Dietary Intervention for Prediabetes

Palo Alto (17 mi)

Age: 18+

Sex: Any

Travel: May be covered

Time Reimbursement: Varies

Trial Phase: N/A

Waitlist Available

Sponsor: Stanford University

No Placebo Group

Trial Summary

What is the purpose of this trial?1 in 3 adults have prediabetes in the United States, and many of them will eventually develop diabetes, which has significant public health and economic costs. However, type 2 diabetes (T2D) and prediabetes are heterogeneous groups with different pathological mechanisms, dysfunctions in different processes, and varied disease trajectories. Patient stratifications into subtypes and personalized nutrition interventions are highly needed but not yet available. Metabolic responses (e.g., glucose excursion) after food intake provide a direct observation of personal metabolic control and its association with T2D. The investigators hope to learn how prediabetes and type 2 diabetes evolve, and specifically what food or exercise can do to mitigate blood sugar response.

Eligibility Criteria

This trial is for generally healthy adults over 18 living near Stanford who have prediabetes or type 2 diabetes managed by diet or metformin. Participants must not be pregnant, have cognitive impairments, malabsorptive disorders, major organ diseases, a history of bariatric surgery, heavy alcohol use, recent significant weight change, or be on certain medications.

Inclusion Criteria

I am 18 years old or older.

Exclusion Criteria

I have a condition that affects how my body absorbs nutrients, like celiac disease.

I am currently using weight loss medications or following a specific diet.

I have had weight loss surgery in the past.

I am able to understand and follow the study's requirements.

I do not have any major organ diseases.

I am taking diabetes medication other than metformin.

Treatment Details

The study aims to understand how different foods and exercises affect blood sugar control in people with prediabetes and type 2 diabetes. It will involve dietary interventions to see if personalized nutrition can help manage these conditions.

1Treatment groups

Experimental Treatment

Group I: mitigatorExperimental Treatment1 Intervention

Test different foods to see their mitigating effect on blood sugars after a rice meal.