Pre-Exercise Protein for Perimenopause
(MAAP Trial)
Trial Summary
What is the purpose of this trial?
This trial aims to compare the effects of high-intensity interval training (HIIT) and traditional aerobic exercise on metabolism in overweight or obese women going through perimenopause. The study will also look at how eating protein or carbohydrates before exercise affects these outcomes. The goal is to understand how these exercises and dietary choices can help manage weight and improve metabolic health during perimenopause. High-intensity interval training (HIIT) has been shown to significantly decrease body weight and fat mass, with more pronounced effects in premenopausal women.
Will I have to stop taking my current medications?
The trial requires that you stop taking metabolism-altering drugs or medications, except for estrogen replacement therapy, as they may influence study outcomes.
What data supports the effectiveness of the treatment Non-caloric Placebo water, Whey Protein Isolate, Whey Protein Isolate, WPI for perimenopausal women?
Research shows that milk whey protein, particularly its basic protein fraction, can improve bone health by increasing bone mineral density in perimenopausal women. This suggests that whey protein isolate, a component of the treatment, may help maintain or improve bone health in this population.12345
How does pre-exercise protein differ from other treatments for perimenopause?
Pre-exercise protein, particularly milk basic protein (MBP), is unique because it helps increase bone mineral density by promoting bone formation and inhibiting bone resorption, which is beneficial for bone health in perimenopausal women. This approach is different from other treatments as it focuses on maintaining bone health through dietary supplementation rather than medication.12678
Research Team
Abbie Smith-Ryan, PhD
Principal Investigator
University of North Carolina
Eligibility Criteria
This trial is for early and late perimenopausal women aged 38 or older who are overweight (BMI: 28-40) with a body fat percentage of 30% or higher. They must be non-smokers, not currently pregnant or nursing, and have had changes in menstrual cycle regularity. Women with cardiovascular, metabolic disorders, recent weight fluctuations, or those on certain medications cannot participate.Inclusion Criteria
Exclusion Criteria
Trial Timeline
Screening
Participants are screened for eligibility to participate in the trial
Treatment
Participants engage in high intensity interval training (HIIT) and traditional aerobic exercise, with pre-exercise carbohydrate or protein ingestion
Follow-up
Participants are monitored for metabolic responses, including energy expenditure and respiratory exchange ratio, after exercise
Treatment Details
Interventions
- Non-caloric Placebo water (Other)
- Whey Protein Isolate (Other)
Find a Clinic Near You
Who Is Running the Clinical Trial?
University of North Carolina, Chapel Hill
Lead Sponsor
American Diabetes Association
Collaborator