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Motivational Interviewing + Air Cleaners for COPD (MOVE-COPD Trial)

N/A

Waitlist Available

Led By Nadia N Hansel, MD

Research Sponsored by Johns Hopkins University

Eligibility Criteria Checklist

Specific guidelines that determine who can or cannot participate in a clinical trial

Must have

Age ≥ 40 years

Physician diagnosis of COPD

Must not have

Chronic systemic corticosteroids

Other chronic lung disease including asthma

Timeline

Screening 3 weeks

Treatment Varies

Follow Up baseline, 3 month and 6 months post-randomization

Summary

This trial will test whether reducing indoor air pollution for smokers with COPD will improve their respiratory outcomes.

Who is the study for?

The MOVE COPD trial is for current smokers over 40 years old with a physician's diagnosis of moderate to severe COPD. Participants must have smoked the equivalent of at least 10 packs of cigarettes per year and not enforce a smoking ban in their homes. They cannot have other chronic lung diseases, live outside their home, plan to move during the study period, or be on long-term systemic corticosteroids.

What is being tested?

This study tests if using active HEPA air cleaners and motivational interviewing can improve respiratory health in smokers with COPD by reducing indoor air pollution. It's a randomized controlled trial where some participants will receive sham (fake) air cleaners as a comparison.

What are the potential side effects?

Since this trial involves non-medical interventions like air cleaners and counseling sessions, there are no direct side effects from medications or procedures. However, any changes in behavior or environment may indirectly affect participants' well-being.

Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below

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I am 40 years old or older.

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My doctor has diagnosed me with COPD.

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My lung condition is moderate to very severe based on breathing tests.

Exclusion Criteria

You may be eligible for the trial if you check “No” for criteria below:

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I am on long-term steroids for another condition.

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I have a chronic lung condition, such as asthma.

Timeline

Screening ~ 3 weeks3 visits

Treatment ~ Varies

Follow Up ~ baseline, 3 month and 6 months post-randomization

Screening ~ 3 weeks

Treatment ~ Varies

Follow Up ~baseline, 3 month and 6 months post-randomization

This trial's timeline: 3 weeks for screening, Varies for treatment, and baseline, 3 month and 6 months post-randomization for reporting.

Treatment Details

Study Objectives

Study objectives can provide a clearer picture of what you can expect from a treatment.

Primary study objectives

Change in Dyspnea as assessed by the University of California San Diego Shortness of Breath Questionnaire (SDSOBQ)

Change in Quality of Life

Secondary study objectives

Change in COPD health status

Change in Dyspnea as assessed by modified medical research Council questionnaire(mMRC)

Change in aggregate Health Care Utilization (number of episodes reported due to COPD-related exacerbation)

+2 more

Other study objectives

Change in Markers of oxidative stress in urine (8-isoprostane)

Change in Systemic markers of inflammation in serum (C-reactive protein)

Change in Systemic markers of inflammation in serum (Interleukin-8)

Trial Design

2Treatment groups

Active Control

Placebo Group

Group I: Active TreatmentActive Control2 Interventions

The active treatment arm will receive two portable active HEPA air cleaners as well as 4 sessions of phone based motivational interviewing to support a home smoking ban and SHS reduction (in addition to the smoking cessation counseling received by all study participants).

Group II: Control ArmPlacebo Group1 Intervention

Homes in the control group will receive Sham air cleaners that have the internal HEPA filter removed, but which will run normally, including similar noise, airflow and overall appearance compared to active air cleaners, thus blinding participants to filter status. The control arm will not receive phone based motivational interviewing to support a home smoking ban and SHS reduction, they will receive only smoking cessation counseling.

0 / 5Eligibility criteria met