Motivational Interviewing + Air Cleaners for COPD
(MOVE-COPD Trial)

Recruiting in Palo Alto (17 mi)

+1 other location

Overseen byNadia N Hansel, MD, MPH

Age: 18+

Sex: Any

Travel: May Be Covered

Time Reimbursement: Varies

Trial Phase: Academic

Waitlist Available

Sponsor: Johns Hopkins University

No Placebo Group

Trial Summary

What is the purpose of this trial?

COPD is characterized by lung injury and inflammation caused by noxious particles and gases, including those emanating from cigarette smoke and air pollution. Despite the clear detrimental impact of poor air quality on respiratory outcomes, regardless of smoking status, to investigators' knowledge, there are no studied environmental interventions targeting indoor air quality to improve respiratory health of smokers, thus ignoring a potential target for harm reduction. Investigators propose a randomized controlled intervention trial to test whether targeted reductions of multiple indoor pollutants (PM, SHS and NO2) in homes of smokers with COPD will improve respiratory outcomes. Investigators have chosen a potent, multimodal intervention (active air cleaners + Motivational intervention for SHS reduction) in order to maximize the opportunity to prove that there is a health benefit to active smokers with COPD from indoor air pollution reduction.

Research Team

Nadia N Hansel, MD, MPH

Principal Investigator

Johns Hopkins University

Eligibility Criteria

The MOVE COPD trial is for current smokers over 40 years old with a physician's diagnosis of moderate to severe COPD. Participants must have smoked the equivalent of at least 10 packs of cigarettes per year and not enforce a smoking ban in their homes. They cannot have other chronic lung diseases, live outside their home, plan to move during the study period, or be on long-term systemic corticosteroids.

Inclusion Criteria

You are currently a smoker and have a high level of carbon monoxide in your breath.

I am 40 years old or older.

My doctor has diagnosed me with COPD.

See 3 more

Exclusion Criteria

I am on long-term steroids for another condition.

Home owner or occupant planning to move or change residence within study period

Living in location other than home (e.g., long term care facility)

See 2 more

Treatment Details

Interventions

Active HEPA Air Cleaner (Procedure)
Motivational interviewing (Behavioral Intervention)
Sham Air Cleaner (Procedure)

Trial OverviewThis study tests if using active HEPA air cleaners and motivational interviewing can improve respiratory health in smokers with COPD by reducing indoor air pollution. It's a randomized controlled trial where some participants will receive sham (fake) air cleaners as a comparison.

Participant Groups

2Treatment groups

Active Control

Placebo Group

Group I: Active TreatmentActive Control2 Interventions

The active treatment arm will receive two portable active HEPA air cleaners as well as 4 sessions of phone based motivational interviewing to support a home smoking ban and SHS reduction (in addition to the smoking cessation counseling received by all study participants).

Group II: Control ArmPlacebo Group1 Intervention

Homes in the control group will receive Sham air cleaners that have the internal HEPA filter removed, but which will run normally, including similar noise, airflow and overall appearance compared to active air cleaners, thus blinding participants to filter status. The control arm will not receive phone based motivational interviewing to support a home smoking ban and SHS reduction, they will receive only smoking cessation counseling.