Behavioural Intervention
Nerve Stimulation for Childhood Constipation
This trial aims to see if a treatment called posterior tibial nerve stimulation (PTNS) can help children with constipation caused by pelvic floor muscle issues. The study will compare PTNS to a
Microbiota Therapy
Microbiota Transfer Therapy for Autism and Gastrointestinal Disorders
This trial aims to study a treatment called Microbiota Transfer Therapy (MTT) for individuals with Autism-spectrum disorder who also have gastrointestinal issues like constipation, diarrhea, or abdominal pain. M
Procedure
Neostigmine + Glycopyrrolate for Neurogenic Bowel
This trial aims to develop a new method to treat bowel dysfunction in individuals with spinal cord injury. The researchers have created a dual drug combination that can help safely and predictably empty the bowels. They
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Trials for OIC Patients
Probiotics for Childhood Constipation
This trial is testing if adding probiotics to standard treatment helps children with severe constipation feel better faster. Probiotics are good bacteria that can improve digestion and reduce stomach pain. Probiotics have been studied for their potential to alleviate constipation and abdominal pain in children, but the evidence is inconsistent.
Antibiotic
Microbiota Transfer Therapy for Autism and Gastrointestinal Issues
This trial tests a treatment called Microbiota Transfer Therapy (MTT) for children with Autism Spectrum Disorder and gut problems. It uses antibiotics to clear bad bacteria, cleans the bowel, and then adds good bacteria from donor stool over a few months. The goal is to see if this helps improve their symptoms. Microbiota Transfer Therapy (MTT) has shown significant improvements in gastrointestinal and autism symptoms in previous studies, with benefits persisting for some time after treatment.
Trials for Irritable Bowel Syndrome Patients
Small Molecule Inhibitor
Tenapanor for Irritable Bowel Syndrome
This trial aims to understand how a medication called tenapanor affects the gut bacteria and chemicals in patients with irritable bowel syndrome with constipation (IBS-C). Tenapanor is a new medication
Behavioural Intervention
TEA + Lexapro for Irritable Bowel Syndrome
This trial tests TEA and escitalopram on people with IBS-C to see if they can reduce abdominal pain. TEA uses electrical currents on the skin, and escitalopram boosts serotonin in the brain.
Phase 3 Trials
Bile Acid Transport Inhibitor
Maralixibat for Cystic Fibrosis and Constipation
"This trial aims to test whether a new medication, Maralixibat, can improve stool consistency in children under 18 years old with cystic fibrosis and constipation. The medication works by
Guanylate Cyclase-C Agonist
Linaclotide for Pediatric Constipation
This trial will assess the safety and effectiveness of Linaclotide for children with functional constipation. Kids will take Linaclotide or placebo for 12 weeks, then switch to Linaclotide for 24 weeks. Medical assessments, tests and questionnaires will be used to check the effect of the treatment.
Behavioural Intervention
TEA + Lexapro for Irritable Bowel Syndrome
This trial tests TEA and escitalopram on people with IBS-C to see if they can reduce abdominal pain. TEA uses electrical currents on the skin, and escitalopram boosts serotonin in the brain.
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Frequently Asked Questions
Introduction to constipation
What are the top hospitals conducting constipation research?
When it comes to addressing the common condition of constipation, several top hospitals are leading the way in clinical trials. In Anaheim, California, the Advanced Research Center is making strides with three ongoing constipation trials and a total of three completed studies. While this may seem relatively recent compared to other institutions, they have already made significant progress since recording their first constipation trial in 2021. The University of Michigan in Ann Arbor is also actively researching solutions for constipation with three current trials and a history of six previous studies dating back to 2014.
Heading east to Boston's renowned Massachusetts General Hospital, two active constipation trials are underway alongside an impressive track record of eleven completed investigations since their initial involvement in 2006. Similarly dedicated to advancing knowledge and treatment options for constipation, Mayo Clinic in Rochester has two ongoing clinical trials and five previously conducted studies on record since their inaugural trial in 2011.
Even smaller-scale institutions like G & L Research LLC located in Foley, Alabama play a crucial role. They currently have two active constipation trials underway while having contributed significantly over the years through three previously held investigations; their first recorded participation dates back only as far as 2015.
These dedicated hospitals exemplify our collective commitment towards understanding and finding effective solutions for those who suffer from chronic or occasional bouts of constipation. Through groundbreaking research initiatives like these clinical trials, we can gain valuable insights that pave the way for improved treatments and better quality of life for individuals affected by this common yet often underestimated condition
Which are the best cities for constipation clinical trials?
When it comes to constipation clinical trials, several cities are at the forefront of research. Miami, Florida leads with 21 active trials investigating treatments like Linaclotide and Prucalopride. Houston, Texas follows closely behind with 12 ongoing studies focused on Prucalopride and linaclotide. Denver, Colorado also shows promise in constipation research with 11 active trials exploring various treatments. These cities offer individuals experiencing constipation access to cutting-edge clinical trials that may lead to advancements in treatment options and ultimately improve quality of life.
Which are the top treatments for constipation being explored in clinical trials?
Promising treatments for constipation are making strides in clinical trials. One notable contender is Transcutaneous Electrical Acustimulation (TEA), currently undergoing one active trial and two all-time constipation trials since its introduction in 2021. PEG 3350, another noteworthy option, is being explored in one active trial and boasts four all-time constipation trials since 2006. Additionally, Fecobionics shows potential with one ongoing trial and two all-time constipation studies since its listing in 2017. These innovative approaches offer hope for individuals dealing with the challenges of constipation, pushing forward research efforts to find effective solutions.
What are the most recent clinical trials for constipation?
Recent clinical trials have brought new possibilities for the management of constipation. One notable trial investigated the efficacy of PEG 3350, a treatment option that reached Phase 4 and became available on 6/8/2023. Additionally, another Phase 4 intervention focused specifically on addressing constipation also became available on 6/1/2023. In parallel, research is underway to assess the potential benefits of linaclotide in treating constipation through two distinct phases: Part 2 (Phase 2), which emerged on 4/27/2023, and Part 1 (Phase 3) released on12/29/2022. Another promising development is tenapanor, currently in Phase three since it became accessible on February17th,2023.Through these diverse studies conducted at varying stages, clinicians endeavor to improve outcomes for individuals grappling with constipation by expanding our understanding and refining treatment options.
What constipation clinical trials were recently completed?
Recently, a clinical trial focusing on constipation investigated the potential of Pradigastat Tablets 40mg. Sponsored by Anji Pharma, this trial was successfully completed in September 2020. The results of this study contribute valuable insights into the management and treatment options for individuals experiencing constipation.