Microspheres and steroid injections. Participants will be randomly assigned to one treatment and followed up for two years to see which is more effective.
What are the potential side effects?
Possible side effects from GAE may include discomfort at the injection site, bruising, and temporary numbness. Steroid injections can cause pain flare-ups, joint infection risks, skin discoloration around the injection area, and weakening of nearby bones.

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~baseline, 3, 6, 12 and 24 months
This trial's timeline: 3 weeks for screening, Varies for treatment, and baseline, 3, 6, 12 and 24 months for reporting.

Treatment Details

Study Objectives

Study objectives can provide a clearer picture of what you can expect from a treatment.
Primary study objectives
Primary Efficacy Endpoint
Primary Safety Endpoint
Secondary study objectives
Numerical rating scale (NRS)
Subjects achieving Clinical Success

Awards & Highlights

No Placebo-Only Group
All patients enrolled in this study will receive some form of active treatment.

Trial Design

2Treatment groups
Experimental Treatment
Active Control
Group I: Genicular artery embolization with Embosphere MicrospheresExperimental Treatment1 Intervention
Device: Embosphere Microspheres Embolic Agent: Embosphere Microspheres
Group II: Corticosteroid Injection of the kneeActive Control1 Intervention
Drug: Corticosteroid injection

Find a Location

Who is running the clinical trial?

Merit Medical Systems, Inc.Lead Sponsor
32 Previous Clinical Trials
3,028 Total Patients Enrolled
Sandeep Bagla, MDPrincipal InvestigatorProstate Centers, USA
3 Previous Clinical Trials
288 Total Patients Enrolled
Craig J McAsey, MDPrincipal InvestigatorAnderson Orthopedic Clinic
~142 spots leftby Apr 2026
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