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Cipro vs Keflex
Introduction
For patients with bacterial infections, different types of antibiotics can help in eliminating bacteria and managing symptoms. Cipro (Ciprofloxacin) and Keflex (Cephalexin) are two such drugs that are often prescribed for such conditions. Both target bacterium but work differently to eradicate the infection.
Cipro is a type of antibiotic known as a fluoroquinolone, which works by inhibiting DNA gyrase, an enzyme crucial for bacterial DNA replication. This action prevents bacteria from multiplying and leads to their death.
On the other hand, Keflex is classified as a cephalosporin antibiotic. It disrupts the synthesis of the bacterial cell wall leading to exposure of the plasma membrane which eventually results in cell lysis and death.
It's important to note that while both drugs serve similar purposes – battling bacterial infections – they each have different side effect profiles, dosages, drug interactions and specific uses based on the strain of bacterium being targeted.
Cipro vs Keflex Side By Side
| Attribute | Cipro | Keflex |
|---|---|---|
| Brand Name | Cipro | Keflex |
| Contraindications | Cannot be taken with tizanidine. Caution in patients with kidney disease or gastrointestinal diseases like colitis. Consultation required for pregnant women or nursing mothers. | Cannot be taken with tizanidine. Caution in patients with kidney disease or gastrointestinal diseases. Consultation required for pregnant women or nursing mothers. |
| Cost | For brand name: around $220 for 20 tablets of 500 mg. For generic: as low as $.02 - $.10 per pill. | For brand name: around $210 for 28 capsules of 500 mg. For generic: as low as $.01 - .07 per pill. |
| Generic Name | Ciprofloxacin | Cephalexin |
| Most Serious Side Effect | Tendon rupture, effects on heart rhythm, signs of nervous system reaction. | Severe skin reactions, trouble breathing or swallowing due to allergic reaction, seizures. |
| Severe Drug Interactions | Medication containing tizanidine. | May interfere with certain lab tests, including urine glucose tests. |
| Typical Dose | 250-750 mg every 12 hours. For UTIs, 250-500 mg every 12 hours is usually sufficient. | 250 mg to 500 mg, taken orally every 6 hours. Dose may increase up to 1-4 g daily, depending on the infection. |
What is Cipro?
Ciprofloxacin (the generic name for Cipro) is a member of the fluoroquinolone class of antibiotics, known for its potent antibacterial effects. It was first approved by the FDA in 1987. Cipro works by interfering with bacterial enzymes, effectively inhibiting their growth and multiplication in the body. It is prescribed for treating various types of bacterial infections including urinary tract infections, respiratory tract infections, skin infections and others. Unlike cephalosporin antibiotics like cephalexin (Keflex), which are primarily used against Gram-positive bacteria, Cipro has broad-spectrum activity against both Gram-negative and Gram-positive bacteria. This makes it more versatile but also increases the risk of developing resistance if used indiscriminately. Also noteworthy is that while Keflex may cause fewer side effects such as gastrointestinal issues compared to Cipro; however, individuals allergic to penicillin have a higher chance of being allergic to Keflex as well.
What conditions is Cipro approved to treat?
Cipro (ciprofloxacin) is approved for the treatment of various bacterial infections, including:
- Urinary tract infections
- Respiratory tract infections
- Skin and soft tissue infections
- Bone and joint infections
- Infectious diarrhea caused by certain bacteria.
Keflex (cephalexin), on the other hand, is used to treat a slightly narrower range of bacterial diseases:
- Respiratory tract infection
- Otitis media (middle ear infection)
- Skin and soft tissue infections
How does Cipro help with these illnesses?
Ciprofloxacin, often known as Cipro, is an antibiotic from the fluoroquinolone class that fights bacteria in the body. It does this by inhibiting DNA-gyrase and topoisomerase IV, two enzymes necessary for bacteria to replicate and repair their DNA. This leads to bacterial cell death and clears up the infection.
On the other hand, Keflex belongs to a group of antibiotics called cephalosporins which function differently than fluoroquinolones. They inhibit bacterial cell wall synthesis by binding to specific proteins in the bacterial cell membrane. The compromised structure of this protective layer results in instability causing lysis or destruction of bacteria.
Both are potent antibiotics but they differ in their mechanism of action as well as their spectrum of activity against different types of bacteria. Therefore, whether Cipro or Keflex is chosen will depend on the type and location of infection along with other patient factors such as allergies or interactions with other medications being taken.
What is Keflex?
Keflex is a brand name for cephalexin, which is a first-generation cephalosporin antibiotic. It works by inhibiting bacterial cell wall synthesis, thus leading to the death of the bacteria. Keflex was first approved by the FDA in 1971 and it's commonly used to treat various types of infections caused by susceptible gram-positive bacteria such as cellulitis, otitis media (ear infection), pharyngitis (throat infection), urinary tract infections among others.
Unlike Ciprofloxacin (Cipro) which is a broad-spectrum fluoroquinolone antibiotic effective against both gram-negative and gram-positive bacteria, Keflex lacks action against most strains of enterobacteriaceae, pseudomonas aeruginosa and methicillin-resistant staphylococcus aureus (MRSA). This means that its side-effect profile may be different compared to that of Cipro. For instance, it does not tend to cause tendon rupture or heart rhythm disturbance - two potential but rare side effects associated with Cipro use.
The effectiveness of Keflex can be beneficial for treating certain common infections especially when they are known or suspected to be caused by Gram positive organisms sensitive to this medication
What conditions is Keflex approved to treat?
Keflex, a first-generation cephalosporin, is approved for the treatment of various bacterial infections such as:
- Skin and soft tissue infections
- Respiratory tract infections
- Urinary tract infections This drug is particularly useful when treating conditions caused by Gram-positive bacteria like Staphylococcus and Streptococcus species.
How does Keflex help with these illnesses?
Keflex is a cephalosporin antibiotic that interferes with bacterial cell wall synthesis, causing the bacteria to rupture and die. It plays an essential role in fighting off many types of infections caused by susceptible bacteria including skin, ear, bone, and urinary tract infections. Like ciprofloxacin (Cipro), Keflex serves as a powerful weapon against bacterial invasions but it primarily targets gram-positive bacteria which makes it particularly effective in conditions like Staphylococcal or Streptococcal infections. Moreover, compared to Cipro which may have more severe side effects such as tendonitis and nerve damage, Keflex tends to be better tolerated by most patients making it a preferred choice for those who cannot tolerate fluoroquinolones like Cipro.
How effective are both Cipro and Keflex?
Both ciprofloxacin (Cipro) and cephalexin (Keflex) are well-established antibiotics, having been approved by the FDA in 1987 and 1971 respectively. They act on different types of bacteria hence may be prescribed under different circumstances based on the type of infection. Cipro is a broad-spectrum antibiotic that belongs to the quinolone group, whereas Keflex is a first-generation cephalosporin.
In terms of effectiveness, both have shown efficacy in treating bacterial infections; however, their use depends largely on the type of bacteria responsible for an infection. For example, Cipro would typically be more effective against gram-negative organisms such as E.coli or Pseudomonas aeruginosa while Keflex tends to work better with gram-positive infections like Staphylococcus aureus. It's also worth noting that due to its broader spectrum action, use of Cipro should typically be reserved for more severe or resistant cases because indiscriminate usage can contribute to antibiotic resistance.
A review from 2004 showed that both drugs were highly effective in treating skin and soft tissue infections with similar safety profiles. However, it was noted that patients taking Cipro had slightly higher rates of gastrointestinal side effects.
A meta-analysis conducted in 2016 indicated that although both medications are generally safe and well-tolerated when used appropriately, there are certain situations where one may be preferred over another depending upon patient-specific factors including allergies or intolerances and potential drug-drug interactions.
It’s important to remember every individual might respond differently to these antibiotics; therefore considering patient history and specific needs is vital before prescribing either medication.
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At what dose is Cipro typically prescribed?
Oral dosages of Cipro range from 250-750 mg every 12 hours, but research suggests that for common conditions like urinary tract infections, a dose of 250-500 mg every 12 hours is usually sufficient. Children and adolescents may be started on lower doses based on body weight, typically around 10-20mg/kg every 12 hours. In either population, the dosage can be increased if no response is seen after few days. The maximum dosage should not exceed 1500 mg/day in adults or specific calculated dose in children and adolescents based on their weight.
At what dose is Keflex typically prescribed?
Keflex treatment is typically initiated at a dosage of 250 mg to 500 mg, taken orally every 6 hours. The dose may then be increased up to 1-4 g daily, divided into two or four doses, depending on the type and severity of the infection. For severe or life-threatening infections like endocarditis or pneumonia, a maximum dose of up to 4 g/day in equally spaced doses could be considered if there's no response after an initial period of treatment. As always, it's crucial that patients follow their healthcare provider's instructions regarding dosage adjustments.
What are the most common side effects for Cipro?
Common side effects of Cipro (Ciprofloxacin) and Keflex (Cephalexin) may vary. For Cipro, these could include:
- Nausea
- Diarrhea
- Vomiting
- Stomach upset or abdominal pain
- Rash
- Itching or unusual skin sensations
- Restlessness or nervousness
- Dizziness
For Keflex, some common side effects might be:
- Diarrhea
- Nausea
- Vomiting
- Indigestion
- Abdominal cramps/pain
- Dizziness
- Fatigue
- Headache
- Agitation and confusion in rare cases
Remember to contact a healthcare provider if any of the symptoms persist or worsen.
Are there any potential serious side effects for Cipro?
While Cipro and Keflex are effective antibiotics, they can potentially cause serious side effects. These may include:
- Signs of a nervous system reaction such as seizures or convulsions, tremors, hallucinations or nightmares
- Allergic reactions like skin rash, itching or hives; swelling of the face, lips or tongue
- Effects on heart rhythm: feeling faint or lightheadedness; fast, slow or irregular heartbeat
- Symptoms indicating low blood sugar - headache, hunger, sweating, irritability, dizziness
- Severe diarrhea (bloody or watery) with stomach cramps and fever which could be a sign of a new infection
- Tendon rupture: sudden pain in the calf/ankle/foot/toe; difficulty moving around
If you experience any severe symptoms while taking either Ciprofloxacin (Cipro) or Cephalexin (Keflex), it is crucial to seek immediate medical attention. Always remember that your doctor has prescribed these medications because they believe the benefits outweigh potential risks. However if you notice unusual changes in your body's response after starting treatment with either drug it's important to reach out to your healthcare provider promptly.
What are the most common side effects for Keflex?
The common side effects associated with Keflex (Cephalexin) include:
- Mild stomach upset, abdominal pain
- Diarrhea
- Joint or muscle pain
- Headache
- Dizziness
- Fatigue and a feeling of general malaise.
It's crucial to note that while these symptoms are usually mild, if they persist or worsen over time, you should consult your healthcare provider immediately. Also, although rare, some patients may experience severe intestinal conditions due to a type of resistant bacteria. Symptoms can occur weeks after treatment has stopped and might include: persistent diarrhea, abdominal or stomach pain/cramping along with blood/mucus in stool. If any of these severe effects occur seek medical attention right away.
Are there any potential serious side effects for Keflex?
While Keflex is generally well-tolerated, it can cause serious side effects in rare cases. These symptoms may include:
- Severe skin reactions such as hives, itching, rashes with blistering and peeling
- Trouble breathing or swallowing due to allergic reaction
- Swelling of your face, lips, tongue or throat
- Jaundice (yellowing of the eyes or skin)
- Unusual bleeding or bruising; blood in urine/stool
- Hallucinations and confusion -Seizures
If any of these symptoms occur while taking Keflex, immediate medical attention should be sought. It's crucial to note that this medication might interfere with certain lab tests (including some types of urine glucose tests), possibly causing false test results so always inform all your healthcare professionals who treat you that you are using Keflex.
Contraindications for Cipro and Keflex?
Both Cipro (ciprofloxacin) and Keflex (cephalexin), along with most other antibiotic medications, can cause side effects that range from mild to severe. If you notice symptoms such as hives, difficulty breathing or swallowing, swelling of lips, face or tongue, rapid heartbeat, yellowing of the skin or eyes (jaundice), dark urine, unusual bleeding or bruising after taking these antibiotics please seek immediate medical attention.
Neither Cipro nor Keflex can be taken if you are consuming medication containing tizanidine. Always inform your physician about any medications you are taking; tizanidine needs a washout period to prevent dangerous interactions with both ciprofloxacin and cephalexin.
For those suffering from kidney disease or gastrointestinal diseases like colitis should use these drugs cautiously. Also remember pregnant women or nursing mothers must consult their doctor before starting these antibiotics.
How much do Cipro and Keflex cost?
For the brand name versions of these drugs:
- The price for 20 tablets of Cipro (500 mg) averages around $220, which works out to about $11/day, depending on your dose.
- The price of 28 capsules of Keflex (500 mg) averages is about $210, working out to approximately $7.50/day.
Thus, if you are in the higher dosage range for Cipro (i.e., 1000 mg per day or higher), then brand-name Keflex may be less expensive on a per-day treatment basis. Please note that cost should not be a primary consideration in determining which antibiotic is right for you.
For the generic versions:
- Ciprofloxacin (generic version of Cipro) can be found at prices as low as $.02 - $.10 per pill ($0.2 - $1 daily).
- Similarly, cephalexin (generic version of Keflex), is available at costs from $.01 - .07 per pill ($.05-.70 daily).
These costs depend heavily on whether insurance covers part or all of the prescription and where it's purchased from.
Popularity of Cipro and Keflex
Ciprofloxacin, in generic form as well as brand names such as Cipro, was estimated to have been prescribed to about 16 million people in the US in 2020. Ciprofloxacin accounted for just over 8% of antibiotic prescriptions in the US. However, it appears to be the most-common “fluoroquinolone” antibiotic (not classified under other broad classes of antibiotics). The prevalence of ciprofloxacin has been generally steady since 2013.
Cephalexin, including brand versions such as Keflex, was prescribed to approximately 20 million people in the USA during 2020. In the US alone, cephalexin accounts for nearly a quarter of all cephalosporin class prescription drugs and around 11% of overall antibiotic prescriptions. The utilization rate for cephalexin has remained fairly constant over the last decade.
Conclusion
Both Cipro (ciprofloxacin) and Keflex (cephalexin) are antibiotics with a long history of use in treating bacterial infections, supported by numerous clinical studies indicating their effectiveness over placebo treatments. Due to their different mechanisms of action, they are typically prescribed for different types of infections; ciprofloxacin is a broad-spectrum antibiotic that inhibits the replication of bacteria by blocking two enzymes necessary for the bacteria to multiply while cephalexin works by interfering with the formation of the bacterium's cell wall.
Cipro is often used as a treatment option for urinary tract infections, respiratory tract infections, and skin infections, among others. On the other hand, Keflex is commonly used to treat skin and soft tissue infections and upper respiratory tract infections. Both drugs have generic versions available which can offer cost savings especially for patients who must pay out-of-pocket.
The side-effect profiles vary between these two antibiotics: both can cause gastrointestinal disturbances but Cipro may potentially lead to more serious side effects such as tendon rupture or damage to nerves. It's also important to note that Cipro has been associated with an increased risk of Clostridium difficile infection compared to other antibiotics.
For both drugs, it’s crucial that patients complete their full course even if symptoms improve before finish taking all medication as directed by their doctor – not doing so could allow bacteria resistant strains develop.
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Refrences
- Peltola, H., Ukkonen, P., Saxén, H., & Staβ, H. (1998, April 1). Single-dose and Steady-state Pharmacokinetics of a New Oral Suspension of Ciprofloxacin in Children. Pediatrics. American Academy of Pediatrics (AAP).http://doi.org/10.1542/peds.101.4.658
- Giordano, P. A., Elston, D., Akinlade, B. K., Weber, K., Notario, G. F., Busman, T. A., … Nilius, A. M. (2006, October 30). Cefdinir vs. cephalexin for mild to moderate uncomplicated skin and skin structure infections in adolescents and adults. Current Medical Research and Opinion. Informa UK Limited.http://doi.org/10.1185/030079906x148355