Alkylating agents
Surgery, Radiation & Chemotherapy for Early-Stage Hodgkin's Lymphoma
This trial is studying how well surgery, radiation therapy, and/or combination chemotherapy work in treating young patients with newly diagnosed stage I or stage II lymphocyte predominant Hodgkin disease.
Histone Deacetylase Inhibitor
Vorinostat + Rituximab + Chemotherapy for Diffuse Large B-Cell Lymphoma
This trial is studying the side effects and best dose of vorinostat when given with rituximab and chemotherapy to treat patients with newly diagnosed stage II-IV diffuse large B-cell lymphoma.
Stem Cell Transplantation
Stem Cell Transplant for Non-Hodgkin's Lymphoma
This trial is testing a new two-step approach to treating high-risk non-Hodgkin's lymphoma. First, the patient's own blood cells are transplanted. Then, a transplant from another individual is performed. The goal is to improve the chances for long-term control of lymphoma.
Popular Filters
Trials for Mantle Cell Lymphoma Patients
Alkylating agents
Cord Blood Transplant + Chemo/Radiation for Leukemia and Lymphoma
This trial is testing whether giving an umbilical cord blood transplant together with chemotherapy and radiation therapy works better than just giving an umbilical cord blood transplant for treating patients with hematologic disease.
Chemotherapy
New Cancer Treatment for Non-Hodgkin's Lymphoma
This trial is testing a new cancer treatment for children with B-cell NHL. The new treatment is based on the successful LMB-96 regimen. The trial features prospective biologic and late effect studies.
Trials for Follicular Lymphoma Patients
Alkylating agents
Cord Blood Transplant + Chemo/Radiation for Leukemia and Lymphoma
This trial is testing whether giving an umbilical cord blood transplant together with chemotherapy and radiation therapy works better than just giving an umbilical cord blood transplant for treating patients with hematologic disease.
Trials for CD20 Positive Patients
Chemotherapy
New Cancer Treatment for Non-Hodgkin's Lymphoma
This trial is testing a new cancer treatment for children with B-cell NHL. The new treatment is based on the successful LMB-96 regimen. The trial features prospective biologic and late effect studies.
Kinase Inhibitor
Ibrutinib + Rituximab for Mantle Cell Lymphoma
This trial is testing ibrutinib and rituximab as a treatment for mantle cell lymphoma. Ibrutinib may stop the growth of cancer cells by blocking enzymes needed for cell growth. Monoclonal antibodies, such as rituximab, may find cancer cells and help kill them.
Monoclonal Antibodies
Rituximab + Chemotherapy +/- Lenalidomide for Lymphoma
This trial is testing rituximab and combination chemotherapy with or without lenalidomide to treat patients with newly diagnosed stage II-IV diffuse large B cell lymphoma to see if it is more effective with or without lenalidomide.
Immunomodulatory Agent
Triple Therapy for CLL/SLL
This trial is studying the side effects and best dose of lenalidomide when given with ibrutinib and rituximab to treat patients with CLL or SLL that has come back, is refractory, has spread, or cannot be removed by surgery.
Phase 3 Trials
Chemotherapy
New Cancer Treatment for Non-Hodgkin's Lymphoma
This trial is testing a new cancer treatment for children with B-cell NHL. The new treatment is based on the successful LMB-96 regimen. The trial features prospective biologic and late effect studies.
Kinase Inhibitor
Long-term Ibrutinib for Lymphoma
This trial aims to provide ongoing access to ibrutinib for patients who have benefited from it in previous studies. Ibrutinib is an oral medication that blocks a protein involved in cancer growth, helping to slow or stop the disease. The study will monitor safety and effectiveness over time. Ibrutinib has been studied extensively and is used to treat various B cell malignancies, including chronic lymphocytic leukemia and mantle cell lymphoma.
Trials With No Placebo
Monoclonal Antibodies
SGN-35T for Lymphoma
This trial is testing a new drug in adults with certain types of lymphoma that haven't responded to other treatments. The drug works by targeting a protein on cancer cells and delivering a substance that kills them. This drug has shown high selectivity against specific cancer cells and has been approved for treating lymphoma patients.
Alkylating agents
Cord Blood Transplant + Chemo/Radiation for Leukemia and Lymphoma
This trial is testing whether giving an umbilical cord blood transplant together with chemotherapy and radiation therapy works better than just giving an umbilical cord blood transplant for treating patients with hematologic disease.
View More Related Trials
Frequently Asked Questions
Introduction to ctcl
What are the top hospitals conducting ctcl research?
When it comes to clinical trials for Cutaneous T-Cell Lymphoma (CTCL), several hospitals are leading the way in research and treatment options. In Saint Louis, Washington University School of Medicine is at the forefront with eight active CTCL trials and a total of ten completed trials. Since recording their first CTCL trial in 2005, they have been dedicated to advancing our understanding and treatment of this rare type of lymphoma. Another notable institution making strides in CTCL research is the City of Hope Comprehensive Cancer Center located in Duarte. With seven ongoing clinical trials and six previously conducted studies since their debut trial in 2006, they are committed to finding innovative solutions for patients with this challenging condition.
In Honolulu, Kapiolani Medical Center for Women and Children is actively involved in conducting six CTCL trials. Although they do not have any recorded past trials specifically focused on this disease yet, their contribution towards current research efforts showcases their commitment to improving outcomes for those affected by CTCL. Johns Hopkins University/Sidney Kimmel Cancer Center, situated in Baltimore, is also playing a significant role with six active clinical trials focusing on CTCL as well as three previously conducted studies dating back to their initial trial in 2005.
Lastly, City of Hope Medical Center deserves recognition not only for its location but also its contributions to fighting against CTCL. They currently have six active clinical trials underway alongside an impressive record of eleven completed studies since embarking on their inaugural trial back in 1997.
These hospitals exemplify the dedication and collaborative efforts required to make advancements in addressing the complexities surrounding Cutaneous T-Cell Lymphoma. Through these ongoing clinical trials and accumulated knowledge gained from previous studies, researchers aim to improve treatment options while offering hope and support to individuals impacted by this rare form of cancer
Which are the best cities for ctcl clinical trials?
When it comes to CTCL (cutaneous T-cell lymphoma) clinical trials, several cities have emerged as prime locations for research. Honolulu, Hawaii leads the way with 40 ongoing trials, focusing on treatments like Vorinostat and rituximab, as well as laboratory biomarker analysis. Following closely behind are Chicago, Illinois with 32 active studies exploring various treatment options such as Daunorubicin Hydrochloride and Ofatumumab, and Boston, Massachusetts with 28 ongoing trials investigating treatments like Nivolumab and Rituximab. Houston, Texas and Los Angeles, California also stand out with 28 active trials each studying different approaches including Radiation Therapy and CD19CAR-28-zeta T cells. These cities provide valuable opportunities for individuals seeking participation in cutting-edge CTCL clinical trials that could potentially lead to improved treatment outcomes.
Which are the top treatments for ctcl being explored in clinical trials?
Cutaneous T-cell lymphoma (CTCL) research is advancing with several promising treatments being explored in clinical trials. Leading the pack is rituximab, a drug currently undergoing six active trials for CTCL. Since its listing in 2011, it has been involved in two all-time clinical trials dedicated to this condition. Another contender is lenalidomide, which is currently being tested in three ongoing CTCL trials and has participated in seven all-time studies since its introduction in 2008. Additionally, a pharmacological study focusing on CTCL has also shown promise with three active trials and seven all-time studies starting from 2008. These innovative approaches bring hope for improved outcomes among individuals battling CTCL.
What are the most recent clinical trials for ctcl?
The field of cutaneous T-cell lymphoma (CTCL) is witnessing promising advancements through recent clinical trials. One notable trial involves the use of MT-101, which has progressed to both Phase 1 and Phase 2 stages. Another study focuses on IPH4102 and its potential benefits for CTCL patients in Phase 2 development since May 2019. Furthermore, researchers are exploring a unique approach utilizing an autologous lymphoma immunoglobulin-derived scFv-chemokine DNA vaccine during the initial phase of testing from February 2015 onwards. These endeavors mark important milestones in finding improved treatments for CTCL patients and offer hope for their future well-being.
What ctcl clinical trials were recently completed?
Recently completed clinical trials for cutaneous T-cell lymphoma (CTCL) have yielded important findings in the field. The Ludwig Institute for Cancer Research concluded a trial investigating Tremelimumab in December 2016, shedding light on its potential therapeutic benefits. Additionally, Stanford University wrapped up a trial examining anti-thymocyte globulin in May 2009. Although these trials were conducted several years ago, their outcomes continue to contribute valuable insights into the treatment of CTCL and guide future research efforts.