← Back to Search

Behavioural Intervention

Recovery Management Checkups for Opioid Use Disorder (RETAIN Trial)

N/A

Waitlist Available

Led By Simeon Kimmel, MD

Research Sponsored by Boston Medical Center

Eligibility Criteria Checklist

Specific guidelines that determine who can or cannot participate in a clinical trial

Must have

Between 18 and 65 years of age

Admitted to Boston Medical Center on any inpatient unit for an active serious injection related infection (SIRI) such as endocarditis, osteomyelitis, bacteremia, septic arthritis, epidural abscess or other serious infection in which two weeks or more of antibiotics are recommended

Must not have

Not able to give informed consent

Timeline

Screening 3 weeks

Treatment Varies

Follow Up baseline while hospitalized, then 2 weeks, 6 weeks, 3 months, and 6 months after discharge

Awards & highlights

No Placebo-Only Group

Summary

This trial is testing a new version of a treatment program for opioid use disorder (OUD) called Recovery Management Checkups (RMC) that is tailored for people who have been hospitalized with serious injection

Who is the study for?

The RETAIN trial is for individuals who have been hospitalized with serious injection-related infections (SIRI) like sepsis or endocarditis and also struggle with opioid use disorder. It's designed to help them stay on treatment after hospitalization.

What is being tested?

This pilot study tests an adapted intervention called Recovery Management Checkups (RMC), which aims to improve long-term treatment retention in patients recovering from SIRI and OUD. Participants will receive the RMC intervention, while its feasibility and preliminary efficacy are assessed.

What are the potential side effects?

Since this trial focuses on a behavioral intervention rather than medication, traditional side effects related to drugs are not applicable. However, participants may experience emotional discomfort discussing their addiction.

Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below

Select...

I am between 18 and 65 years old.

Select...

I am admitted to Boston Medical Center for a serious infection needing 2+ weeks of antibiotics.

Exclusion Criteria

You may be eligible for the trial if you check “No” for criteria below:

Select...

I am unable to understand or sign the consent form.

Timeline

Screening ~ 3 weeks3 visits

Treatment ~ Varies

Follow Up ~ baseline while hospitalized, then 2 weeks, 6 weeks, 3 months, and 6 months after discharge

Screening ~ 3 weeks

Treatment ~ Varies

Follow Up ~baseline while hospitalized, then 2 weeks, 6 weeks, 3 months, and 6 months after discharge

This trial's timeline: 3 weeks for screening, Varies for treatment, and baseline while hospitalized, then 2 weeks, 6 weeks, 3 months, and 6 months after discharge for reporting.

Treatment Details

Study Objectives

Study objectives can provide a clearer picture of what you can expect from a treatment.

Primary study objectives

Acceptability of the RETAIN Intervention

Feasibility of the RETAIN Intervention based on completion of study visits

Number of days on medications for opioid disorder (MOUD)

+1 more

Secondary study objectives

MOUD stigma

Number of Hospitalizations

Number of days of Opioid use

+3 more

Awards & Highlights

No Placebo-Only Group

All patients enrolled in this study will receive some form of active treatment.

Trial Design

2Treatment groups

Experimental Treatment

Active Control

Group I: RETAIN interventionExperimental Treatment1 Intervention

Participants randomized to the RETAIN intervention will receive Motivational Interviewing targeted to their clinical concerns and personalized support tailored to each participants' specific needs determined by their answers to intake questions.

Group II: ControlActive Control1 Intervention

Control arm participants will be offered different videos or podcast episodes that are unrelated to the study topics of infections, substance use, overdose, and medication management.

0 / 3Eligibility criteria met