~33 spots leftby Jan 2026

Exercise Program for Parkinson's Disease

(LifePD Trial)

Recruiting in Palo Alto (17 mi)
Motl, Robert | College of Applied ...
Overseen byRobert Motl, Ph.D
Age: 18+
Sex: Any
Travel: May Be Covered
Time Reimbursement: Varies
Trial Phase: Academic
Waitlist Available
Sponsor: University of Illinois at Chicago
No Placebo Group

Trial Summary

What is the purpose of this trial?

The investigators propose a Stage-I randomized controlled trial (RCT) of a remotely-delivered, 16-week social-cognitive theory-based behavioral intervention focusing on combined exercise (aerobic and resistance) training for yielding increases in device-measured physical activity and improvements in cognitive function, symptoms, and quality of life (QOL), and social-cognitive theory (SCT) outcomes among physically inactive persons with Parkinson's disease (PD). Participants (N=50) will be randomly assigned into exercise training (combined aerobic and resistance exercise) condition or active control (flexibility and stretching) condition. The 16-week intervention will be delivered and monitored remotely within a participant\'s home/community and supported by Zoom-based chats guided by SCT via a behavioral coach. Participants will receive training materials (e.g., prescriptive manual and exercise equipment), one-on-one coaching, action-planning via calendars, self-monitoring via logs, and SCT-based newsletters. The investigators hypothesize that the home-based exercise intervention will yield improvements in cognitive, symptomatic, and QOL outcomes.

Eligibility Criteria

This trial is for physically inactive individuals with Parkinson's Disease who are interested in improving their physical activity, cognitive function, symptoms, and quality of life. Participants will engage in a 16-week program from home using Zoom and must be willing to follow the exercise or stretching routines provided.

Inclusion Criteria

English as a primary language
Confirmed diagnosis of PD
Internet and email access
See 5 more

Exclusion Criteria

Severe cognitive impairment based on a modified Telephone Interview for Cognitive Status (TICS-M) score of less than 18
Above inclusion criteria not met
Moderate or high risk of contraindications for possible injury or death when undertaking strenuous or maximal exercise using the PAR-Q
See 1 more

Treatment Details

Interventions

  • GET Up PD (Behavioural Intervention)
Trial OverviewThe study tests a social-cognitive theory-based behavioral intervention that includes aerobic and resistance exercises (GET Up PD) against an active control group doing flexibility and stretching. It aims to see if the exercise training can improve physical activity levels, cognitive functions, symptoms, and quality of life over 16 weeks.
Participant Groups
2Treatment groups
Experimental Treatment
Active Control
Group I: GET Up PDExperimental Treatment1 Intervention
Remotely-coached/guided, home-based program delivered using telerehabilitation focusing on aerobic fitness and muscle strength as a mode of training
Group II: Stretching and FlexibilityActive Control1 Intervention
Remotely-coached/guided, home-based program delivered using telerehabilitation focusing on stretching and range of motion as the mode of training

Find a Clinic Near You

Research Locations NearbySelect from list below to view details:
University of Illinois at ChicagoChicago, IL
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Who Is Running the Clinical Trial?

University of Illinois at ChicagoLead Sponsor
National Institute on Aging (NIA)Collaborator

References