Dental Health Assessment for Esophageal Cancer
Recruiting in Palo Alto (17 mi)
Age: 18+
Sex: Any
Travel: May Be Covered
Time Reimbursement: Varies
Trial Phase: Academic
Recruiting
Sponsor: Memorial Sloan Kettering Cancer Center
Disqualifiers: Significant molar dental work, others
No Placebo Group
Trial Summary
What is the purpose of this trial?The researchers are doing this study to find out more about what may lead to the loss of tooth enamel (the thin outer covering of the tooth) and how often it happens in people with esophagogastric cancer, colorectal cancer, pancreatic cancer, breast cancer, head and neck cancer, or non-small cell lung cancer, or a healthy volunteer.
Do I need to stop my current medications for this trial?
The trial protocol does not specify whether you need to stop taking your current medications.
What data supports the idea that Dental Health Assessment for Esophageal Cancer is an effective treatment?
The available research does not provide specific data supporting the effectiveness of Dental Health Assessment for Esophageal Cancer. Instead, it focuses on other treatments like surgery, chemotherapy, and radiation. These treatments, especially when combined, have shown some improvement in survival rates and resectability of tumors. However, there is no mention of Dental Health Assessment being used or evaluated for esophageal cancer in the provided research.
12345What safety data exists for intraoral cameras used in dental health assessments?
The provided research does not directly address safety data for intraoral cameras. However, it discusses their increasing use in dentistry, their role in remote risk assessment and monitoring of oral lesions, and their application in clinical photography. The studies focus on image quality, ease of use, and recommendations for effective use, but do not specifically mention safety concerns or data.
678910Is the treatment in the trial 'Dental Health Assessment for Esophageal Cancer' a promising treatment?
Yes, the treatment is promising because improving dental health can help reduce the risk of severe pneumonia after surgery for esophageal cancer, and it may also be linked to better overall outcomes for patients.
711121314Eligibility Criteria
This study is for adults over 18 with esophagogastric cancer who can understand English or have translation services. They should be able to complete a survey and allow photos of their teeth, but those without teeth or major dental work on molars that affects enamel assessment cannot join.Inclusion Criteria
Subject is willing and able to provide written informed consent
I am 18 years old or older.
Patients must be able to understand English language or have access to adequate translation services
+2 more
Exclusion Criteria
I have never had cancer (other than skin cancer) and am not being evaluated for reflux.
I don't have molars or have had significant dental work on them.
Trial Timeline
Screening
Participants are screened for eligibility to participate in the trial
2-4 weeks
Dental Imaging and Survey
Participants complete a survey and undergo dental imaging; optional saliva sample collection for esophagogastric cancer patients
1-2 weeks
1 visit (in-person)
Follow-up
Participants are monitored for the incidence of dental erosions over a year
1 year
Participant Groups
The study aims to understand tooth enamel loss in people with various cancers including esophagogastric cancer. Participants will provide saliva samples, answer surveys about their oral health, and have pictures taken of their teeth using an intra-oral camera.
3Treatment groups
Experimental Treatment
Group I: Patients diagnosed with esophagogastric cancerExperimental Treatment3 Interventions
Patients have completed the intervention once completing the survey, undergoing dental imaging and future patients will also provide an optional saliva sample.
Group II: Patients diagnosed with colorectal, pancreatic, breast, head and neck, or non-small cell lung cancerExperimental Treatment2 Interventions
Patients undergo consenting and dental imaging during their routine visits at MSK.
Group III: Healthy volunteers who have not been diagnosed with cancerExperimental Treatment2 Interventions
Healthy controls will be defined as those without a known or suspected invasive cancer history and excluding those undergoing a procedure for symptomatic reflux.
Find a Clinic Near You
Research Locations NearbySelect from list below to view details:
Memorial Sloan Kettering Cancer Center (All Protocol Activities)New York, NY
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Who Is Running the Clinical Trial?
Memorial Sloan Kettering Cancer CenterLead Sponsor
References
Assessment of a collaborative treatment model for trimodal management of esophageal cancer. [2023]Patients with esophageal cancer often receive care in a collaborative (multi-institutional) treatment model as opposed to a single institutional model. The effect of a collaborative model on the quality of trimodality therapy and survival is unknown.
Implementation of a regional video multidisciplinary team meeting is associated with an improved prognosis for patients with oesophageal cancer A mixed methods approach. [2022]Studies have shown that multidisciplinary team meetings (MDTM) improve diagnostic work-up and treatment-decisions. This study aims to evaluate the influence of implementing a regional-video-Upper-GI-MDTM (uMDTM) for oesophageal cancer (OC) on the number of patients discussed, treatment-decisions, perspectives of involved clinicians and overall survival (OS) in the Eindhoven Upper-GI Network consisting of 1 resection hospital and 5 referring hospitals.
Molecular response prediction in multimodality treatment for adenocarcinoma of the esophagus and esophagogastric junction. [2018]Cancers arising from the esophagus are becoming more common in the United States and Europe. In 2009, an estimate of 14,530 new cases will be diagnosed and more than 90% will die of their disease. Esophageal cancer is currently the most rapidly increasing cancer in the western world and is coinciding with a shift in histological type and primary tumor location. Despite recent improvements in the detection, surgical resection, and (radio-) chemotherapy, the overall survival (OS) of esophageal cancer remains relatively poor. It is becoming increasingly apparent that neoadjuvant chemoradiation followed by surgery may be beneficial in terms of increasing resectability and OS compared to surgery alone. Results from clinical trials are encouraging; however, they also demonstrated that only patients with major histopathological response (pCR) will benefit from neoadjuvant therapy. In addition, these therapies are expensive and the prognoses of patients who do not respond to trimodality treatment strategies appear to be inferior to that of patients who had surgery alone. Accordingly, the development of validated predictive molecular markers may not only be helpful in identifying EA patients who are more likely to respond, but they will also be critical in selecting more efficient treatment strategies with the means of a tailored, targeted, and effective therapy to the molecular profile of both the patient and their disease while minimizing and avoiding life-threatening toxicities.
[Esophagus carcinoma: radical concepts]. [2008]Esophageal cancer is one of the most malignant tumors in man. A better understanding of the biology of esophageal cancer as well as surgical technical advances have significantly improved the treatment of esophageal cancer patients. A careful risk analysis is crucial for a reduced postoperative mortality and anastomotic failure rate and neoadjuvant therapy facilitates down staging of tumours, thus aiding in high resectability rates with significantly improved long term survival in patients with esophageal cancer.
Combined modality therapy of esophageal cancer. [2019]Esophageal cancer is a deadly disease. Only one third of patients with localized disease experience long-term survival. Over the past 20 years, investigators have evaluated neoadjuvant strategies to improve the outcomes of surgical management. Chemotherapy and radiation have been evaluated individually and in combination for preoperative management of patients with localized esophageal cancer. This article provides a critical review of the data on multimodality approaches to the management of esophageal cancer.
A systematic evaluation of intraoral cameras. [2015]Although intraoral cameras are being used with increasing frequency in dentistry, this is the first systematic evaluation of the technology. This paper summarizes the evaluation of five intraoral cameras and discusses techniques that practitioners can use in conducting their own evaluations. Additionally, issues specific to intraoral camera evaluations, including image quality, ease of use and the differences between analog and digital cameras, are summarized. Finally, a call is made for an ongoing series of intraoral camera evaluations that would provide practitioners with the information they need to make a purchase decision.
Intraoral Photography Recommendations for Remote Risk Assessment and Monitoring of Oral Mucosal Lesions. [2022]Oral cancer is a global health issue with substantial morbidity and a high mortality rate mainly because of late-stage diagnosis. Cancerous lesions are often preceded by potentially malignant lesions that may be detected during routine dental examinations. Not only is the oral cavity easily accessible for screening, but the clinical risk factors of the disease are also known. However, patients may not always be able to access screening services or receive follow-up for diagnosed lesions. In these circumstances, intraoral photos are crucial for timely triage, risk assessment, and monitoring of oral lesions. Further, photos form an integral part of a patient's records, facilitate patient education and communication between health care providers, and provide important information during the referral process. To ensure that intraoral photos are of good quality and standardised there is a need to establish recommendations regarding intraoral photography in oral mucosal screening. This article recommends methods to help health professionals and patients obtain interpretable intraoral photographs. Suggestions to achieve ideal lighting, mirror placement, camera angle, and retraction have been discussed. These recommendations are adaptable to easily available smartphone or point-and-shoot cameras and may be further used to develop future teledentistry platforms.
Use of dental photography by general dental practitioners in Great Britain. [2018]This study assesses, by means of a postal questionnaire, the numbers of general dental practitioners who use clinical photography, and the uses to which this is applied. The questionnaire was distributed to 1000 randomly selected GDPs in Great Britain. A response rate of 76% was achieved. Of the respondents, 36% used clinical photography, with 65% of those using an intra-oral 35 mm camera, 18% a digital camera and 12% an intra-oral digital video camera. Principal uses of clinical photography were patient instruction/motivation (72%), medico-legal reasons (68%), treatment planning (63%), and liaison with laboratory (43%).
Clinical recommendations for the use of D-speed film, E-speed film, and xeroradiography. [2019]This article assesses the diagnostic utility, radiation dose, equipment reliability, patient acceptance, and costs associated with D-speed film, E-speed film, and dental xeroradiographs for intraoral imaging. From the analysis and review of laboratory studies and clinical trials, conclusions and recommendations are offered.
Dental screenings using telehealth technology: a pilot study. [2006]This pilot study compared data obtained using traditional methods of visual dental screenings in a school setting with data obtained using an intraoral camera and transmitted to a distant location via telehealth technology.
[Detection strategies and risk factors in oral cancers]. [2011]Current methods used by health providers in early detection of oral cancers have some shortcomings, this is why, besides the clinical examination that combines the study of the head and neck, oral cavity, and the evaluation of general health status, now are available new ones, like intra oral camera, digital imaging, and computerized expert systems which offer new opportunities for clinically significant data collection, analysis, storing and use. Oral cancers are part of the upper aero-digestive cancers therefore they share the same epidemiologic features and risk factors. Main risk factors are tobacco and alcohol consumption. In the last decades, compared to men, women are increasingly exposed to these risk factors. Oral diagnostic specialties can offer a pro-active influence in the research of oral cancers and both professional and oral research associations can participate in establishing new strategies in oral cancers early detection.
Using NHANES oral health examination protocols as part of an esophageal cancer screening study conducted in a high-risk region of China. [2018]The oral health status of rural residents in the People's Republic of China has not been extensively studied and the relationship between poor oral health and esophageal cancer (EC) is unclear. We aim to report the oral health status of adults participating in an EC screening study conducted in a rural high-risk EC area of China and to explore the relationship between oral health and esophageal dysplasia.
Polish public caries prophylaxis programme for children aged 5, 7 and 15 years, implemented in the year 2011. [2019]Continuous monitoring of oral health status improves the quality of dental health care and the effectiveness of implemented prevention programs.
Esophageal Cancer Patients Have a High Incidence of Severe Periodontitis and Preoperative Dental Care Reduces the Likelihood of Severe Pneumonia after Esophagectomy. [2017]Poor oral health is a risk factor for causing upper aerodigestive tract tumors, including esophageal cancer. Our aim was to determine the periodontitis rate in our cohort of esophageal cancer patients. We also analyzed whether preoperative dental examination and care reduces the likelihood of severe pneumonia after esophagectomy.