Personalized Diet for Inflammatory Bowel Disease
Recruiting in Palo Alto (17 mi)
+1 other location
Age: < 65
Sex: Any
Travel: May Be Covered
Time Reimbursement: Varies
Trial Phase: Academic
Recruiting
Sponsor: University of Manitoba
Must not be taking: Antibiotics, Probiotics, Steroids
Disqualifiers: Abdominal surgery, Enteric infection, Systemic disease, others
Trial Summary
What is the purpose of this trial?This study aims to examine patient tolerability of personalized dietary fibre consumption recommendations (high-pectin diet versus high-B-fructan diet based on personalized responses), provided by an IBD dietician, based on our novel translational research findings.
Do I have to stop taking my current medications for this trial?
The trial requires that your current IBD treatment be stable, meaning no changes in biologics or immunomodulators in the last month. You cannot be on systemic steroids above 10 mg/day of Prednisone or have had a recent change in IBD treatment. If your treatment is stable, you likely won't need to stop your current medications.
What data supports the idea that Personalized Diet for Inflammatory Bowel Disease is an effective treatment?
The available research shows that there is not enough strong evidence to make firm dietary recommendations for treating Inflammatory Bowel Disease (IBD) with a personalized diet. While some studies mention that patients often report certain foods affecting their symptoms, there is no clear data supporting the effectiveness of a Personalized Diet for IBD. Other diets, like the low FODMAP diet, are more commonly discussed and have some evidence suggesting they might help manage symptoms. However, the overall lack of rigorous scientific evidence makes it difficult to conclude that a Personalized Diet is an effective treatment for IBD.
12345What safety data exists for personalized diets in treating inflammatory bowel disease?
The safety data for personalized diets, such as those involving beta2-1 fructans, in treating inflammatory bowel disease (IBD) is limited but promising. Studies suggest that beta2-1 fructans, which are prebiotic fibers, can modulate immune function and reduce intestinal inflammation. Animal studies have shown benefits in immune response and inflammation, while human studies have reported some positive effects on IBD. However, many studies are small and not well-controlled, indicating a need for more rigorous research to confirm these findings.
12567Is the Personalized B-fructan diet a promising treatment for Inflammatory Bowel Disease?
The Personalized B-fructan diet could be promising for treating Inflammatory Bowel Disease because diet plays an important role in managing the condition. While there isn't strong scientific evidence yet, many patients believe specific diets help their symptoms, and ongoing research is exploring these possibilities.
45789Eligibility Criteria
This trial is for children (6-17) and young adults (18-39) with Ulcerative Colitis or IBD, who are not in severe condition (Mayo score <10). They should be undergoing a colonoscopy but not on steroids, and their treatment hasn't changed recently. Non-IBD individuals and healthy family members can also participate as controls.Inclusion Criteria
My current treatment hasn't changed in the last month and I'm not on steroids.
My condition affects the middle to lower parts of my body.
I either have or am suspected to have ulcerative colitis or indeterminate colitis.
+4 more
Trial Timeline
Screening
Participants are screened for eligibility to participate in the trial
2-4 weeks
Treatment
Participants receive personalized dietary fibre recommendations (high-pectin diet versus high-B-fructan diet) based on personalized responses
12 weeks
4 visits (in-person) at weeks 1, 4, 8, and 12
Follow-up
Participants are monitored for safety and effectiveness after treatment
4 weeks
Participant Groups
The study tests if personalized diets high in either pectin or B-fructan fibers, recommended by an IBD dietician based on individual responses, can be tolerated well by patients with Inflammatory Bowel Disease.
4Treatment groups
Experimental Treatment
Placebo Group
Group I: Personalized pectin dietExperimental Treatment1 Intervention
Group II: Personalized B-fructan dietExperimental Treatment1 Intervention
Group III: Randomized pectin dietPlacebo Group1 Intervention
Group IV: Randomized B-fructan dietPlacebo Group1 Intervention
Find a Clinic Near You
Research Locations NearbySelect from list below to view details:
Health Sciences Centre HospitalWinnipeg, Canada
University of Alberta HospitalEdmonton, Canada
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Who Is Running the Clinical Trial?
University of ManitobaLead Sponsor
References
Is a low FODMAP diet beneficial for patients with inflammatory bowel disease? A meta-analysis and systematic review. [2019]To assess the current evidence regarding the benefit of a low fermentable oligosaccharides, disaccharides, monosaccharides, and polyol (FODMAP) diet in the treatment of patients with inflammatory bowel disease (IBD).
Components of the Fiber Diet in the Prevention and Treatment of IBD-An Update. [2023]Inflammatory bowel disease (IBD) is a group of diseases with a chronic course, characterized by periods of exacerbation and remission. One of the elements that could potentially predispose to IBD is, among others, a low-fiber diet. Dietary fiber has many functions in the human body. One of the most important is its influence on the composition of the intestinal microflora. Intestinal dysbiosis, as well as chronic inflammation that occurs, are hallmarks of IBD. Individual components of dietary fiber, such as β-glucan, pectin, starch, inulin, fructooligosaccharides, or hemicellulose, can significantly affect preventive effects in IBD by modulating the composition of the intestinal microbiota or sealing the intestinal barrier, among other things. The main objective of the review is to provide information on the effects of individual fiber components of the diet on the risk of IBD, including, among other things, altering the composition of the intestinal microbiota.
Nutrient, Fibre, and FODMAP Intakes and Food-related Quality of Life in Patients with Inflammatory Bowel Disease, and Their Relationship with Gastrointestinal Symptoms of Differing Aetiologies. [2022]Certain foods are reported as gut symptom triggers in inflammatory bowel disease [IBD], and fructans are shown to worsen non-inflammatory symptoms in inactive IBD, which may result in self-imposed dietary restrictions. The aim of this study was to investigate nutrient and FODMAP intakes, and the relationship between gut symptoms and dietary intake, in IBD.
Dietary patterns and self-reported associations of diet with symptoms of inflammatory bowel disease. [2021]There are insufficient data to make firm dietary recommendations for patients with inflammatory bowel disease (IBD). Yet patients frequently report that specific food items influence their symptoms. In this study, we describe patients' perceptions about the benefits and harms of selected foods and patients' dietary patterns.
Diet and Inflammatory Bowel Disease. [2020]Patients with inflammatory bowel disease (IBD) are increasingly becoming interested in nonpharmacologic approaches to managing their disease. One of the most frequently asked questions of IBD patients is what they should eat. The role of diet has become very important in the prevention and treatment of IBD. Although there is a general lack of rigorous scientific evidence that demonstrates which diet is best for certain patients, several diets-such as the low-fermentable oligosaccharide, disaccharide, monosaccharide, and polyol diet; the specific carbohydrate diet; the anti-inflammatory diet; and the Paleolithic diet-have become popular. This article discusses the diets commonly recommended to IBD patients and reviews the supporting data.
Prebiotics, immune function, infection and inflammation: a review of the evidence. [2009]Beta2-1 fructans are carbohydrate molecules with prebiotic properties. Through resistance to digestion in the upper gastrointestinal tract, they reach the colon intact, where they selectively stimulate the growth and/or activity of beneficial members of the gut microbiota. Through this modification of the intestinal microbiota, and by additional mechanisms, beta2-1 fructans may have beneficial effects upon immune function, ability to combat infection, and inflammatory processes and conditions. In this paper, we have collated, summarised and evaluated studies investigating these areas. Twenty-one studies in laboratory animals suggest that some aspects of innate and adaptive immunity of the gut and the systemic immune systems are modified by beta2-1 fructans. In man, two studies in children and nine studies in adults indicate that the adaptive immune system may be modified by beta2-1 fructans. Thirteen studies in animal models of intestinal infections conclude a beneficial effect of beta2-1 fructans. Ten trials involving infants and children have mostly reported benefits on infectious outcomes; in fifteen adult trials, little effect was generally seen, although in specific situations, certain beta2-1 fructans may be beneficial. Ten studies in animal models show benefit of beta2-1 fructans with regard to intestinal inflammation. Human studies report some benefits regarding inflammatory bowel disease (four positive studies) and atopic dermatitis (one positive study), but findings in irritable bowel syndrome are inconsistent. Therefore, overall the results indicate that beta2-1 fructans are able to modulate some aspects of immune function, to improve the host's ability to respond successfully to certain intestinal infections, and to modify some inflammatory conditions.
Therapeutic Implications of Diet in Inflammatory Bowel Disease and Related Immune-Mediated Inflammatory Diseases. [2022]Despite being a focal issue to patients, the effect of diet on adult inflammatory bowel disease (IBD) remains underexplored with limited guidance. While promising clinical trials are currently underway, there is a need for further evidence-based recommendations. As such, we summarize the current evidence on various diets used in the treatment of IBD and also explore the potential applications of dietary data from related immune-mediated inflammatory diseases (IMIDs), such as rheumatoid arthritis and psoriasis, to provide additional information to inform IBD providers. To date, there have been multiple diets investigated as adjunctive therapy in IBD, but many associated studies are small, non-randomized, and not controlled. Mediterranean, vegetarian/vegan, and reduced-calorie/fasting diets have been studied and have shown some positive results in other IMIDs, which may suggest potential applicability to those with IBD, but larger, well-designed clinical trials are needed for further guidance. Gluten-free and low fermentable oligosaccharides, disaccharides, monosaccharides, and polyols fermentable oligosaccharides, disaccharides, monosaccharides, and polyols (FODMAP)diets do not appear to have an impact on IBD disease activity, but low FODMAP may potentially be helpful for those with concurrent functional gastrointestinal symptoms. Specific carbohydrate diets have been mainly assessed in children but show some potential in small adult studies.
[Nutrition in the etiopathogenesis of chronic inflammatory bowel diseases]. [2016]It is currently held that the pathogenesis of inflammatory bowel disease (IBD) involves a complex interaction of host responses, some immunologic and genetically determined, and external influences including microbial and dietary factors. Nutritional surveys and studies testing stepwise exclusion dietary compounds have suggested that dietary factors might be linked to the occurrence of IBD. Food allergy was suggested early as a possible trigger for the inflammatory response; however, no firm evidence has been gathered over the years to substantiate this possibility. The possibility that patients with Crohn's disease may have an unusual premorbid pattern of dietary intake has also been examined since the early seventies. Several groups of investigators report a high intake of refined sugars (i.e. sucrose), recycled cooking oil, a more frequent consumption of fast foods in patients with Crohn's disease and ulcerative colitis respectively. However, a critical comparison of incidence and prevalence studies published from 1976 until 1994 clearly showed no pre-existing nutritional abnormality that has been identified consistently in patients who develop inflammatory bowel disease.
An anti-inflammatory diet as treatment for inflammatory bowel disease: a case series report. [2022]The Anti-Inflammatory Diet (IBD-AID) is a nutritional regimen for inflammatory bowel disease (IBD) that restricts the intake of certain carbohydrates, includes the ingestion of pre- and probiotic foods, and modifies dietary fatty acids to demonstrate the potential of an adjunct dietary therapy for the treatment of IBD.