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Behavioural Intervention

Peer Support for Polysubstance Abuse (PRISM Trial)

N/A

Recruiting

Led By Sarah M Kattakuzhy, MD

Research Sponsored by University of Maryland, College Park

Eligibility Criteria Checklist

Specific guidelines that determine who can or cannot participate in a clinical trial

Must have

Be older than 18 years old

Timeline

Screening 3 weeks

Treatment Varies

Follow Up measured from intake to six-month follow-up

Awards & highlights

No Placebo-Only Group

Summary

This trial will test a peer-led intervention to help opioid use disorder patients in an underserved, rural area adhere to medication and reduce polysubstance use.

Who is the study for?

This trial is for adults over 18 with opioid use disorder and polysubstance use in a rural area, who have struggled to stick to their medication plan or haven't refilled their pharmacy prescription recently. It's not for those with untreated severe mental health issues or pregnant individuals.

What is being tested?

The study tests 'Peer Activate,' a peer-led program aiming to improve adherence to opioid addiction medications and reduce the use of multiple substances. Participants will either receive this new intervention or the usual treatment, and they'll be followed for twelve months.

What are the potential side effects?

Since 'Peer Activate' involves behavioral support rather than medication, side effects are minimal compared to drug treatments. However, participants may experience emotional discomfort when discussing substance use habits.

Timeline

Screening ~ 3 weeks3 visits

Treatment ~ Varies

Follow Up ~ measured over 12 months

Screening ~ 3 weeks

Treatment ~ Varies

Follow Up ~measured over 12 months

This trial's timeline: 3 weeks for screening, Varies for treatment, and measured over 12 months for reporting.

Treatment Details

Study Objectives

Study objectives can provide a clearer picture of what you can expect from a treatment.

Primary study objectives

Six-Month Polysubstance Use Self Report

Six-Month Polysubstance Use Urinalysis

Secondary study objectives

Intervention Fidelity

Intervention Session Attendance

Intervention Uptake

+4 more

Other study objectives

Overdose risk

Six-month Criminal and Legal Activities

Six-month Health-related Quality of Life

+15 more

Awards & Highlights

No Placebo-Only Group

All patients enrolled in this study will receive some form of active treatment.

Trial Design

2Treatment groups

Experimental Treatment

Active Control

Group I: Peer-Delivered Behavioral Activation ("Peer Activate")Experimental Treatment1 Intervention

Participants in the Peer Activate intervention will receive a PRS-delivered behavioral activation intervention to address barriers to retention in methadone treatment and increase substance-free, positive reinforcement to support retention and reduce polysubstance use.

Group II: Treatment As UsualActive Control1 Intervention

Participants in the TAU group will receive enhanced treatment as usual, defined as MTU services as usual enhanced with additional community referrals and follow-ups on those referrals, in addition to regular meetings with an addiction medicine physician and PRS on the MTU. Standard PRS contact typically includes connection to local resources and general peer support as needed.

Do I qualify?Apply below to find out