Pediatric Evolutionary Tumor Board for Cancer
What You Need to Know Before You Apply
What is the purpose of this trial?
This trial aims to develop new treatment strategies for young patients with cancer who lack curative options or have not responded well to standard treatments. A team of specialists reviews each patient's case to suggest innovative therapies or treatment combinations. This trial may suit those whose cancer is unlikely to be cured by standard treatments. Participants must be open to trying new treatment plans and willing to have their medical information, including scans and samples, collected over time. As a Phase 1 trial, the research focuses on understanding how the treatment works in people, offering participants the opportunity to be among the first to receive potentially groundbreaking therapies.
Do I have to stop taking my current medications for the trial?
The trial information does not specify whether you need to stop taking your current medications. It's best to discuss this with the trial team or your doctor.
What prior data suggests that the Pediatric Evolutionary Tumor Board (pedsETB) is safe for patients?
Research shows that the Pediatric Evolutionary Tumor Board (pedsETB) aims to improve cancer treatments for children and young adults. Studies have found that teams like pedsETB, which include experts from various fields, can generate new treatment ideas when current ones prove ineffective.
While specific data on the safety of pedsETB's suggestions is still being collected, their approach does not involve directly altering treatment plans. The board reviews patient information and offers advice without making direct changes. Consequently, there are no reports of the pedsETB itself causing negative effects. Instead, the board focuses on enhancing treatment options using existing therapies.
Since they use established treatments, any risks would align with those already known for these therapies. Patients should consult their doctors about any concerns to understand what this means for their individual situations.12345Why are researchers excited about this trial?
Researchers are excited about this trial because it introduces a fresh approach to treating pediatric and AYA (adolescent and young adult) cancers. Unlike traditional treatments that follow a one-size-fits-all model, this trial leverages an Evolutionary Tumor Board (ETB) to tailor strategies specifically for each patient. The ETB considers the patient's unique clinical history and available options, then suggests personalized strategies such as adaptive therapies or novel dosing schedules. This method aims to outsmart cancer's ability to evolve and resist treatment, potentially leading to more effective and personalized care.
What evidence suggests that the Pediatric Evolutionary Tumor Board (pedsETB) is effective for developing therapeutic strategies in patients with suboptimal outcomes?
Research shows that the Pediatric Evolutionary Tumor Board (pedsETB) is testing a new approach to create treatment plans for children with hard-to-treat cancers. In this trial, the board reviews participants' clinical history, available therapeutic options, and outcome expectations to develop personalized strategies. These plans might involve combining different treatments or adjusting treatment frequency. Early results suggest this method could improve outcomes for some children with cancer. While solid proof of its effectiveness is still pending, the goal is to discover more personalized treatments that work better for these patients.13467
Who Is on the Research Team?
Jonathan Metts, MD
Principal Investigator
Moffitt Cancer Center
Are You a Good Fit for This Trial?
Inclusion Criteria
Timeline for a Trial Participant
Screening
Participants are screened for eligibility to participate in the trial
Review by ETB
Participants' clinical history, available therapeutic options, and outcome expectations are presented to the Evolutionary Tumor Board (ETB) for strategy development
Follow-up
Participants are monitored for the feasibility and effectiveness of the developed therapeutic strategies
What Are the Treatments Tested in This Trial?
Interventions
- Peds Evolutionary Tumor Board (pedsETB)
How Is the Trial Designed?
1
Treatment groups
Experimental Treatment
Participants clinical history, available therapeutic options, and outcome expectations will be presented to the Evolutionary Tumor Board (ETB) along with images and pathology. Strategies and models will be presented regarding additional evolutionary ideas that can be applied. These ideas will be characterized (e.g. first strike-second strike, adaptive, novel sequential therapy, novel combination, novel dosing schedule, etc.).
Find a Clinic Near You
Who Is Running the Clinical Trial?
H. Lee Moffitt Cancer Center and Research Institute
Lead Sponsor
National Pediatric Cancer Foundation
Collaborator
Citations
Generating Novel Translational and Therapeutic - ClinConnect
This clinical trial, called the Pediatric Evolutionary Tumor Board (pedsETB) ... Overall, this trial aims to offer hope and potentially better outcomes for young ...
Projects – National Pediatric Cancer Foundation
The pedsETB will collect data through a chart review regarding adherence and results of ETB recommendation. ... Here, based on the application of evolutionary ...
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publications.aap.org
publications.aap.org/pediatrics/article/152/6/e2023061539/194691/Innovations-in-Cancer-Treatment-of-ChildrenInnovations in Cancer Treatment of Children | Pediatrics
Pediatric cancer outcomes have significantly improved, and yet this success is not spread equally across cancer types or patients.
Feasibility of an Evolutionary Tumor Board for Generating ...
We present the concept of an Evolutionary Tumor Board (ETB) and report interim results from a prospective, non-interventional pilot study.
Innovations in Cancer Treatment of Children - PubMed Central
Pediatric cancer outcomes have significantly improved, and yet this success is not spread equally across cancer types or patients.
The Childhood Cancer Data Initiative: Using the Power of ...
The Childhood Cancer Data Initiative: Using the Power of Data to Learn From and Improve Outcomes for Every Child and Young Adult With Pediatric Cancer
Advancing pediatric oncology and survivorship: A research ...
While chemotherapy and radiation have significantly improved survival rates, they also introduce cardiovascular risks that can shorten those ...
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